Study on 171 patients who had metastasis cervical lymph nodes (132 males, 39 females) caused by head – neck neoplasm or unknown causes were diagnosed and surgery treated at Hospital K, Ha Noi from Dec 1998 to Jun 2001. The results showed that: the clinical features can used to evaluate metastasis and to be basic for treatment strategy such as: site, size, density, number, mobility, characters of skin on node’s surface. It is emphasized that cytology biopsy is very effective method in diagnosing metastasis cervical lymph nodes.
Head and Neck Neoplasms ; Neoplasm Metastasis ; Diagnosis

We report the results of morphological study of cervical lymph node metastasis of unknown primary tumor at K Hospital from January 1999 to December 2000. Cytological diagnosis had true positive rate in 69.4% false positive rate in 16.6% and false negative rate in 13.8%. The most common histological types are undifferentiated carcinoma (36.3%) and nonkeratinizing squamous cell carcinoma (30%). Immunohistological study is very helpful in the confirmation of epithelial nature of undifferentiated carcinoma
Lymph Nodes ; Neoplasm Metastasis ; neoplasms ; anatomy & histology

Geographical and racial factors constitute important distinctions between Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C), but no study has been conducted in Vietnam. Forty-one children with KD from January 2018 to July 2020 and 42 with KD/MIS-C from August 2020 to December 2022 were included in this study. Of the patients, 52.3% were aged between 12 and 35 months. Only two were aged over 5 years, and both were belong to the KD/MIS-C group. A 59.5% of the patients were male. Apart from fever, all symptoms tended to be more frequent in patients with KD/MIS-C. The prevalence of diffuse skin rash, hand and foot edema or erythema and gastrointestinal signs was significantly higher in patients hospitalized with KD/MIS-C. There was no significant difference in laboratory findings between the two groups. Coronary artery dilation was more frequently observed in patients with KD/MIS-C compared to those with KD (40.5% vs. 14.6%, P = 0.009).

Objective: To examine the in vitro and in vivo anti-inflammatory effects of the alkaloid enriched extract (ELA) from the roots of Eurycoma longifolia. Methods: The in vitro antiinflammatory effects of ELA were evaluated by examining its inhibitory activities against nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expressions in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The level of NO produced in the culture media was determined by Griess method. The iNOS and COX-2 protein expressions were analyzed by Western blot. The in vivo effect of ELA was evaluated on LPS-induced septic shock in mice model. Mice mortality was monitored for 5 days after injection of LPS. The chemical contents of the ELA were determined by using various chromatographic and spectroscopic techniques. Results: The ELA was found to exhibit a significant anti-inflammatory effect in both in vitro and in vivo models. The results demonstrated that ELA dose-dependently inhibited LPS-induced NO production as well as the protein iNOS and COX-2 expressions. In the septic shock model, ELA dose-dependently protected mice from LPS-induced mortality. Further study on the isolated components of ELA indicated that 9,10-dimethoxycanthin-6-one may contribute significantly to the anti-inflammatory effects of the extract. Conclusions: These results suggest that ELA exhibits the anti-inflammatory activity via suppression of pro-inflammatory mediators such as NO, iNOS, and COX-2 and protects mice from LPS-induced mortality in septic shock model.