A study on 24 allergic patients due to carbamazepine (1991- 1998) was performed at Bach mai Hospital. Results showed that: - The first signs of allergy appear late(11.37+4.56 days). - Main clinical symptoms of allergy are necrosis at natural cavities, erythema, fever. - The main clinical form of allergy is Stevens-Johnson syndrome (79.16%). - Elevated ESR, SGOT, SGPT are the main changes in tests. - It takes a long time to treat allergic patients due to carbamazepine (12.61+35days) - Glucocorticoid, dimedrol, glucose and ascorbic acid solution are the common medications.
Hypersensitivity ; carbamazepine

Preliminary results of the study on allergic reaction of NSAID. Allergic patients due to antipyretics, analgesics, non-steroid anti-inflammatory drugs (1995-1999) were performed at Bach Mai Hospital. Result showed that: most anti-pyretics, analgesics, no-steroid anti-inflammatory drugs can cause allergic reactions. The first sign of allergy appeared early. Main clinical symptoms of allergy are itching, erythema, fever and urticaria. The average concentration of total serum IgE in the group of allergic patients is higher than in the group of healthy persons. Methyl prednisolon, dimedrol, glucose and ascorbic acid solutions are common medications to treat allergic patients. From 30 allergic patients, there was no death.
Hypersensitivity ; Anti-Inflammatory Agents, Non-Steroidal ; Pharmaceutical Preparations

During 1981-2000, in Bach Mai Hospital, 1,465 patients with drug allergy were consulted and treated. Among them, 9 cases died of Stevens-Johnson and Lyell syndrome. There were 121 kinds of drug allergy. 215 of health staffs suffered the drug allergy showed the risk of allergy among health staffs was higher 2.5 times.
Drug Hypersensitivity ; epidemiology ; Pharmaceutical Preparations

GC is wonderful drug to prevent and control bronchial asthma. Methods: 1026 inpatients with asthma presented at the Department of Allergy and Clinical Immunology were included in this study. Cross - sectional surveys and retrospective studies. Objectives: Study on situation of using GC of asthmatic patients. Describe adverse drug reactions of glucocorticoid to asthmatic in - patients at the Department of Allergy and Clinical Immunology. Results: All of 1026 patients used Gc. Prednisolon, solu - medrol, depersolon and pulmicort were most used medications. There were 295 asthmatic patients have side effects (28.75%) with 24 types of symptom, 15 diseases and syndromes are resulted: Cushing syndrome, gastric ulcer, diabetes, hypertension, ponosis, retarded development... Almost systemic organs of the patients were influenced negatively by Gc. It has relationship among the way to use, the time in used GC and adverse drug reactions of GC. Conclusions: GC caused many adverse drug reactions to asthmatic patients.
Asthma ; Status Asthmaticus ; Patients ; Glucocorticoids

Author studied 21 allergic patients due to specific for Gout'streatment from 1995 to 2001 at the Department of Allergology and Clinical Immunology of Bach Mai Hospital with method "cross- sectional surveys". Results showed that: - Allopurinol, colchicin and both go together are specific for Gout'streatment and It caused of. allergic reactions of 21 patients. - Main symptoms of allergic patients of specific for Gout'streatment were erythema, itching and fever The main clinical form is Erythrodermie; Allergic reations were mostly nappened late (after 24 hours); Elevated ESR, white blood cell, uremia, SGOT SGPT and proteinuria are main changes of tests. -It takes a long time to treat allergic patients (13,54 :t 10,17 days); Solution of methyl-prednisolon and dimedrol are common medications to treat this patients; No allergic patient is died due to the specific for Gout'streatment at The Departma
Gout ; Hypersensitivity ; Therapeutics

Study on 98 patients with SJS and Lyell were treated at the Department of Allergology and Clinical immunology in Bach Mai Hospital (1997-2002). SJS & TEN always occurred when patients used the ampicillin and antibiotics of beta-lactam family, carbamazepine and anti-convulsion drugs properly or not. The symptoms of SJS & TEN appeared late (1-7 days) with 9 common clinical symptoms such as mucous membrane ulcerations, erythema, bullas and fever, etc. SR, uremia, enzymes of liver cells and proteinuria went up, that were main changes in blood test and urine test of SJS & TEN patients. Treating time was long-lasting, for SJS was 14.298.83 days, for Lyell syndrome is 19.716.6 days, with 4 main drugs: methyl-prednisolon, dimedrol, glycerin borate, and 5% glucose solution. There was no dead at that time.
Stevens-Johnson Syndrome ; Epidermal Necrolysis, Toxic ; Hypersensitivity ; Pharmaceutical Preparations

