Neonatal alloimmune neutropenia (NAN) is an uncommon disease of the newborn provoked by the maternal production of neutrophil-specific alloantibodies, whereby neutrophil IgG antibodies cross the placenta and induce the destruction of fetal neutrophils. Affected newborns are usually identified by the occurrence of bacterial infections. The most frequent antigens involved in NAN are the human neutrophil antigen-1a (HNA-1a), HNA-1b, and HNA-2a. We report a neonate who was delivered at 36 weeks and had a severe neutropenia but who responded well to recombinant human granulocyte colony-stimulating factor (rhG-CSF). Anti-HNA-1a antibody was identified by mixed passive hemagglutination assay in both the sera of the baby and the mother. The baby had HNA-1a and HNA-1b but the mother had only HNA-1b on granulocytes. This is the first Korean report of NAN in which the specificity of the causative antibody was identified.
Pregnancy ; Neutrophils/immunology ; Neutropenia/drug therapy/etiology/genetics/*immunology ; Maternal-Fetal Exchange/immunology ; *Isoantigens/genetics ; Isoantibodies/*blood ; Infant, Newborn ; Immunoglobulin G/blood ; Humans ; Granulocyte Colony Stimulating Factor, Recombinant/therapeutic use ; Genotype ; Female ; DNA/genetics ; Base Sequence ; Antibody Specificity ; Adult