On experimental rats, the effect of pain relieve, of neuroleptic and acute toxicity of Formula D1 was studies. The formula composes of 9 componants (Bach truat, Hoang ky, Chi thuc, Moc huong, Nghe, Cam thao, Lac tien, Bach thuoc, Huong phu). It manifests an effects of analgesic on white mouse, experimented with the method of heat plate and Koster. The formula inhibits Central nervous system, it has not acute toxicity when administered orally in dose of 73 folds of therapeutic dose
Chemistry, Pharmaceutical ; Medicine, Traditional ; Therapeutics ; drugs

Healthy rats with weight of 120-180 g were randomly divided into 4 groups. They tested the anti-acute inflamatory activity of T1 (3 -methoxy 4 hydroxy-5 bromobenzylidien para bromo anilin) and T2 (3-methoxy 4 hydroxy-5 nitrobenzylidien p-nitro anilin). The results have shown that T1 had a significant antiinflamatory activity after 2 h and 4 h of the test but had no antiflamatory activity after 6 h of the test comparing with the control. While the anti-inflamatory activity of T2 was not different from this in the control. This study concluded that the anti-inflamatory activity of derivatives of 5 bromo vanilin was better than this of derivatives of 5 -nitroanilin.
Anti-Inflammatory Agents ; analogs & derivatives

Cot khi cu was studied on experiment animals. Pain relief effect was evaluated with 1% extract, sedative and hypnotic effect was compared with hexobarbital and acute toxicity was assessed by Lichfield Wilcozon Method. Results showed that raw and processed Cot khi cu did not cause acute toxicity, with a dose of 200 folds of clinical dose. In raw and processed Cot khi cu, there is no defference in pain relief effect. Roast Cot khi cu gave a better sedative effect than the raw Cot khi cu
Acute Toxicity Tests ; Animals ; Biochemistry ; drugs

The anti-flammatory effect of Drynaria fortunei was studied on rat’s hind paw edema induced by carrageenin. Results showed that its aqueous extract in the dose of 4g/kg body weight exerts anti-inflammatory effect. Acute effect of Drynaria fortunei is exhibited through the decreased quantity of exudation and the number of leucocyte in the exudation.
Anti-Inflammatory Agents ; Animal Experimentation ; Medicine, Traditional

The effect of analgetic and anti inflammatory of Tinospora Sinensis Men were studies in the form liquid glue on experimental mice. These mice were divided into 4 groups: group 1 takes NaCl 0,9%; group 2 takes Aspegic; group 3 takes liquid glue with dose 4g/kg; group 4 takes liquid glue with dose 8g/kg. The results were: after 5 min causing pain, aspegin and Tinospora Sinensis Men relieves pain clearly. After 15 min, these two drugs also has effect vigorous (58.88 – 88.5%) compared to control group with P<0.001. Dose 4g/kg of Tinospora Sinensis Men had not effected yet acute anti inflammatory clearly. Dose higher 8g/kg can inhibit inflammatory reaction on leg of mice with 10,16% (P<0.005), less than aspegic 0.05g/kg. The conclusion: Tinospora Sinensis Men has effect relieving pain by peripheral machanism, anti inflammatory acute and relievring oedematose reaction local with dose 8g/kg
drugs ; Medicine, Traditional ; Pain ; Anti-Inflammatory Agents

Study on acute and subchronic toxicity of CP preparation (extracted from Cu Binh Voi) finding using CP preparation with 1000mg/kg mouse of dose, follow in 72 hours, not any mice died. With 30mg/kg mouse uninterrupted take in 30 days, CP preparation didn’t effect to making blood function (but reduced number of leukocyte). It exchanged effect of eliminate urea thourgh renal. It not exchanged tranxaminaza level in serum but slightly effect to sterilize function of rabit
Medicine, Traditional ; Biochemistry ; Plant Extracts

Study on ‘Cot toai bo’ (Drynaria bonii Rhizome) product was processed from fresh stem and root of Drynaria bonii Christ., collected at Lang Son from July 2003 to September 2003. Results: chemical analysis showed that Cot toai bo contains flavonoids, steroid saponins, sterols, tannins, deoxidized sugar. Total flavonoid in stem and root accounted for 0.60±0.03% and total saponin was 3.71±0.06%. After processing by traditional method, total flavonoids and saponins in processed materials reduced in comparison with raw material. Compare 2 processing methods: in rice alcohol processed material, whose chemical constituents were reduced very little but in fried material, whose chemical constituents were reduced more than raw material. Rice alcohol processed Cot toai bo had analgesic and anti-inflammatory effects better than raw material and this processing was a more appropriate method than fried method
Polypodiaceae ; Rhizome ; Chemistry

The study was carried out with healthy white mice of the strain of Swiss, weighed 202 g, fed properly in good supply of water and food. Results a pain relief and narcotic effects of the material. An intensive dose 200 times higher than usual clinical dose did not manifest toxicity in the animal
Medicine, Traditional ; Chemistry, Pharmaceutical ; Acute Toxicity Tests

Cau tich fluid extract was studied on white mice. The dose of 4 g/kg of body weigh exerts against acute inflammation and relief the pain 2 hours, 4 hours, and 6 hours after the onset of inflammation. On the experimental granuloma, Cau tich has a moderate effect on chronical inflammation. In experimental model of “hot plate” Cau tich manifests a pain relief effect centrally and peripherally
Inflammation ; Medicine, Traditional ; Chemistry, Pharmaceutical ; drugs

Introduction: To date, there has not been any systematical and experimental research aimed at indicating the effects of Morinda officinalis How on the genital organs of male rats. \r\n', u"Objectives: To determine the effectiveness of Morinda officinalis How (MOl-I) on the genital organs of male rats, to describe the changes in histology of testicles, and evaluate the testosterone concentration in mature male rats' bloods when dosed with MOH.\r\n", u'Subjects and method: Mature and immature rats were divided into 3 groups: mature rats, castrated and non - castrated immature rats. The rats have a daily dosage of MOH: 20g/kg. The above groups of rats were euthanized after 10 days; their testicles, seminal vesicles, prostates and Cowper land were weighed; specimens of histology of testicles were made; testosterone concentration in the bloods of the mature rats was measured. Results were compared amongst experimental groups. \r\n', u'Results and conclusion: Compared with the control group, MOH (dosage 20g/kg) increased the weight of testicles, seminal vesicles, prostates, and Cowper lands (p < 0.05). In mature rats, MOH increased the testosterone concentration in the blood in comparison with the control group (p < 0.05). MOH did not change the histology of testicles, diameter of seminal ducts, but it did change the rate of seminal ducts having sperm compared with the control group and the testosterone injected group (p < 0.05). \r\n', u'
Morinda officinalis How ; Genital organs ; Male rat