Tuberculosis treatment-related allergic reactions are increasing. It influenced to therapy regimen for tubeculosis over our country. Objectives: (1) Make a list of tuberculosis treatments can cause allergic reactions. (2) Study on clinical symptoms of tuberculosis treatment allergy in tubeculosis patients. (3) Study on some of liver biochemical test. Subjects and method: 91 patients who had allergic reactions related to tuberculosis treatments presented between 1998 and 2003 in the National Hospital of Tubeculosis and Lung Diseases. Cross sectional survey and retrospective study. Results: There are 6 tuberculosis treatments related to allergic reactions: rifampicin, streptomycin, ethambutol, isoniazid, pyrazynamid and RH; Rifampicin, streptomycin and ethambutol are main cause. Most of all allergic reations happened late (after 24 hours) in patients with lung tuberculosis treated by "formula I". Out of 7 signs of allergic reaction, 3 clinical symptoms happened most are erythema, prurigo and fever. Delayed type of allergy is main part. Erythema is the main clinical form. There were no changes in AST, ALT and total bilirubin on blood test. Conclusion: Tuberculosis treatment of "formula I" are main cause of allergic reactions with various clinical symptoms and it can damage liver cells.
Tuberculosis, Pulmonary, Lung Diseases, Tuberculosis, Therapeutics, Hypersensitivity

At the Department of Allergy and Clinical immunology of Bach Mai Hospital from the year 1981 – 2003, study was performed in vivo on 1.728 patients of drug allergy and a control group of 143 healthy students without allergic history. Results showed that the positive rate of mastocyte degenerative reaction was 81.2%, of the test of lymphocyte transformation was 76.2%, applicated skin test was 66.7%. The highly accurate test such as the total IgE quantification and the determination of the number of thrombocyte in the forth of T lymphocyte were recommended for complementing, the diagnosis and for minotring the treatment of drug allergy. Methyl-prednisolon, Dimedron, vitamin C and glucose solution were the main medication for allergic control. Patients with Stevens-Johnson and Lyell syndromes required special cares such as for burn, preliminary good results were given for 100% of patients. Mean duration of the course of treatment got 9.6 6.8 days and for Stevens-Johnson syndrome 16.1  9.5 days.
Diagnosis ; Therapeutics ; Hypersensitivity ; Iatrogenic Disease

The cross sectional study was conducted in 111 patients suffered from acute urticaria due to drug allergy at the Department of Allergology and Clinical Immunology of Bach Mai Hospital from January 2001 to May 2005. Results: these patients were allergic to 120 kinds of medications; antibiotic were the leading cause of the acute urticaria with 55.8%, among which beta lactam is the most common cause; then traditional medications with 15.8% … Patients often included 2 groups: <20 and 20-39 years (34.2%), women more than men (p<0.005). The rate of oral allergy accounted for 88.3%; 50.4% of patients had allergic history. Allergy to one kind of medication 91.9%. The duration of acute urticaria was from 1 to 24 hours (48.6%). Increase of erythrocyte sedimentation rate occurred in 62.2% of patients. The duration of treatment was 6.57±3.56 days. The patients were treated with glucocorticoid and antihistamine, mainly methyl-prednisolon and dimedrol. 100% of patients recovered
Urticaria ; Hypersensitivity

At the Department of Allergy and Clinical Immunology of Bach Mai Hospital in 1981-2003 year period, 1.728 patients with drug allergy and a controll group including 143 healthy students without allergic history were enrolled into study. Almost drug had been used in consultative clinic could make allergic reaction. 128 type of medicines could make diverse allergic reactions on 1.728 patients. Among 27 groups of medicine, antibiotics were the main caused with 72.4%. The main clinical symptoms of drug allergy in 615 inpatients were itchi, fever, dizzi, uncomfortable feeling and urticaria and some dangerous symdroms as Stevens-Johnson and Lyell syndrome.
Diagnosis ; Hypersensitivity/etiology ; Iatrogenic Disease