No abstract available.
Neurotoxicity Syndromes* ; Solvents*

Humans ; Neurotoxicity Syndromes ; Paraquat ; toxicity

Humans ; Neurotoxicity Syndromes ; etiology ; Xylenes ; toxicity

Animals ; Biomarkers ; Hexanes ; poisoning ; toxicity ; Humans ; Neurotoxicity Syndromes ; etiology

Oculogyric crisis is an acute dystonia involving ocular muscles characterized by sustained conjugate upward or lateral deviation of the eyes. Metronidazole is a commonly used antimicrobial agent in treatment of anaerobic infections. However, its long-term use can cause toxic encephalopathy particularly in patients with hepatic dysfunction. Here, we describe a case of oculogyric crisis as a presenting manifestation of metronidazole-induced encephalopathy.
Brain Diseases ; Dystonia ; Humans ; Metronidazole ; Muscles ; Neurotoxicity Syndromes

BACKGROUD: It is generally acknowledged that a close relationship exists between chronic alcohol abuse and the occurrence of alcohol withdrawal seizure(AWS). About one third of AWS patients have been reported to be followed by delirium tremens (DT). OBJECTIVES: We assessed the factors that have influence on the development of DT in AWS patients. METHODS: We investigated clinical features and laboratory findings of 39 AWS patients who were admitted. The following factors were analyzed ; duration of alcohol intake, interval from last drinking to onset of AWS, interval from AWS to treatment, number of seizure, fever, laboratory findings (Mg, K, Na, Ca, P, respiratory alkalosis). RESULT: Fourteen patients developed DT(35.8%). There was fever in 36% of AWS patients with DT(5/14) and in 8% of AWS patients without DT(2/25). Number of seizure (p<.05) and interval from AWS to treatment(p<.01) showed statistically significant difference. But other factors were insignificant statistically. CONCLUSION: Our study suggests that number of seizure and interval from AWS to treatment seem to be significantly related to the development of DT in AWS patients.
Alcohol Withdrawal Delirium* ; Alcohol Withdrawal Seizures* ; Alcoholism ; Delirium* ; Drinking ; Fever ; Humans ; Risk Factors* ; Seizures ; Seizures, Febrile

Long-term occupational exposure to manganese might cause manganese poisoning, which would had adverse effects on nervous system of workers. The basal nucleus was damaged and dopaminergic neuron was injuried by manganese. The mechanism could be related with interfering the energy metabolism of central nerve, changing neurotransmitters, activating oxidation system and so on. Genetic factors may also plays a significant role in the neurotoxicity caused by manganese. Study the effects of manganese exposure biomarker, the neurotoxicity of biomarkers and the genetic susceptibility to early and susceptibility biomarkers will contribute to the prevention and control of manganese neurotoxicity.
Biomarkers ; Disease Susceptibility ; Humans ; Manganese ; Manganese Poisoning ; Neurotoxicity Syndromes ; Occupational Exposure

Adult ; Ethylene Dichlorides ; poisoning ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neurotoxicity Syndromes ; etiology ; pathology ; Young Adult

Antineoplastic Agents ; adverse effects ; Drug-Related Side Effects and Adverse Reactions ; therapy ; Humans ; Neurotoxicity Syndromes ; therapy

Drug Compounding ; Ivermectin ; analogs & derivatives ; toxicity ; Neurotoxicity Syndromes ; etiology ; therapy ; Pyridazines ; toxicity