A clinical trial was conducted from 6/2001 to 5/2004 at Women hospital of Hai Phong to look for efficacy of Methotrexate (MTX) in medical treatment of unruptured ectopic pregnancies. 100 patients admitted the hospital due to unruptured ectopic pregnancies with βhCG > 100mUl/ml- <10.000mUl/ml. Tubal diameter < 3cm were enrolled in study. Treatment consisted of 50mg/m2 skin of MTX injected intramusculary and all patients were followed up by utrasound and βhCG after 48 hours and then 7 days. Injection was repeated if βhCG declined less than 15% of the initial level or increased at the 7th day after the first dose. Maximum doses of MTX used were 3 courses. 71 out of 100 patients (71%) were treated with one dose of MTX, 27 with two courses (27%), and two patients with 3 courses. Success rate was 83%. Serious side effects of MTX were note, unless 20 patients had mild side effects. Pregnancy rate after treatment reached 42.8% with recurrent ectopic pregnancy rate was 4.8%.
Methotrexate ; Pharmaceutical Preparations ; Therapeutics ; Pregnancy, Ectopic