It didn't spread extensively whenInner Canon of Huangdi(Huangdi Nei Jing) was published.But the emperor in Song Dynasty attached importance to medicine and commanded the publishing bureau of correcting medical books to collate and publishPlain Questions(Su Wen).It was regarded as the teaching material of Imperial physician bureau.Inner Canon of Huangdi(Huangdi Nei Jing) was published in a large amount after the progress of printing technology.It impelled the book to be quite popular and spreading.The people studying on it increased day by day.It had a far-reaching impact on the development of medicine in later ages.

Aim To study the preventive and therapeutic effects of total flavonoids of Litsea Coreana level on nonalcoholic steatohepatitis in rats.Methods 48 SD rats were randomized into control,model,NA,TFLC(50,100,200 mg?kg~(-1))groups(n=8).The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion(10 ml?kg~(-1));At the same time,the control and model groups were fed with CMC-Na,the other groups were fed with relative medicine.The stool TG,TC,the serum TG,TC,ALT,AST,MDA,SOD and hepatic TG,TC,MDA,SOD were detected dynamically.Results The model group developed NASH after 3 weeks.NA and TFLC(100,200 mg?kg~(-1))significantly reduced TG of the serum and liver tissue,and ameliorated hepatocellular macrovesicular steatosis.TFLC(200 mg?kg~(-1))markedly inhibited increased MDA in serum and liver tissue,and also elevated SOD in liver tissue.Conclusions TFLC markedly reduced the TG level of serum and liver tissue.Liver histopathological examination showed TFLC ameliorated hepatocellular macrovesicular steatosis.The protective and therapeutic effects of TFLC on NASH may be associated with inhibitory effect of fat absorption and lipid peroxidation.

Effect of Na_2seo_3 on passive Heymann Nepharitis in rats was studied.The resuIts confirmedthat AIb,BUN,Chol and urine protein in experiment groups reduced than in control group,andthere were more slight pathologic change in ante—riority compared with posteriority.Abovephenomena associated with enhance of insistent oxydation by Se.It is Cnsidered that perhaps toadminister properly Se to the patient with immune complex diseases and immune complex—re-lated diseases is effectice

In order to investigate the role of ?-endorphin in the regulation of immune function,we ob-served in vitro and in vivo effects of ?-endorphinon on mitogen--induced spleen lymphocyte pro-liferation,interleukin—1 and interleukin—2 production,It was found that ?-endorphin at 10~(-8)-10~(-14)mol/L could enhance Con A induced proliferation and interleukin-2 production of spleniclymphocyte in vitro.B—endprphin couled also increase LPS induced interleukin—1 productionby peritoneal macropages.The augmentative effect of ?-endorphin on lymphocyte proliferationand interleukin—2 production was abrogate by naloxone.Intravenous injection of ?—endorphinalso increased the lymphoproliferation,interleukin—1 and interleukin—2 production.Our resultsindicated that ?-endorphin enhanced immune function of rats and this action of ?-endorphin maybemediated by opioid receptor.

Objective:To investigate the effect of cable pin internalfixation for treatment of patellar fracture.Methods:12 cases with patellar fracture were treated by cable pin internalfixation.Results:The post-operative function in 12 cases was evaluated according to Lu Yu-pu score,follow-up averaged 10 months,and the results were :excellent in 9 cases(75%);good in 2 cases(16.7%);fair in 1 cases(8.3%);poor in 0 case.The excellent rate was 91.7%.Conclusion:Patellar fracture treated with cable pin has the advantages of simple manipulation,firm fixation,faster and guaranteed fracture heeling and good function of knee.The method meets the demands of biomechanics and the clinical result of this group is quite satisfactory.It is advisable to use it in clinical practice.

Objective:To investigate the effect of tension-band thread cable internal fixation for the treatment of patellar fracture.Methods:81 cases with patellar fracture were treated by tension-band thread cable internal fixation.Results:Among the follow-up 64 cases,from 1 to 8 years,the rate of excellent and good results was 90.6%.Conclusion:Tension-band cotton thread cable was firm,safe,simple and practical.There is no need for the patients to have the second removal of materials of internal fixation.It is advisable to use it in clinical practice.

Objective To explore the effect of naphthalene acetic acid(NAA) on animal cells. Methods K562 cells were treated in vitro with different doses of NAA (0, 50 and 100?mol/L). The cell proliferation, cell cycle, cell division index and apoptosis was observed by means of MTT, cell enumeration, and flow cytometry. The sister chromatid exchange (SCE) and micronucleus were tested. Results The proliferation of K562 cell was inhibited by NAA compared with that of the controls; the cell cycle was arrested at G1, and the cell division index reduced; apoptosis cells increased lightly in NAA experiments; the frequency of SCE and micronuclear formation were increased by NAA treatment. Conclusion NAA has antiproliferative activities on K562 cell.

Objective To investigate the changes and clinical significance of hemorrheology and platelet parameters examination in patients with hypertension. Methods Hemorrheology and platelet parameters were detected in 78 patients with hypertension and in 72 healthy subjects as control group. Then difference were compared. Results The hemorrheology and platelet parameters in he patients with hypertension at stage Ⅰ were no different in comparison with the control group(all P＞0.05) ,which at stage Ⅱ and Ⅲ were significantly different in comparison with stage Ⅰ and the control group ( all P ＜ 0. 05). and at stage Ⅲ were significantly different in comparison with stage Ⅱ(all P＜0.05). Conclusion The changes ofhemorheology and platelet parameters were closely related with hypertension,which were helpful to the clinical diagnosis of hypertension and had important significance to the therapy, monitor and prognosis of hypertension.

Bionic cultivation of Chinese medicinal materials is an intensive Chinese herbal medicine production mode, applying engineering approach in reappearing ecological relationship between medical plants and external environment, adopting modern agricultural production technique, and absorbing the essence of traditional agriculture according to the growth habits of medicinal plants and their requirements on ecological environment. It has obvious economic benefits, ecological benefits and social benefits, adopts the bionic cultivation of authentic Chinese herbal medicine, which has great significance to protecting the ecological environment, improving the quality of cultivation of medicinal materials, meeting the demand of social medicine, and is also the most effective way to ensure the sustainable development of TCM resources.

Background and purpose:The extent of lymph node dissection for the stageⅢ lower rectal cancer is still a subject of debate. Some Japanese researchers recommend improved lateral lymph node dissection for stageⅢ lower rectal cancers while American scholars claim that total mesorectal excision is sufficient. This study aimed to explore the clinical significance of improved lateral lymph node dissection for stageⅢ lower rectal cancer in patients treated with radical resection.Methods:Sixty-six patients with stageⅢ lower rectal cancer were enrolled. Among these patients, 31 had been treated with radical resection combined with improved lateral lymph node dissection, whereas the others received radical resection without improved lateral lymph node dissection.Results:In the group of improved lateral lymph node dissection, five patients had positive lateral node including four poorly differentiated adenocarcinoma and one mucinous cell carcinoma. Compared with the group without improved lateral lymph node dissection, the group of improved lateral lymph node dissection showed significant difference in sexual disturbance, dysuresia and operation duration (P<0.05), but not in the presence of anastomotic fistula and blood loss during operation (P>0.05). Furthermore, patients had lower rate of pelvis recurrence and better 5-year rate of survival for the group of improved lateral lymph node dissection (P<0.05).Conclusion:Radical resection with improved lateral lymph node dissection may decrease the pelvis recurrence rate and increase survival rate in patients with stageⅢ lower rectal carcinoma.