2. Research on the rules of crystallization inhibition of cellulose polymers against supersaturated drugs by solubility test
Chinese Pharmaceutical Journal 2016;51(13):1137-1142
OBJECTIVE: To explore the characteristics of crystallization inhibition by cellulose polymers against supersaturated drugs. METHODS: The biopharmaceutics classification system(BCS) II class drug indometacin was selected as the model drug.Supersaturated amorphous drug solid was prepared and the solubility of indometacin was measured. The types, added amounts, ionic intensity and viscosity of cellulose polymers were employed as influential factors to assess the crystallization inhibition effect of polymers against indometacin. RESULTS: HPMC E15 displayed the strongest crystallization inhibition effect. The crystallization inhibition was enhanced by adding larger amount of polymers, decreasing the viscosity of polymers and increasing the ionic intensity. CONCLUSION: The study is helpful to clarify the profiles that cellulose polymers inhibit the crystallization of drugs in supersaturated states. This research may provide scientific guide for the practical application of cellulose polymers for drug crystallization.
3. Comparison of the properties of curcumin solid dispersions prepared by different technologies
Chinese Pharmaceutical Journal 2016;51(10):821-826
OBJECTIVE: To prepare curcumin solid dispersions by different preparation technologies and compare their properties. METHODS: Curcumin/poloxamer 407 solid dispersions were prepared by freeze-drying, co-precipitation and microwave/quench cooling methods, respectively. Internal properties of obtained solid dispersion were analyzed by SEM, DSC, XRD and FT-IR. The improvement effect on the insolubility of curcumin by making it into solid dispersions by different technologies was characterized by dissolution and solubility experiments. RESULTS: Curcumin was dispersed in solid dispersions in micro-crystal form. Compared with other technologies, microwave/quench cooling method could significantly improve the solubility and dissolution of insoluble curcumin. CONCLUSION: The study provides reference for choice of applicable production technology for solid dispersions of insoluble Chinese traditional medicine curcumin.
4.The toxic effect of methamidophos and acephate on intracellular free Ca2+ and cAMP concentration in rat brain tissue.
Dan CHEN ; Nian SHI ; Tao LI ; Bin WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(4):279-280
Animals
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Binding Sites
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drug effects
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Brain
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metabolism
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Calcium
;
metabolism
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Cerebral Cortex
;
metabolism
;
Cyclic AMP
;
metabolism
;
Hippocampus
;
metabolism
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Insecticides
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toxicity
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Male
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Organothiophosphorus Compounds
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toxicity
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Phosphoramides
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Rats
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Rats, Sprague-Dawley
6.Isolation and Identification of a Lipopeptide
Ying-Nian LV ; Shi-Zhong YANG ; Bo-Zhong MU ;
Microbiology 1992;0(01):-
A lipopeptide compound was isolated from the culture of Bacillus subtilis HSO121 by methods of acidic precipitation, solvent extract, fractional precipitation, adsorption and prepared thin-layer chromatography; and its molecular structure was determined by by ninhydrin assay and IR methods following the Amino analysis, MS-MS and ESI-MS. It shows that the isolated lipopeptide consists of two homologues with molecular mass 1,022D and 1,036D and bearing a cyclic structure with the amino acid sequence Leu-Leu-Asp-Val-Leu-Leu-Glu in the peptide chain, which indicates that the isolated lipopeptide falls into the analogs of surfactin.
7.The development of co-amorphous drug systems.
Jing YAO ; Nian-Qiu SHI ; Xing-Lin WANG
Acta Pharmaceutica Sinica 2013;48(5):648-654
Converting two poorly water-soluble crystalline drugs to co-amorphous drug systems by ball milling, quench-cooling, or cryo-milling method can improve stability of the drug, enhance dissolution rates, and reduce adverse reactions of the single drug. Co-amorphous system has been used to solve problems of co-administration of medicines. Formation and intermolecular interactions of co-amorphous drug systems may be verified by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), Raman spectroscopy (RS) and Fourier transform infrared spectroscopy (FT-IR). Stability of co-amorphous drug systems is influenced by their glass transition temperature (Tg) and intermolecular interactions. The theoretical Tg values and the interaction parameter x are calculated by Gordon-Taylor equation and the Flory-Huggins equation, respectively. Thus, co-amorphous drug systems are analyzed theoretically at molecular level. Co-amorphous drug systems provide a new sight for the co-administration of medicines.
