1.Neurobiology of Resilience to Cope Against the Life Adversity.
Young Eun JUNG ; Jeong Ho CHAE
Korean Journal of Psychopharmacology 2010;21(2):62-70
Resilience refers to a person's ability to successfully adapt to acute stress, trauma or more chronic forms of adversity, maintaining psychological well-being. Recent years have seen a lot of research into the neurobiological factors and mechanism that characterize resilient individuals. It has shown that resilience is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. Much more study is required to achieve a deeper understanding the genetic, biological, and psychological underpinnings of resilience, as well as the interactions between these factors.
Neurobiology
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Neurotransmitter Agents
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Phosphatidylethanolamines
2.Study on the change of pituitary- adrenocortical axis hormones and some neurotransmitters under the effect of Hegu acupuncture.
Journal of Vietnamese Medicine 2001;267(12):24-28
23 healthy male students from 19-26 of age were studied on the change of serum concentration of cortisol, ACTH, catecholamin, acetylchollin and beta-endorphin after 30 minutes Hegu electroacupuncture. The results show that: there is increase of catecholamin and acetylcholin concentration, decrease of cortisol concentration after exact Hegu electro- acupuncture.- No significant difference of ACTH and beta-endorphin concentration is detected before and after Hegu electro- acupuncture.- Above parameters do not change after outside the Hegu electro- acupuncture exept cortisol concentration that is markly lower.
Acupuncture
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hormones
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Neurotransmitter Agents
3.Distribution of the various neurotransmitter containing neurons in the rat olfactory bulb:an immunohistochemical analysis.
Jin Jeong KIM ; Jae Bong KIM ; Bong Seon KIM ; Sun Yong BAEK
Korean Journal of Anatomy 1993;26(4):361-376
No abstract available.
Animals
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Neurons*
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Neurotransmitter Agents*
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Rats*
4.Pain and Depression: A Neurobiological Perspective of Their Relationship.
Psychiatry Investigation 2015;12(1):1-8
Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.
Biological Factors
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Depression*
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Molecular Biology
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Neurotransmitter Agents
5.Post-Traumatic Growth: The Conception and Neurobiology.
Sang Won JEON ; Changsu HAN ; Joonho CHOI ; Jong Woo PAIK ; Chi Un PAE ; Jeong Ho CHAE
Korean Journal of Psychopharmacology 2015;26(1):1-9
Stress and trauma research has traditionally focused on negative sequelae of adversity. Recently, research has begun to focus on positive outcomes, specifically post-traumatic growth (PTG) - "positive change experienced as a result of the struggle with trauma" - which emphasizes the transformative potential of one's experiences with highly stressful events and circumstances. This article describes the concept of PTG at three different perspectives. In addition we reviewed the neurobiological factors and mechanism of PTG. It has shown that PTG is mediated by adaptive changes in several neural circuits involving numerous neurotransmitter and molecular pathways. Much more study is required to achieve a deeper understanding the biological and psychological underpinnings of PTG, as well as the interactions between these factors. After all, the clinical phenomenology of PTG is very important for mental growth after trauma. The findings of this article provide further directions for research and clinical implication of PTG.
Fertilization*
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Life Change Events
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Neurobiology*
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Neurotransmitter Agents
6.Acute Dystonia Following a Switch in Treatment from Atomoxetine to Low-dose Aripiprazole.
Omer BAŞAY ; Burge Kabukcu BASAY ; Onder ÖZTÜRK ; Zeki YÜNCÜ
Clinical Psychopharmacology and Neuroscience 2016;14(2):221-225
The present report describes the cases of a 17-year-old male patient and a 13-year-old female patient who developed acute dystonia following the administration of low-dose aripiprazole (5 mg/day) after the cessation of atomoxetine treatment. Although aripiprazole-induced dystonia has been previously reported in the literature, it is rare, and most of these cases were associated with doses higher than 5 mg/day. Furthermore, both of the patients in the present study discontinued atomoxetine prior to the initiation of aripiprazole treatment; thus, this report also discussed the possible mechanisms underlying the manifestation of dystonia from the perspective of neurotransmitter activity.
Adolescent
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Dystonia*
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Female
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Humans
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Male
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Neurotransmitter Agents
7.Aberrant Response of Selective Serotonin Reuptake Inhibitor in Two Patients with High N100 Amplitude Slope.
Seung Hwan LEE ; Jin Hwan KIM ; Jae Hyuk LEE ; Sangrae KIM ; Young Min PARK ; Sung Man BAE ; Jung Sook CHOO
Korean Journal of Psychopharmacology 2008;19(6):341-347
Serotonin is one of the most important neurotransmitters involved in the pathophysiology of depressive illness. The assessment of alteration of cerebral serotonin has been still controversial but interesting topic to study. Recently, increasing evidence has accumulated that the N100 amplitude slope reflects cerebral serotonin activity and treatment response of selective serotonin reuptake inhibitors (SSRIs). We report on two patients who showed abrupt mood changes and side effects after taking SSRI antidepressants. In both patients, aberrantly high N100 amplitude slopes were observed. Our cases suggest that the N100 amplitude slope may be a reliable indicator for predicting manic conversion and side effects in the SSRI treatment of depressive patients. Controlled studies are necessary to confirm whether a high N100 amplitude slope is a useful indicator of SSRI supersensitivity.
Antidepressive Agents
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Depression
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Humans
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Neurotransmitter Agents
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Serotonin
;
Serotonin Uptake Inhibitors
8.Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways.
Choongheon LEE ; Timothy A JONES
Journal of Audiology & Otology 2017;21(3):125-132
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that may act to enhance or inhibit the effect of the primary neurotransmitters [i.e., glutamate (Glu) and acetylcholine (ACh)] or alter their patterns of release. This review summarizes various efforts to identify drug targets including neurotransmitter and neuromodulator receptors in the vestibular sensory pathways. Identifying these receptor targets provides a strategic basis to use specific pharmacological tools to modify receptor function in the treatment and management of debilitating balance disorders. A review of the literature reveals that most investigations of the neuropharmacology of peripheral vestibular function have been performed using in vitro or ex vivo animal preparations rather than studying drug action on the normal intact vestibular system in situ. Such noninvasive approaches could aid the development of more accurate and effective intervention strategies for the treatment of dizziness and vertigo. The current review explores the major neuropharmacological targets for drug action in the vestibular system.
Acetylcholine
;
Animals
;
Dizziness
;
Glutamic Acid
;
In Vitro Techniques
;
Neuropharmacology
;
Neurotransmitter Agents
;
Receptors, Neurotransmitter
;
Vertigo
9.Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways.
Choongheon LEE ; Timothy A JONES
Journal of Audiology & Otology 2017;21(3):125-132
The use of pharmacological agents is often the preferred approach to the management of vestibular dysfunction. In the vestibular sensory pathways, the sensory neuroepithelia are thought to be influenced by a diverse number of neuroactive substances that may act to enhance or inhibit the effect of the primary neurotransmitters [i.e., glutamate (Glu) and acetylcholine (ACh)] or alter their patterns of release. This review summarizes various efforts to identify drug targets including neurotransmitter and neuromodulator receptors in the vestibular sensory pathways. Identifying these receptor targets provides a strategic basis to use specific pharmacological tools to modify receptor function in the treatment and management of debilitating balance disorders. A review of the literature reveals that most investigations of the neuropharmacology of peripheral vestibular function have been performed using in vitro or ex vivo animal preparations rather than studying drug action on the normal intact vestibular system in situ. Such noninvasive approaches could aid the development of more accurate and effective intervention strategies for the treatment of dizziness and vertigo. The current review explores the major neuropharmacological targets for drug action in the vestibular system.
Acetylcholine
;
Animals
;
Dizziness
;
Glutamic Acid
;
In Vitro Techniques
;
Neuropharmacology
;
Neurotransmitter Agents
;
Receptors, Neurotransmitter
;
Vertigo
10.Peptidergic Innervation of the Nasal Mucosa.
Journal of Rhinology 1997;4(1):5-12
Local release of neurotransmitters from autonomic nerve fibers in the nasal mucosa is known to play an important role for the protection of the lower airways. In addition to classical neurotransmitters, a diverse collection of neuropeptides are found in the sensory, parasympathetic, and sympathetic nerve fibers and may act as co-transmitters or modulators of effects induced by classical neurotransmitters. In the nasal mucosa, these neuropeptides are known to regulate the blood flow and content, secretory activity, and other epithelial functions and to be involved in the regulation of immunological reactions. There are increasing evidences that neuropeptides may play an important role in the pathophysiologic events in both specific and nonspecific hyperreactivity. Further study on the neuropeptides is needed to clarify the pathophysiologic mechanisms of nasal mucosal hyperreactivity.
Autonomic Pathways
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Nasal Mucosa*
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Nerve Fibers
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Neuropeptides
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Neurotransmitter Agents