In this study, 48 long-term exposed people with polychemicals (the male/female ratio is 1/3, the age from 23 to 44): such as organic and iso-organic acids: benzene, toluene and their coequals were investigated. 17 normal people not exposed with polychemicals as the control group. Results were shown following: quantity of erythrocyte was lower than control group but not significantly. Leucocytes especially neutrophils reduced significantly (p<0.001). 15/48 cases (30%) appereared lymphoblast. There is no difference in platelet between studied group and control group
Chemistry ; Diagnosis ; Erythrocytes ; Blood Platelets

Study on 48 people, of whom 16 are male and 32 are female, from 23 to 44 years old. They were long exposed with poly-chemicals, such as organic and iso-organic acids: benzene, toluene and their coequals. The parameters have been used: phagocyte capablity and phagocyte index of neutrophils; E, rossett formed T cells. The results showed that: Phagocyte capability and phagocyte index of neutrophils decreased significantly comparing with control group (p<0.001)
Chemistry ; Allergy and Immunology ; Epidemiology

20 patients with acute leprosy, 12 patients with chronic hepatitis, 34 patients with acute myelogenous leukemia, 48 patients with pharynx cancer. 31 normal healthy persons in the control group. Immune-complexes were fixed quantity by 2 methods: precipitating the immune-complexes with PEG having molecular weight 6.10¬3 and better method. Immune-complexes (+) were identified on acute leprosy, chronic hepatitis and acute diseases with the ratio of positive differences depending on disease, stage and the character of applying technique
Leprosy ; Hepatitis, Chronic ; Pharyngeal Neoplasms ; Leukemia, Myeloid, Acute

115/400 Muong minority pupils of boarding school in Hoa Binh province, all studied subjects have 3 genarations of Muong minority (grandparents, parents and themshelves being Muong minority), from 15 to 19 years old. Using Sero check product of USA to examine the ratio of HBsAg. Results: 19.05% of the boys having HBsAg(+), 13.38% of the girls having HBsAg(+). So the ratio of HBsAg(+) in girls are lower than in boys but it is not significant. The ratio of HBsAg(+) at the age of 15 is 19.61%, the age of 16-17 is 14.74% and the age of 18-19 is 16.67%, there is not significant between groups
Hepatitis B virus ; Epidemiology ; Pupil

The solid dispersion system (SDA) of dihydroartemisinine (DHA) with PEG 400, PEG 1540, PEG 4000, PEG 6000 and Tween 20, cremophor EL, PEG 400 stearate as cocarrier were prepared. the experimental results showed that the release rate of DHA from suppository base was greater than the semi-synthetic triglyceride base and the physico-mixture
Sesquiterpenes ; Suppositories

66 strains of heamophilus influenzae and 50 strains of streptococcus pneumoniae isolated from nasopharyngeal aspirates from 161 patients under 5 years old with ARI at the Viet Nam - Cu Ba Hospital, Ha Noi, during 9/1997 to 9/1998. 13 antibiotics were tested using the disk diffusion method. H.influenzae is still susceptible to cephalosporins, aminoglycosides, quinolones (95-100%). S.pneumoniae is also susceptible to cephalosporins (82-100%).
Respiratory Tract Infections ; child ; Helicobacter pylori

The objectives of this study were to 1) compare shelf lives of imported versus domestically produced drugs, both as filed with the Drug Administration of Vietnam and as recorded on the drug labels in the market; and 2) review the compliance with expiry dates in 30 selected pharmacies in Hanoi. This retrospective study included 3480 imported and 4519 local drugs in the register files together survey of 1069 local and 1089 imported drugs in private pharmacies in Hanoi. The results showed that 1) frequency of local drugs expiry date in register files was higher than those in real market (97.32% vs. 88.44%, respectively) and 2) the imported drugs on the average have a shelf life twice as long as domestically produced ones. There were still an average of 2.18% of the above mentioned drugs list found in the pharmacies that was out of shelf life. The findings suggest that domestic producers tend to indicate shelf lives that are significantly shorter than those of the foreign manufacturers, and that there may be a need for more close supervision of the regulations concerning shelf life of pharmaceutical products at the pharmaceutical sector.
Pharmaceutical Preparations ; Health Care Sector

In the pharmaceutical Branch, drug quality is always the first concern. For last years, the enterprises have been continuously invested for manufacturing facilities to attain GMP standard. However, Only GMP standard is not enough, one of factors related with drug quality is conservative condition, which have not properly noted.
diagnosis ; Pharmaceutical Preparations

Over 3 years, the number of pharmaceutical drugs suspended from distribution system by the Drug Administration of Vietnam is 142 drugs in 1997, 103 drugs in 1998, and 11 pharmaceuticals in 1999. Analyzing the list of these pharmaceuticals reveals that:* About 70% drugs suspended from existing distribution system have a long remained time in expiry date, meaning that these products could not meet technical specifications after manufacturing date. More than 75% suspended pharmaceuticals do not meet quality standards, especially those related to quantitative assay. Therefore, the instability of quality remains the major reason for pharmaceutical drug suspension. *Vitamin and traditional drugs are of the two pharmaceutical groups, which have low stability of quality. In 1999, most of drugs contained Vitamin B12 were under rank of the technical specification. Traditional medicines were suspended for not reaching standards on microbiology, on taking a look of outward appearance, and for containing chemicals that do not register in the formulation. There should have some recommendations for manufactures and managers to improve quality of pharmaceuticals distributed in the market
Pharmaceutical Preparations ; Drug Stability

The research was done to monitor the stability of quality, which are currently distributed in the market. The sample size is of 136 drugs with expiry date, which are selected from retail pharmacies in Hanoi. These 136 drugs represent both domestic-made and imported products, different kinds of pharmaceutics and various groups of pharmacology. Results show that 11.0% of 136 studied pharmaceuticals do not meet the technical specifications. Among this, 7.4% fail to meet standards on quantitative assay. The rate of domestic made pharmaceuticals under its quantitative assay is twice higher than imported ones. Vitamin and traditional products are of the two drug groups having low stability. Almost drugs currently sold in the market have long expiry. However, there remains a considerable ratio of pharmaceuticals drugs under the quality standards.
Pharmaceutical Preparations ; Drug Stability ; Marketing