As a distinct clinicopathological entity, mediastinal gray zone lymphoma cannot be classified by using differential diagnostic criteria. The cases represent a spectrum of tumors having characteristics of both primary mediastinal large B-cell lymphoma (PMBL) and classic Hodgkin lymphoma (cHL). In the 2008 WHO Classification, a novel category designated B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu) has been created to include these neoplasms. The main features of BCLu are clearly different from those of conventional mediastinal large B-cell lymphomas. Diagnosis of BCLu requires a multiparameter approach incorporating morphological, immunophenotypic, immunohistochemical and other features. These lymphomas generally have a more aggressive clinical course and poorer outcome. There is no consensus on the optimum treatment, while the recommended therapies for aggressive B-cell lymphomas might be effective options.

Objective To investigate the clinical efficacy and safety between laparoscopic and transabdomi -nal hysterectomy ,reduce the occurrence of complications measures .Methods On 154 cases of hysterectomy indica-tions were nonrandomly divided into two groups ,one group for the observation group of 79 cases of laparoscopic opera-tion,another group was control group of 75 patients with transabdominal operation;two groups had no significant differ-ence in age and disease .The clinical effect ,postoperative complications and safety between the two groups during and after operations were observed .Results The operation time of the laparoscopic group (72.0 ±13.2) min was signifi-cantly shorter than that of the control group (98.0 ±20.7)min (t=3.396,P=0.021);The bleeding quantity of the laparoscopic group(96.0 ±75.4)mL was significantly shorter than that of the control group (159.4 ±98.0)mL(t=9.680,P=0.014);The aerofluxus time of the laparoscopic group (17.2 ±4.2) h was significantly shorter than that of the control group(28.6 ±6.1)h(t=9.760,P=0.013).The average postoperative hospital stay time was significantly shorter in laparoscopic group(5.2 ±1.9)d than those in abdominal group(9.5 ±3.2)d (t=-5.025,P=0.018). The analgesic used in the laparoscopic group (3/89)was significantly shorter than that in the control group (48/78) (t=-8.820,P=0.000).Conclusion Laparoscopic hysterectomy is safe and effective .It is worth to promote in clinical,while improving the operation skills is the key to reduce the complications .

Twenty-three joints in 14 cases of chronic synovitis were treated with intra-articular injection of 32 p-chromic phosphate, including 19 knee joints, one elbow joint with rheumatoid arthritis and 3 knee joints with degenerative arthritis that was recractory to medical treatment. Results of 23 joints evaluated at end of one year were excellent in 43.5$, good in 30.5%, .fair in 13% and poor in 13%. There was a good correlation between the radiographic stage of the joints and the response to treatment. Patients in stage 1 and 2 were more likely to have good to excellent response. Cur study shows that radiation synovectomy is a simple, safe and effective treatment than other managements for chronic synovitis

Objective: To investigate the clinical value of continuous passive motion (CPM) and sodium hyaluronate (SH) in the patellar fracture patients postoperatively. Methods: Seventy - two cases of the patellar fracture were treated with SH and CPM machine postoperatively. Results: All of the patients experienced primary healing. The functions of the knee joint recovered well. All patients were followed up over six months,and none of them were found to have suffered from traumatic arthritis. Conclusion :The application of CPM and SH in the patellar fracture patients postoperatively has the satisfactory results of reducing pain,speeding up the healing of cartilage and improving the functions of knee joint. It is efficient to stop the process of traumatic arthritis following the patellar fracture.

Objective:To investigate the effect of tension-band thread cable internal fixation for the treatment of patellar fracture.Methods:81 cases with patellar fracture were treated by tension-band thread cable internal fixation.Results:Among the follow-up 64 cases,from 1 to 8 years,the rate of excellent and good results was 90.6%.Conclusion:Tension-band cotton thread cable was firm,safe,simple and practical.There is no need for the patients to have the second removal of materials of internal fixation.It is advisable to use it in clinical practice.

Objective:To verify whether hot PBS washing after the enzymatic reaction between tyramine and horseradish peroxidase can improve the sensitivity and specificity of catalyzed signal amplification (CSA). Methods: Using 7 different types of primary antibodies and 2 tumor microarray system, we carried out EnVision, LSAB, Standard CSA, and modified CSA staining and compared their sensitivities and specificities. Results: The modified CSA method was the most sensitive one among the 4 methods, followed by standard CSA, EnVision, and LsAB method. The sensitivity of modified CSA method was 2-3 times higher than that of standard CSA. The 4 methods had similar background staining and had exact localization of cells. Conclusion: The modified CSA is more stable and sensitive than traditional CSA staining method.

AIM: To compare the efficacy and safety of oxiracetam and donepezil in treating Alzheimer disease with mild and moderate MMSE scores.METHODS: 68 patients were randomly divided into oxiracetam group(p.o.,n=34) and donepezil group(p.o.,n=34).The MMSE and Blessed-Roth measuring scales were used to evaluate the curative effects before treatment and three months after treatment.RESULTS: There were significant differences between the indexes expect for activities of daily living before and after treatment in two groups(P0.05).CONCLUSION: The curative effect and safety of oxiracetam and donepezil in treating mild and moderate Alzheimer disease are similar.

It didn't spread extensively whenInner Canon of Huangdi(Huangdi Nei Jing) was published.But the emperor in Song Dynasty attached importance to medicine and commanded the publishing bureau of correcting medical books to collate and publishPlain Questions(Su Wen).It was regarded as the teaching material of Imperial physician bureau.Inner Canon of Huangdi(Huangdi Nei Jing) was published in a large amount after the progress of printing technology.It impelled the book to be quite popular and spreading.The people studying on it increased day by day.It had a far-reaching impact on the development of medicine in later ages.

Aim To study the preventive and therapeutic effects of total flavonoids of Litsea Coreana level on nonalcoholic steatohepatitis in rats.Methods 48 SD rats were randomized into control,model,NA,TFLC(50,100,200 mg?kg~(-1))groups(n=8).The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion(10 ml?kg~(-1));At the same time,the control and model groups were fed with CMC-Na,the other groups were fed with relative medicine.The stool TG,TC,the serum TG,TC,ALT,AST,MDA,SOD and hepatic TG,TC,MDA,SOD were detected dynamically.Results The model group developed NASH after 3 weeks.NA and TFLC(100,200 mg?kg~(-1))significantly reduced TG of the serum and liver tissue,and ameliorated hepatocellular macrovesicular steatosis.TFLC(200 mg?kg~(-1))markedly inhibited increased MDA in serum and liver tissue,and also elevated SOD in liver tissue.Conclusions TFLC markedly reduced the TG level of serum and liver tissue.Liver histopathological examination showed TFLC ameliorated hepatocellular macrovesicular steatosis.The protective and therapeutic effects of TFLC on NASH may be associated with inhibitory effect of fat absorption and lipid peroxidation.

Objective:To investigate the effect of cable pin internalfixation for treatment of patellar fracture.Methods:12 cases with patellar fracture were treated by cable pin internalfixation.Results:The post-operative function in 12 cases was evaluated according to Lu Yu-pu score,follow-up averaged 10 months,and the results were :excellent in 9 cases(75%);good in 2 cases(16.7%);fair in 1 cases(8.3%);poor in 0 case.The excellent rate was 91.7%.Conclusion:Patellar fracture treated with cable pin has the advantages of simple manipulation,firm fixation,faster and guaranteed fracture heeling and good function of knee.The method meets the demands of biomechanics and the clinical result of this group is quite satisfactory.It is advisable to use it in clinical practice.