To obtain a prolonged-action dosage form of Ketoprofen, a technique for delaying drug release from insoluble inert matrix of ethyl cellulose was evaluated. It was incorporated with excipients such as lactose, starch, hydroxy propyl methyl cellulose. influence of lubricants on release profiles was also investigated. The best result was obtained from the formula that consists of ethyl cellulose, lactose, starch, hydroxy propyl methyl cellulose, magnesium stearate, talc, aerosil (appropriate rate) and is coated with Eudragit L 100 (1mg/cm2)
Ketoprofen ; Cyclooxygenase Inhibitors ; tablets ; Pharmaceutical Preparations

A study on 35 patients with the allergic dermatitis, ages of 41.23 treated in Friendship hospital during 5-7/2000 has shown that fucicort had a good effect in the first week and best in the second week. There was no adverse effects found. Patients tolerated well the drug.
Dermatitis, Allergic Contact ; therapy ; therapeutics

A prospective study was conducted on 35 patients (22 men and 13 women) with atopic dermatitis at the H÷u NghÞ Hospital from March 15, 2000 to May 19, 2000. Age of patients ranged from 37 to 72. Control group included 30 individuals without history of this condition and had not any sign of atopic diseases at baseline. The results showed that Staphylococcus aureus colonized in the skin of most of atopic dermatitis patients (85.7%). The more severe the condition, the higher the rate. This bacterium colonized in 100% of patients who have discharge lesions and in 100% of patients who have severe condition. S. aureus has sensitivity of 100% with vancomycine, 96.6% with fucidic acid, 93.3% with gentamycin, 73.7% with cephalothin, 63.3% with oxacilline and 56.7% with erythromycin.
Dermatitis, Atopic ; Staphylococcus aureus

The total serum IgE level and blood eosinophil count were evaluated in 44 adult patients with atopic dermatitis and were compared with 13 healthy controls for IgE level, and with 31 healthy controls for eosinophil count. It is found that both mean of IgE levels (X+/-SD=1129.86+/-984.54 IU/mL) and absolute number of eosinophils (X+/-SD = 0.857+/-0.736 G/L) were significantly elevated in comparison with control groups (p<0.001). There was closed correlation between IgE level, eosinophil count and severity of disease (r=0.60, 0.58 respectively with p<0.01). There was weak correlation between IgE level and eosinophil count with r = 0.22.
Dermatitis, Atopic ; Eosinophils

This prospective study was designed to evaluate the major and minor features of Hanifin and Rajka in 100 adult patients with atopic dermatitis. The results showed that 65% of the patients had 4 major features and 80% had 6 minor features. The specific features included itchy (100%), chronic progress (100%), history of atopic conditions (79%), lichenification in flexural areas (78%), non-specific hand dermatitis (75%), onset before 5 years of age (74%), xerosis (63%). Non-specific features included the progress has been influenced by environmental and emotional factors (100%), white dermographism (79%). Uncommon features included Denie-Morgan folds (5%) and anterior neck folds (5%). Based on these results, a minimum clinical diagnostic criteria was proposed, by which to be diagnosed with atopic dermatitis, a patient must have itching plus 4 or more followed features: history of atopic conditions, lichenification in flexural areas or eczema on face in children under 10 years of age, chronic progress, non-specific hand dermatitis, onset before 5 years of age and xerosis.
Dermatitis, Atopic ; diagnosis ; adult

21 patients with the atopic dermatitis, ages of 49.1+/-15.7 (inpatient and outpatient) in Friendship hospital and the Central Institute of Dermatology and Venerology during 9/1997- 4/2000 participated to a study. The results have shown that the absolute amount of lymphocyte CD3, CD4, the ratio of CD4/CD8 and CD19 in patients with the atopic dermatitis were insignificant different from these in control group. The amount of CD were significantly reduced but not significantly increase the ratio of CD4/CD8. There was no relation between CD3, CD4, CD8, ratio of CD4/CD8 and CD 19 with the severity of disease.
Dermatitis, Atopic ; lymphocytes

We had studied in 60 patients with herpes zoster in Friendship Hospital and recognised that: men is 83.33%, women 16.67%, mean age was 65.42 ±7.18 mean duration of viral infection was 5.7 ±2.75 days. The sites most affected were thoracic (45%), cranial (23.4%), lumbar (15%), sacral (8.3%), and others (8.3%). We also used Acyclovir to treat 60 patients with zoster and found that: Acyclovir had good result in 89.47% and the vesibullar lesions with wet, red skin still remained in 10.53% patients. Side effects of Acyclovir were: diarrhea in 8.3%, nausea in 5% and vomiting in 3.3% patients. Acyclovir did not change renal and liver functions.
Herpes Zoster ; Aged ; Therapeutics ; Pharmaceutical Preparations ; Acyclovir

BACKGROUND: Currently, it is recognized that water polluted with toxic heavy metal ions may cause serious effects on human health. Therefore, the development of new materials for effective removal of heavy metal ions from water is still a widely important area. Melanin is being considered as a potential material for removal of heavy metal from water. METHODS: In this study, we synthesized two melanin-embedded beads from two different melanin powder sources and named IMB (Isolated Melanin Bead originated from squid ink sac) and CMB (Commercial Melanin Bead originated from sesame seeds). These beads were of globular shape and 2-3 mm in diameter. We investigated and compared the sorption abilities of these two bead materials toward hexavalent-chromium (Cr) in water. The isotherm sorption curves were established using Langmuir and Freundlich models in the optimized conditions of pH, sorption time, solid/liquid ratio, and initial concentration of Cr. The FITR analysis was also carried out to show the differences in surface properties of these two beads. RESULTS: The optimized conditions for isotherm sorption of Cr on IMB/CMB were set at pH values of 2/2, sorption times of 90/300 min, and solid-liquid ratios of 10/20 mg/mL. The maximum sorption capacities calculated based on the Langmuir model were 19.60 and 6.24 for IMB and CMB, respectively. However, the adsorption kinetic of Cr on the beads fitted the Freundlich model with R values of 0.992 for IMB and 0.989 for CMB. The deduced Freundlich constant, 1/n, in the range of 0.2-0.8 indicated that these beads are good adsorption materials. In addition, structure analysis data revealed great differences in physical and chemical properties between IMB and CMB. Interestingly, FTIR analysis results showed strong signals of -OH (3295.35 cm) and -C=O (1608.63 cm) groups harboring on the IMB but not CMB. Moreover, loading of Cr on the IMB caused a shift of broad peaks from 3295.35 cm and 1608.63 cm to 3354.21 cm and 1597.06 cm, respectively, due to -OH and -C=O stretching. CONCLUSIONS Taken together, our study suggests that IMB has great potential as a bead material for the elimination of Cr from aqueous solutions and may be highly useful for water treatment applications.
Adsorption ; Chromium ; chemistry ; Kinetics ; Melanins ; chemistry ; Waste Disposal, Fluid ; methods ; Water Pollutants, Chemical ; chemistry ; Water Pollution, Chemical ; prevention & control ; Water Purification ; methods