To report the efficacy and safety of transsphenidal approach in a series of patients with pituitary adenoma, ninety-one consecutive patients undergoing transsphenoidal surgery of a pituitary adenoma at neurosurgical department, Cho Ray Hospital from January 2001 to June 2003 were included in this study. Postoperative results were analyzed. Total removal rate was 24.2% and partial removal rate was 7.7%. There were 4 patients had rhenorrhea and meningitis. Two patients died because of surgery. Normalization of visual defect was good. Transsphenoidal surgery is an effective and safe treatment for most patients with pituitary adenoma and could be considered the first choice therapy in most of the cases. Sublabial transseptal approach is suitable for our conditions.
Pituitary Neoplasms ; Surgery ; Therapeutics

The clinical manifestations, the endocrine examinations and imaging features (MRI) of 91 patients with pituitary adenomas who had undergone transsphenoidal microsurgery from 1/2001 to 6/2003 were analyzed. The patient population was 49.5% female and 50.5% male. Mean age was 40.4 years.71 patients (78%) experienced decreased visual acuity, 67 patients (73.6) experienced headache. The most frequent tumor type was clinically nonfunctioning adenoma (50%), followed by prolactin-secreting adenoma (34.1%), growth hormone-secreting adenoma (13.2%) and last adrenocorticotropin-secreting adenoma (7.7%). there were 86 macro adenomas (94.5%) and in 13 patients (14.3%) the tumor invaded cavernous sinus. mean height was 33.05 mm, length was 26.58mm and width was 29.71mm. Conclusions: Clinical manifestations of pituitary adenomas are the result of excess hormone secretion (acromegaly, hyperprolactinemia, hypercortisolism...) and to compression of the surrounding structures (headache, visual disturbance and ocular movement palsy). The endocrine examinations are very important for diagnosis and treatment. MRI is the first choice.
Pituitary Neoplasms ; Diagnosis

The author reported 37 cases of pituitary adenoma operated in Department of Neurosurgery, Cho Ray hospital during the period of 30 months. Pitutary adenomas occupated 5.4% of all intracranial tumors. They occurred equally in both male and female and dominated at 30-40 of the age. The most common symptoms was visual disturbance with 57.1% had atrophy of optic nerve and endocrinological disturbance with amenorrhea (7 cases), acromegaly (4 cases), diabetes and galatorrhea. Endocrinological investigation indicated that the hyperprolactinaemia is a main disturbance (14 cases). Treatment results were not so good with 13.5% of bad results and dead. The author also discussed about the classification of pituitary function and the role of modern diagnostic equipments allowing earlier diagnosis. The surgical treatment was simple with the mainly applying of transcranial approach.
Pituitary Neoplasms ; Surgery ; therapeutics

Fat submucous injection into the vocal cord for treating unilateral vocal cord paralysis is a simple and effective technique. It can restore vocal cord function. This technique can be performed easily with the conventional modified instruments
Vocal Cord Paralysis ; therapeutics ; Adipocytes ; infection

Study on the isolation, structure elucidation 2 saponins and antibacterial, antifungal activities and cytotoxicity of saponins from roots of Momordica cochinchinesis Spreng, 4-5 years of age and collected at Tay Ninh in June 2002. Results: 2 saponins of oleanolic acid group were isolated and elucidated from BuOH extract of the root of Momordica cochinchinensis Spreng extraction were momordin Ib and momordin. Saponin's structure was determined by spectrum method and was compared with published data. The results showed that both of saponins have strong antibacterial to E.coli, B.subtillis, and S.aureus without cytotoxicity in the three experimental cell lines
Saponins ; Momordica ; Plant Roots

components and biological properties of seed and root of Momordica cochinchinensis (Lour) spreng in Vietnam showed that: the content of lipid in seed nucleus is very high 56%, seed membrane 23%, root 1.73%. Alkaloid exists in seed nucleus, not exist in seed cover and root; tanin was much in seed nucleus and little in seed cover and root; glycoside was much in seed cover, root and little in seed nucleus; flavonoid was much in seed nucleus, little in seed cover and root; saponin was much in root and little in seed nucleus and seed cover. Saponin in Momordica cochinchinensis (Lour) spreng can inhibit different kinds of virus and microorganisms. Extracted material and solvent rate decided antivirus and antimicroorganism activities of saponin
Plant Components ; Momordica ; Investigation into the organic

32 patients with retraction pocked in different stages. Patients had clinical examination, otolaryn endoscopy and having tests such as: hearing measure, impedance audiometry and X ray. The main aim of treatment was to recover the ventilation of recessus epitympanicus but there was not any complete surgery method, each stage required the different techniques. Using surgery method on ventilation tube combined with a cartilage placed in the tympanic cavity in order to against the adhesion of otopiesis had effectiveness higher than simple technique
Diagnosis ; Otorhinolaryngologic Diseases ; Otolaryngology ; Therapeutics

A study on 32 retraction pocked patients at various stages showed that: each stage of the retraction pocked should be done by one kind of technique. Four cases were treated by ventilation tube alone and 21 cases treated by ventilation tube combining with a cartilage placed in the tympanic cavity gave best result, 7 cases treated by ventilation tube combining with open the above ear . Ventilation tube alone did not improve hearing as well as the recovery of eardrum at surgery position. Ventilation tube combining with a cartilage placed in the tympanic cavity to prevent eardrum attack gave best results
retraction pocked

Several theories have been advanced to explain the formation of primary acquired or attic refraction Cholesteatomas including invagination of the pars flaccida, basal cell hyperplasia, otitis media with effusion, and perforation of the pars flaccida membrane with epithelial ingrowth. The study suggests it is the VA to be the cause of the otitis media with effusion and the attic Cholesteatomas.
cholesteatoma ; otitis media

Between 1978 and 1995, 63 patients with facial nervous palsy were treated. From them, 60 cases have petrosal origin and 3 cases - extra petrosal origin, including otitis, especially otitis with cholesteatoma, Bell paralysis, trauma (temporal bone fracture, frequently involving facial nerve). Among them 40 cases required surgical exploration of the facial nerve. 20 cases were treated by medicines.
Therapeutics ; Facial Paralysis