The study involved 60 patients with acute leukemia at B¹ch Mai Hospital between June and December 2000. Among these, there were 33 males and 27 females. Findings: 65% of patients have hemorrhage; 88.3% have reduction in platelet count. There was the correlation between reduction in platelet count and symptoms of hemorrhage, with the rate of hemorrhage was 84.6% when number of platelet reduced by less than 30G/l. 46% of patients have endogenous dyscoagulation and 23% have exogenous dyscoagulation. DIC was found in 28.3% of patients. Hemorrhage in acute leukemia also related to dyscoagulation.
Leukemia ; Blood Coagulation Disorders

During two years we carried out the technique of splenectomy for 10 patients with idiopathic aplastic anemia AA. All patients were refractory after 3 courses of immunosuppressive drugs and androgen. Investigation on clinical aspects and hematological parameters after splenectomy, we found that all blood cells counts tend to be increased forward recovery. We are now continuing to further evaluation on hematopoiesis and lymphocytic subsets distribution, in order to select patients group, suitable to this technique.
Anemia, Aplastic ; Hematology

Recently, gout prevalence is increasing, but in Vietnam the knowledge of gout is not enough. Objectives: (1) Describe clinical X-ray manifestations of bone and joint damage related to chronic gout. (2) Identify suggestive factors to make diagnosis of bone and joint damage related to chronic gout. Methods: The cross-study included 54 patients with chronic gout presented in the Rheumatology Department of Bach Mai Hospital from March-2003 to June-2004. All of them were diagnosed gout according to the criteria of Bennett and Wood-1968 and had tophi nodules. Results: The common findings are polyarthritis (79.6%), lower limbs are involved more common than upper limbs (75-80% of patients had ankle, knee, first metatarsophalangeal joint arthritis) and symmetric arthritis (60% to 70%). All patients had a history of acute gout. 80% of patients had chronic gout presented in X-ray images, including joint space narrowing, erosion, new bone formation at the edge of a gradually expanding tophus. Important factors can be considered of chronic gout were male, middle age, symmetric arthritis of lower limbs, tophi nodules. Conclusions: Suggestive factors and X-ray of bone and join contribute to earlier diagnosis of bone and joint damage in chronic gout.
Gout ; Arthritis ; Juvenile Rheumatoid ; Bone and Bones

With 4-7 cases of Rhinonasal polypsis in Eto-rhino-laryngologic center, from January 1998 to January 2001, in the age of 16-60 years. The ethmoidectomy via endoscopic technique and receive high efficacy result: 97% decrease nasal obstruction post op, 0% of orbital and intracranial complications, and specially 27% has appeared the minimal recurrent polyps on the anterior ethmoid which did not remove, just only use the steroid spray. Preparing the pre-op period with antibiotic, anti-inflammatory 93.7% and planned regularly patient's examination each month per year. Others factors such as asthma 13%, allergic zhinitis 24%, tobacco 15% were well studied to improve the result of the endoscopic ethmoidectomy and to limit the recurrent polyps
Endoscopy ; surgery ; therapeutics ; Ethmoid Bone

A study was performed on 82 cases, among which, 50% with fast heart rhythm disorders at Quang An Hospital. Results: The most common risk factors included: exhausted or moved activities. Fast heart rhythm disorders were more common in patients with hypertension and heart valvular disease. Common symptoms included: headache, dyspnea. More severe symptoms: unconsciousness, convulsion, enuresis, systolic blood pressures < 90 mmHg. There were 13.41% of cases could not cut off fast heart rhythm disorder, left the hospital within 24 hours with death prognosis.
Arrhythmias, Cardiac ; Diagnosis ; Therapeutics

Synthesis of 3 derivatives of vanilin and 15 derivatives of sulfamide have been carried out. The structures of the synthesized compounds have been determined by IR, UV, MS spectroscopy. Their antibacterial and antifungal effects have been tested
Biological Markers ; Anti-Bacterial Agents ; Pharmaceutical Preparations

Background: Tophi gout refers to the condition, where consistently high level of uric acid in the body causes the deposition of uric acid or monosodium urate crystals on the joints. Objective: To describe clinical and subclinical features of tophi gout. Subjects and method: A study conducted in 51 patients with tophi gout (according to Bennett-Wood criteria - 1968) in Department of Rheumatology, Bach Mai hospital, from February 2005 to February 2006. This was a cross-sectional prospective study. Results: The average time of tophi appearance lasted 5.3 \xb1 5.7 years. The average number of tophi was 4.5 \xb1 3.9. The most common positions of tophi were tarso - metatarsal - phalangeal joints and elbow joints (43-47%). 100% had gouty arthritis (in which 66.6% > 4 joints), 50-55% involved tarso - metatarsal - phalangeal joints (43.1% had deforming joints). On X-ray, 62.7% cases has injuries, para-articular erosions and overhanging margins (62.5%), joints space narrowing (71.9%), proliferation osseous change (43.8%). Renal stones examined by ultrasound were 41%, renal failure 24.6%. Blood analysis showed hyperuricemia (88.2%), hypertriglyceridemia (54.9%), hyperglycaemia (13.6%). Conclusions: Common features tophi gout were injuries in tarso - metatarsal - phalangeal joints; gouty polyarthritis over 4 joints. X-ray images showed para-articular erosions, joints space narrowing, proliferation osseous changes.
Gout/ pathology ; diagnosis

Background: Gougerot-Sj\xf6gren syndrome is an autoimmune disorder with two remarkable symptoms such as dry eyes and dry mouth. Objective: To study the symptoms of dry mouth of Gougerot-Sj\xf6gren syndrome after rheumatoid arthritis; To evaluate clinical and subclinical manifestations of dry mouth. Subjects and method: A prospective, descriptive, cross-sectional study included 160 patients with rheumatoid arthritis, who treated at Department of Rheumatology of Bach Mai hospital, from 1998 to 2003. The patients were divided into 2 groups: 60 patients with Gougerot-Sj\xf6gren syndrome and 100 patients without Gougerot-Sj\xf6gren syndrome. Results: The average age of patients with Gougerot-Sj\xf6gren syndrome was 54.55 \xb1 10.91 years. The mean time of having dry mouth was 8.65 \xb1 8.39 months. Clinical manifestations of dry mouth were sensation of dry mouth (90%), lost of saliva (80%), drink a lot of water while eating (58.3%), enlargement of parotid glands (15%). Degrees of dry mouth were mild and moderate (36.7%), severe (53.3%). 93.3% of patients decreased total salivary flow.82% of patients had 3 and 4 anatomopathologic stages according to Chilsom classification. Conclusion: Incidence of symptoms of dry mouth was higher significantly in the rheumatoid arthritis patients with Gougerot-Sj\xf6gren syndrome than those without Gougerot-Sj\xf6gren syndrome.
Arthritis ; Rheumatoid/ pathology ; diagnosis ; Sjogren's Syndrome/ pathology ; diagnosis ; Xerostomia/ pathology ; diagnosis

Background: PDA is an especially common pathological condition in premature neonates because of the anatomical structural immaturity of the cardiovascular system. There are evidence for the effectiveness of ibuprofen for closing persistent ductus arteriosus, with few adverse effects. Objectives: To determine whether oral ibuprofen treatment is effective and safe in the closure of PDA in premature infants with respiratory distress syndrome. Subjects and methods: The prospective study was conducted on premature newborns with PDA who were presented at the Department of Neonatology, National Hospital of Pediatrics. Results: A total of 32 neonates were eligible for the study. Ductal closure was achieved in 22 newborns (68.6%), the ductus was persistent after 6 doses in 8 cases (25.1%), 2 newborns (6.3%) suffered from ductal reopening after closure (after 1 and 2 doses). PDA closure was achieved with 1 dose of ibuprofen in 7 cases, 2 doses in 9, 3 doses in 4 and more than 4 doses in 4 cases. The survival rate was 81.2% (26 out of 32). 6 patients (18.8%) died from severe respiratory distress and very low birth weight (2 cases), Klebsiella sepsis (4 cases). Mortality is higher in the closure failure group (p<0.05). Conclusions: Oral ibuprofen suspension can be considered as an effective and safe alternative for PDA closure in premature newborns. Larger comparative studies is required to confirm these results.
Persistent ductus ateriosus ; Premature newborn.

Background: Multiple myeloma is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance to plasma cell leukemia. Objective: To evaluate the effectiveness in treatment of multiple myeloma with VAD. Subjects and method: A study included 26 patients with multiple myeloma diagnosed according to Tubiana - 1993 criteria, who treated by VAD at Bach Mai Hospital, from January 1998 to December 2006. This was a retrospective combined to longitudinal follow-up examination study. Results: Response rate to treatment was 75%, complete response rate was 41.7%. Remission rate was 91.67%, complete remission rate was 66.7%. The parameters such as hemoglobin, speed of blood precipition in the first hour, globulin, and creatinine changed statistically significant after treatment. The average survival time of the patients was 30.13 \xb1 4.8 months. Survival rate of 1 year after diagnosis was 80%, at 3 years after diagnosis was 26.67% and more than 5 years after diagnosis was 6.67%. Conclusion: VAD had relatively good results in treatment of multiple myeloma.
Multiple Myeloma/ therapy