Calorimetry, Differential Scanning
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Chemistry, Pharmaceutical
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methods
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Cimetidine
;
chemistry
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Drug Combinations
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Drug Compounding
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Drug Stability
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Glipizide
;
chemistry
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Indomethacin
;
chemistry
;
Naproxen
;
chemistry
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Ranitidine
;
chemistry
;
Simvastatin
;
chemistry
;
Solubility
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Spectroscopy, Fourier Transform Infrared
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Spectrum Analysis, Raman
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Technology, Pharmaceutical
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methods
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Temperature
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X-Ray Diffraction
8.Elongated needle with passive flexion of the hip and knee for 40 cases of acute lumbar sprain.
Ming NIU ; Ming-Xin XUE ; Shi-Nian ZHANG
Chinese Acupuncture & Moxibustion 2013;33(8):737-738
Adult
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Aged
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Female
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Hip
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physiopathology
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Humans
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Knee
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physiopathology
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Lumbosacral Region
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injuries
;
physiopathology
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Male
;
Middle Aged
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Range of Motion, Articular
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Sprains and Strains
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physiopathology
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therapy
;
Young Adult
9.Effect of oxymatrine on serum matrix metalloproteinase-2 and its inhibitor in patients with chronic hepatitis B and liver cirrhosis.
Jiang LIU ; Bai-nian SHI ; Jian-fang HE
Chinese Journal of Integrated Traditional and Western Medicine 2005;25(11):989-992
OBJECTIVETo observe the effect of oxymatrine on the level of serum matrix metalloproteinase-2 (MMP-2) and its inhibitor (TIMP-2) in patients with chronic hepatitis B (CHB) and post-hepatitis B liver cirrhosis (LC), as well as on liver fibrosis indexes as hyaluronic acid (HA), laminin (LN) and IV type collagen (IV C).
METHODSChanges of all the above-mentioned indexes in patients with CHB (n = 36) and LC (n = 36) before and after treatment were determined, and the relationship of MMP-2 and TIMP-2 with liver fibrosis indexes were analyzed.
RESULTSOxymatrine could decrease the levels of MMP-2, HA, LN and IV C in patients with severe or moderate CHB and LC of Child-pugh A, B and C grade, as compared with the data before treatment (P < 0.05). Serum level of MMP-2 and TIMP-2 was well correlated with the levels of liver cirrhosis indexes.
CONCLUSIONMMP-2 and TIMP-2 can be used as a reference for evaluating the degree of LC, and oxymatrine has a certain anti-LC effect.
Adolescent ; Adult ; Aged ; Alkaloids ; therapeutic use ; Collagen Type IV ; blood ; Female ; Hepatitis B, Chronic ; complications ; drug therapy ; enzymology ; Humans ; Hyaluronic Acid ; blood ; Laminin ; blood ; Liver Cirrhosis ; complications ; drug therapy ; enzymology ; Male ; Matrix Metalloproteinase 2 ; blood ; Middle Aged ; Quinolizines ; therapeutic use ; Sophora ; Tissue Inhibitor of Metalloproteinase-2 ; blood
10.Application of microwave irradiation technology to the field of pharmaceutics.
Xue-Bing ZHANG ; Nian-Qiu SHI ; Zhi-Qiang YANG ; Xing-Lin WANG
Acta Pharmaceutica Sinica 2014;49(3):303-309
Microwaves can be directly transformed into heat inside materials because of their ability of penetrating into any substance. The degree that materials are heated depends on their dielectric properties. Materials with high dielectric loss are more easily to reach a resonant state by microwaves field, then microwaves can be absorbed efficiently. Microwave irradiation technique with the unique heating mechanisms could induce drug-polymer interaction and change the properties of dissolution. Many benefits such as improving product quality, increasing energy efficiency and reducing times can be obtained by microwaves. This paper summarized characteristics of the microwave irradiation technique, new preparation techniques and formulation process in pharmaceutical industry by microwave irradiation technology. The microwave technology provides a new clue for heating and drying in the field of pharmaceutics.
Chemistry, Pharmaceutical
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methods
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Drug Discovery
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instrumentation
;
methods
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Microwaves
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Pharmaceutical Preparations
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administration & dosage
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chemistry
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Technology, Pharmaceutical
;
methods