From 1992 to 1997, 982 calculus in the upper urinary tract (UUT) was removed. There were 10 acute renal failure and 75 chronic renal failures. The study deserves special commentaries. Renal failure occurred in both groups patients bilateral calculi (group I) and calculus in the single kidney (group II). The members of chronic renal failure were much higher than that of acute renal failure. Renal failure in group II was 2.24 time higher than in group I. The risk was equal for both sex. In group I, the rate of renal failure increased with long history of disease and patients in very short time. Among high - risk factors for renal failure we noted: calculus in many location, bilateral Staghorn calculus multiple bilateral calculi or calculi with calculi in the single kidney, calculi urinary tract infection. Roentgenography, ultrasound, and radioisotope examinations were used as non-invasive techniques for those patients
Urinary Calculi ; Kidney Failure ; diagnosis ; complications

Absorbed DTP vaccines in the same Lot (produced by IVAC, Nha Trang) were kept at 4°C, -5 +/-10oC, -20°C on 2, 3 and 6 hours. After being thawed completely, the vaccine containers were vigorously shaken and the contents were examined for physical changes. The results showed that the containers kept at 4oC had no physical changes; the containers kept at -5 +/-10oC, 20°C for 6 hours had significant changes such as agglomeration, floccules or granular matter, and sedimented rapidly. It is suggested that structure of aluminum adjuvant in DTP vaccine is changed. The containers kept at -5 +/-10oC, -20°C for 6 hours can be considered as the positive control and the shaking test can be used to determine the previous freezing of adsorbed DTP vaccines.
Diphtheria-Tetanus-Pertussis Vaccine ; Freezing

Quality of RP5 pertussis vaccines for National Reference was tested and its potency was also calibrated in comparison with the International Standard of Pertussis Vaccine. The results showed that the candidate for National reference RP5 pertussis vaccine lot was met to the quality requirements after being freeze dried. The homogenicity in dry weight, residual moisture, potency and stability of its potency make it became as the first National Reference standard pertussis.
Pertussis Vaccine ; Vaccines

The study was performed in two children groups after 3 - 4 years receiving intradermal immunized BCG vaccine with the different doses of 0.05mg (216 children: group I) and 0.025mg (232 childern: group II) at some communes in Tu Son, Bac Ninh province and Thanh Tri district, Hanoi city. Results showed that the children malnutrition rate and tuberculosis exposure were the same and there was no statistically significance (P>0.05) in both groups. There were children with IDR (+), IDR > 15 mm, IgM, IgG and IgM antituberculosis, PCR (+) in the rate of children, delayed sensitivity reaction with tuberculin, the abnormal lung X-ray, IgG and IgM antibodies, and the rate of PCR (+). The rate of morbidity of tuberculosis in two children groups was the similar (0.46% and 0.43%, P=0.519). There was no case with meningitis and no statistical difference between two tuberculosis cases.
Tuberculosis ; Child ; BCG Vaccine ; Vaccination

Immunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic reprogramming, and secretion of proinflammatory mediators. This state primarily manifests during the aging process but can also be induced in various pathological conditions, encompassing chronic viral infections, autoimmune diseases, and metabolic disorders. Age-associated immune system alterations extend to innate and adaptive immune cells, with T-cells exhibiting heightened susceptibility to immunosenescence. In particular, senescent T-cells have been identified in the context of metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Recent investigations suggest a direct link between T-cell senescence, inflammation, and insulin resistance. The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic diseases, particularly through inflammation-mediated insulin resistance. Consequently, senescent T-cells are emerging as a noteworthy therapeutic target. This review aims to elucidate the intricate relationship between metabolic diseases and T-cell senescence, providing insights into the potential roles of senescent T-cells in the pathogenesis of metabolic disorders. Through a comprehensive examination of current research findings, this review seeks to contribute to a deeper understanding of the complex interplay between immunosenescence and metabolic health.

Immunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic reprogramming, and secretion of proinflammatory mediators. This state primarily manifests during the aging process but can also be induced in various pathological conditions, encompassing chronic viral infections, autoimmune diseases, and metabolic disorders. Age-associated immune system alterations extend to innate and adaptive immune cells, with T-cells exhibiting heightened susceptibility to immunosenescence. In particular, senescent T-cells have been identified in the context of metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Recent investigations suggest a direct link between T-cell senescence, inflammation, and insulin resistance. The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic diseases, particularly through inflammation-mediated insulin resistance. Consequently, senescent T-cells are emerging as a noteworthy therapeutic target. This review aims to elucidate the intricate relationship between metabolic diseases and T-cell senescence, providing insights into the potential roles of senescent T-cells in the pathogenesis of metabolic disorders. Through a comprehensive examination of current research findings, this review seeks to contribute to a deeper understanding of the complex interplay between immunosenescence and metabolic health.

Immunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic reprogramming, and secretion of proinflammatory mediators. This state primarily manifests during the aging process but can also be induced in various pathological conditions, encompassing chronic viral infections, autoimmune diseases, and metabolic disorders. Age-associated immune system alterations extend to innate and adaptive immune cells, with T-cells exhibiting heightened susceptibility to immunosenescence. In particular, senescent T-cells have been identified in the context of metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Recent investigations suggest a direct link between T-cell senescence, inflammation, and insulin resistance. The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic diseases, particularly through inflammation-mediated insulin resistance. Consequently, senescent T-cells are emerging as a noteworthy therapeutic target. This review aims to elucidate the intricate relationship between metabolic diseases and T-cell senescence, providing insights into the potential roles of senescent T-cells in the pathogenesis of metabolic disorders. Through a comprehensive examination of current research findings, this review seeks to contribute to a deeper understanding of the complex interplay between immunosenescence and metabolic health.

Immunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic reprogramming, and secretion of proinflammatory mediators. This state primarily manifests during the aging process but can also be induced in various pathological conditions, encompassing chronic viral infections, autoimmune diseases, and metabolic disorders. Age-associated immune system alterations extend to innate and adaptive immune cells, with T-cells exhibiting heightened susceptibility to immunosenescence. In particular, senescent T-cells have been identified in the context of metabolic disorders such as obesity, diabetes, and cardiovascular diseases. Recent investigations suggest a direct link between T-cell senescence, inflammation, and insulin resistance. The perturbation of biological homeostasis by senescent T-cells appears intricately linked to the initiation and progression of metabolic diseases, particularly through inflammation-mediated insulin resistance. Consequently, senescent T-cells are emerging as a noteworthy therapeutic target. This review aims to elucidate the intricate relationship between metabolic diseases and T-cell senescence, providing insights into the potential roles of senescent T-cells in the pathogenesis of metabolic disorders. Through a comprehensive examination of current research findings, this review seeks to contribute to a deeper understanding of the complex interplay between immunosenescence and metabolic health.

Anaplasma marginale and A. platys were detected and characterized (16S rDNA sequence analysis) from dairy and indigenous cattle, and the latter in domestic dogs in Vietnam. A phylogenetic tree was inferred from 26 representative strains/species of Anaplasma spp. including 10 new sequences from Vietnam. Seven of our Vietnamese sequences fell into the clade of A. marginale and 3 into A. platys, with strong nodal support of 99 and 90%, respectively. Low genetic distances (0.2–0.4%) within each species supported the identification. Anaplasma platys is able to infect humans. Our discovery of this species in cattle and domestic dogs raises considerable concern about zoonotic transmission in Vietnam. Further systematic investigations are needed to gain data for Anaplasma spp. and members of Anaplasmataceae in animal hosts, vectors and humans across Vietnam.
Anaplasma marginale ; Anaplasma ; Anaplasmataceae ; Animals ; Asian Continental Ancestry Group ; Cattle ; DNA, Ribosomal ; Dogs ; Humans ; Phylogeny ; Trees ; Vietnam

Sphaeranthus africanus is commonly used as a traditional remedy for sore throats and pain treatment in Vietnam. The aerial parts have been studied for its anti-inflammatory and anti-proliferative properties. However, the antioxidant and antidiabetic potential of the plant has not been explored. In this work, hydrophilic extracts of the plant's aerial parts were prepared in order to investigate its antioxidant and anti-diabetic properties. Also, the cytotoxicity of the root was evaluated and compared to that of the aerial parts. All of the extracts inhibited lipid peroxidation with IC 50 values ranging from 2.05 to 3.56 µg/mL, indicating substantial antioxidant activity. At an IC 50 value of 4.80 μg/mL, the 50% ethanol extract exhibited the most potent inhibition of α-glucosidase. The cytotoxic activity of root extracts is 2 to 5-fold less than that of the aerial parts. Nevertheless, dichloromethane and ethyl acetate extracts of the root demonstrated a selective effect on leukemia cells, with no harm towards the normal HEK-293 cell line. This work provides a scientific support for the antioxidant and antidiabetic activity of the plant. Hence, it may find a promising material for the development of novel antioxidant and antidiabetic agents. More research can be conducted on the phytochemistry and anticancer activities of the plant’s root.