1.Effects of neuropeptide Y on the motility of rabbit uterine strip.
Hee Sug RYU ; Kyung Eun LEE ; Young Soo AHN
Korean Journal of Obstetrics and Gynecology 1991;34(4):476-487
No abstract available.
Neuropeptide Y*
;
Neuropeptides*
2.Effects of acupuncture on leptin level and relative factors in the simple obesity Uigur patient.
Chinese Acupuncture & Moxibustion 2005;25(12):834-836
OBJECTIVETo observe effects of acupuncture on BMI, WHR and serum levels of leptin and neuropeptide Y in simple obesity Uigur patients to research the mechanism of acupuncture in slimming.
METHODSThirty simple obesity Uigur patients were treated with body acupuncture combined with electroacupuncture. Two courses later, their therapeutic effects were observed. And the above indexes were determined before and after treatment.
RESULTSThe clinical total effective rate was 80.00%, and BMI, WHR, and the serum leptin level decreased (P < 0. 001).
CONCLUSIONUigur patients of simple obesity possibly exist resistance of leptin and acupuncture can decrease the peripheral leptin content.
Acupuncture Therapy ; Electroacupuncture ; Humans ; Leptin ; blood ; Neuropeptide Y ; Obesity ; therapy
3.Distribution of Neuropeptides-Containing Neurons in the Superior Colliculus of the Cat Brain.
Wol Bong CHOI ; Moo Ho WON ; Mi A SON
Journal of the Korean Ophthalmological Society 1993;34(5):457-467
The distribution and morphology of cholecystokinin-8 (CCK 8)-, neuropeptide Y (NPY)-, Substance P (SP)- and vasoactive intestinal polypeptide (VIP)-immunoreactivity were examined in the cat superior colliculus (SC) by means of immunohistochemistry. Judging from this study, some neuropeptides-IR neurons may be present in the superficial layers of the sc. And these neurons and neuropeptides may be involved in the functions of the superficial layers.
Animals
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Brain*
;
Cats*
;
Immunohistochemistry
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Neurons*
;
Neuropeptide Y
;
Neuropeptides
;
Substance P
;
Superior Colliculi*
;
Vasoactive Intestinal Peptide
4.Effect of Negative Emotions on Serum Levels of Adrenocorticotropic Hormones and Neuropeptide Y in Hepatitis B Liver Cirrhosis Patients.
Fu-quan JIANG ; Xiao-lin XUE ; Tian-fang WANG ; Xiu-yan WU
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(10):1196-1199
OBJECTIVETo explore the effect of negative emotions on serum levels of adrenocorticotropic hormone (ACTH) and neuropeptide Y (NYP) in hepatitis B liver cirrhosis (HBLC) patients.
METHODSTotally 617 HBLC patients were assigned to the negative emotion group (415 cases) and the non-negative emotion group (202 cases) judged by negative emotions. Case numbers of various grading Child-Pugh were recorded in the two groups. Their liver functions were compared between the two groups. Serum levels of ACTH and NPY were detected using double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the two groups.
RESULTSThere was no statistical difference in Child-Pugh grading between the two groups (χ2 = 0.65, P = 0.72). Compared with the non-negative emotional group, serum ACTH levels decreased significantly in the negative emotion group with statistical difference (P < 0.05). There was no statistical difference in serum ACTH levels between the two groups (P > 0.05).
CONCLUSIONThe negative emotion of HBLC patients was not related to the serum ACTH level, but to relatively lower-concentration serum NPY levels.
Adrenocorticotropic Hormone ; blood ; Emotions ; Hepatitis B ; blood ; psychology ; Humans ; Liver Cirrhosis ; blood ; psychology ; Neuropeptide Y ; Serum
5.Expression of neuropeptide Y and long leptin receptor in gastrointestinal tract of giant panda.
Qihui LUO ; Xiuying TANG ; Zhengli CHEN ; Kaiyu WANG ; Chengdong WANG ; Desheng LI ; Caiwu LI
Chinese Journal of Biotechnology 2015;31(8):1175-1183
To study the expression and distribution of neuropeptide Y (NPY) and long leptin receptor (OB-Rb) in the gastrointestinal tract of giant panda, samples of three animals were collected from the key laboratory for reproduction and conservation genetics of endangered wildlife of Sichuan province, China conservation and research center for the giant panda. Paraffin sections of giant panda gastrointestinal tissue samples were observed using hematoxylin-eosin staining (HE) and strept actividin-biotin complex immunohistochemical staining (IHC). The results show that the intestinal histology of three pandas was normal and no pathological changes, and there were rich single-cell and multi-cell mucous glands, long intestinal villi and thick muscularis mucosa and muscle layer. Positive cells expressing NPY and OB-Rb were widely detected in the gastrointestinal tract by IHC methods. NPY positive nerve fibers and neuronal cell were widely distributed in submucosal plexus and myenteric plexus, especially in the former. They were arranged beaded or point-like shape. NPY positive cells were observed in the shape of ellipse and polygon and mainly located in the mucous layer and intestinal glands. OB-Rb positive cells were mainly distributed in the mucous layer and the laminae propria, especially the latter. These results confirmed that NPY and OB-Rb are widely distributed in the gut of the giant panda, which provide strong reference for the research between growth and development, digestion and absorption, and immune function.
