Study was carried out on 115 patients with breast cancer stage II, IIA who were treated by mastectomy and responded to scanlon at Hue Central Hospital. Results shơed that among them, 21.7% had metastatic recurrence by 5 years. The common recurrence was in chest wall (3.4%). There was relationship between metastatic recurrence and metastatic nodes under armpit. Metastatic recurrence was high when there were node metastasis under armpit with I, II degree. Metastatic recurrence related to clinical and histological period. Overall, 60-month survival rate was 68.2%. Patients with stage IIA have highest survival rate (85.7%). Metastatic lump under armpit related to survival time. 88.7% patients without metastatic lump under armpit had 5-year survival. The 5-year survival rate in patients with metastasis in degree I was 62,4%. The smaller tumor is, the higher 5-year survival rate is
Breast neoplasms

Background: Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods: We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. Results: BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. Conclusions In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems.