The stapling procedure of hemorrhoid surgical therapy, reported from 1998, is a very good new technique especially by significantly pain reduction. One of its disadvantage is the cost of 300-400 USD/case. That is why, the author uses a modified technique by realizing a circular handsew-technique, of U or X shaped points at 1.5 cm - 2 cm above the dentate line. By good results of 72 cases, the modified handsew technique is well appreciated. The indication is for 2nd, 3rd and 4th (not too big) degree piles. For big and mixed hemorrhoid especially with circumferential prolape the modified technique is combined with Milligan Morgan procedure. Further study with randomised groups and long follow up results are needed.
Hemorrhoids ; surgery ; therapeutics

Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM.
Dendritic Cells ; Humans ; Immunotherapy ; Multiple Myeloma ; Stem Cell Transplantation ; T-Lymphocytes, Cytotoxic