Animals
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China
;
Intestines
;
metabolism
;
Neuropeptide Y
;
genetics
;
metabolism
;
Receptors, Leptin
;
genetics
;
metabolism
;
Ursidae
;
genetics
;
metabolism
6.Effect of acupuncture combined with medicine on neuropeptide Y in the patient of hypertension.
Yan-ling ZHANG ; Chuang-peng LI ; Min PENG ; Hui-shan YANG
Chinese Acupuncture & Moxibustion 2005;25(3):155-157
OBJECTIVETo search for a method for increasing therapeutic effect on hypertension and study on the mechanism.
METHODSSeventy-five cases were randomly divided into the treatment group (n=45) treated by acupuncture plus medicine, and the control group (n=30) treated by medicine. Their blood pressure and plasma neuropeptide Y (NPY) before and after treatment were investigated.
RESULTSBlood pressure and NPY content in both the two groups decreased significantly (P < 0.01), and the treatment group in decreasing blood pressure and NPY content was superior to the control group (P < 0.05).
CONCLUSIONAcupuncture and medicine have cooperation in treatment of hypertension, which is performed possibly through decreasing NPY.
Acupuncture Therapy ; Blood Pressure ; Blood Pressure Determination ; Humans ; Hypertension ; Neuropeptide Y ; blood
7.Type-dependent differential expression of neuropeptide Y in chicken hypothalamus (Gallus domesticus).
Gui-Qian CHEN ; Xiu-Fang HU ; Kunio SUGAHARA ; Ji-Shuang CHEN ; Xue-Mei SONG ; Hui-Chao ZHENG ; Yong-Qing JIANG ; Xin HUANG ; Jun-Fang JIANG ; Wei-Dong ZHOU
Journal of Zhejiang University. Science. B 2007;8(11):839-844
Neuropeptide Y (NPY) is one of the most important orexigenic agents in central regulation of feeding behavior, body weight and energy homeostasis in domestic chickens. To examine differences in the hypothalamic NPY between layer-type and meat-type of chickens, which are two divergent kinds of the domestic chickens in feeding behavior and body weight, we detected mRNA levels of NPY in hypothalamic infundibular nucleus (IN), paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) of these two types of chickens using one-step real time RT-PCR. The meat-type chicken had more food daily (about 1.7 folds) and greater body weights (about 1.5 folds) and brain weights than the layer-type chicken at the age of 14 d. In the meat-type of chicken, NPY mRNA levels of the IN and PVN were significantly greater than those of the LHA, and were not significantly different between the IN and PVN. However, in the layer-type of chicken, NPY mRNA levels were significantly greater in the IN than those in the LHA and PVN, and were not significantly different between the PVN and LHA. In all these hypothalamic regions, the layer-type of chicken had significantly higher NPY mRNA levels than the meat-type chicken did. These results suggest the expression of NPY in the hypothalamus has a type-dependent pattern in domestic chickens.
Animals
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Body Weight
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Chickens
;
classification
;
metabolism
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Hypothalamus
;
metabolism
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Male
;
Meat
;
Neuropeptide Y
;
genetics
;
RNA, Messenger
;
analysis
8.Correlation of Neuropeptide Y Neuron and its Size with Nitric Oxide Synthase in Cerebral Cortex of Aged Rats.
Sung Min KIM ; Young Bum KIM ; Won LEEM
Journal of the Korean Geriatrics Society 2000;4(4):278-285
No abstract available.
Aging
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Animals
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Cerebral Cortex*
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Neurons*
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Neuropeptide Y*
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Neuropeptides*
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Nitric Oxide Synthase*
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Nitric Oxide*
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Rats*
9.Effects on cervical spondylosis of vertebral artery type and the concentrations of plasma NPY and UII in the patients treated with the modified acupuncture at unilateral/bilateral Renying (ST 9).
Yanfu WANG ; Chaoyang MA ; Lingxiao LI ; Ting ZHANG ; Xinghua GUI ; Hao CHEN
Chinese Acupuncture & Moxibustion 2018;38(5):4733-4737
OBJECTIVETo observe the differences in the clinical therapeutic effects on cervical spondylosis of vertebral artery type (CSA) between the modified acupuncture and the routine acupuncture at unilateral/bilateral Renying (ST 9) as well as the impacts on the concentrations of plasma neuropeptide Y (NPY) and urotensinⅡ(UⅡ) in the patients.
