INTRODUCTIONIn this study, we sought to determine whether insulin resistance, which is investigated by homeostatic modelling, is related to slow coronary flow (SCF).

MATERIALS AND METHODSA total of 24 patients with SCF (4 females/20 males, mean age 47 +/- 12 years) and 32 patients with normal coronary artery (10 females/22 males, mean age 52 +/- 12 years) were included in the study. Baseline glucose, insulin and plasma lipid levels were measured. A standard oral glucose tolerance test (OGTT) was performed and post-challenge insulin levels were also measured. The index of insulin resistance was calculated with the homeostatic modelling [homeostatic model assessment for insulin resistance index (HOMA-IR)].

RESULTSThere were no differences between the 2 groups with regard to age, lipid levels, blood pressure levels, history of smoking, fasting and post-challenge plasma glucose. Baseline insulin levels were augmented in the SCF group (9.64 +/- 5.93 vs 7.04 +/- 3.26, P = 0.041). HOMA-IR levels were not different between the study groups (2.20 +/- 1.44 vs 1.69 +/- 0.86, P = 0.129). Manifest insulin resistance was significantly higher in the CSF group as compared with the control group (25% vs 3%, P = 0.01).

CONCLUSIONManifest insulin resistance is seen more frequently in patients with SCF.

Blood Flow Velocity ; Blood Glucose ; analysis ; Blood Pressure ; Body Mass Index ; Coronary Circulation ; physiology ; Female ; Glucose Tolerance Test ; Homeostasis ; Humans ; Insulin ; blood ; Insulin Resistance ; physiology ; Lipids ; blood ; Male ; Middle Aged ; Models, Biological