METHODSA total of 160 patients were divided into a modified bilateral acupuncture group, a modified unilateral acupuncture group, a routine bilateral acupuncture group and a routine unilateral acupuncture group, 40 cases in each one according to the random number table. In the modified bilateral acupuncture group, the modified acupuncture was applied bilaterally to Renying (ST 9). In the modified unilateral acupuncture group, the modified acupuncture was applied unilaterally to Renying (ST 9). In the routine bilateral acupuncture group, the routine acupuncture was applied bilaterally to Renying (ST 9). In the routine unilateral acupuncture group, the routine acupuncture was applied unilaterally to Renying (ST 9). The treatment was given once every day, continuously for 6 days as one course. Two courses of treatment were required at the interval of 1 day. In each group, before and after treatment, we observed the peak systolic blood flow velocity (Vs) of the vertebral artery (VA) and the basilar artery (BA), cervical vertigo symptoms and functional assessment scales (ESCV) and the concentration of plasma NPY and UⅡ. The clinical therapeutic effects were compared among the groups.
RESULTSAfter treatment, the clinical therapeutic effect in the modified bilateral acupuncture group was 90.0% (36/40), which was better than 80.0% (32/40) in the modified unilateral acupuncture group, 77.5% (35/40) in the routine bilateral acupuncture group and 65.0% (26/40) in the routine unilateral acupuncture group (all <0.05). After treatment, Vs of VA and BA was improved remarkably in every group (all <0.01), and the result in the modified bilateral acupuncture group was higher than those in the other groups (all <0.01). After treatment, ESCV scores were all increased remarkably in every group (all <0.01). ESCV score and improvement index in the modified bilateral acupuncture group were all higher than those in the other groups (<0.05, <0.01). After treatment, the concentrations of plasma NPY and UⅡ were all reduced remarkably in every group (all <0.01) and the differences were significant among the groups (all <0.01).
CONCLUSIONThe modified bilateral acupuncture at Renying (ST 9) effectively regulates the blood supply of the vertebral basilar artery and improves the cerebral circulation. The effects are superior to those of the unilateral acupuncture at Renying (ST 9).
Acupuncture Points ; Acupuncture Therapy ; methods ; Humans ; Neuropeptide Y ; blood ; Spondylosis ; blood ; therapy ; Urotensins ; blood ; Vertebral Artery
10.Double Immunohistochemical Study on the Postnatal Development of Somatostatin - and Neuropeptide Y - Immunoreactive Neurons in Rat Cerebral Cortex.
Eun Young LEE ; Tae Soo LEE ; Sang Ho BAEK ; Jung Ik CHA
Korean Journal of Anatomy 1997;30(5):483-494
The postnatal development of somatostatin [SOM]- and neuropeptide Y[NPY]- immunoreactive[ir] neurons were examined in rat cerebral cortex considering their coexistence in cortical neurons. Using double immunohistochemical staining for SOM and NPY with diaminobenzidine and benzidine dihydrochloride as chromogens, we subdivided immunoreactive cells into double-labeled SOM/NPY-, SOM only-, and NPY only-ir neurons. Interestingly, SOM/NPY- and SOM only-ir neurons were detectable even at the day of birth, in contrast to NPY only-ir cells which first appeared in most cortices from two weeks of age. The morphological features of double-labeled SOM/NPY neurons were not identical to those SOM only- and NPY only-ir neurons. No apparent changes in the shape and size of single-labeled neurone occurred with age ; throughout their postnatal life they were round and ovoid, had a thin rim of perinuclear cytoplasm, and short processes. In contrast, the features of SOM/NPY-ir neurons were not consistent during postnatal life. By day P7, these neurons showed immature features ; they began to show more advanced neuronal characteristics by week P2, when they had a larger and more intensely-stained cytoplasm. In addition, their processes were longer, thicker and more complex than at earlier ages. At this age, SOM/NPY-ir somata were close to their maximum size. From week P4, they became smaller and were lightly labeled. SOM/NPY-ir somata were larger than SOM only- and NPY only-ir somata at and after two weeks of age. The present results showing different postnatal maturation patterns such as time of appearance and morphological features suggest that double-labeled SOM/NPY and single-labeled neurons might be different populations regulated by different mechanisms in their development, and with different functional properties during development.
Animals
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Cerebral Cortex*
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Cytoplasm
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Neurons*
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Neuropeptide Y*
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Neuropeptides*
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Parturition
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Rats*
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Somatostatin*