1.Cytotoxicity of gamma-ray in rat immature hippocampal neurons.
Miyoung YANG ; Myoung Sub SONG ; Sung Ho KIM ; Jong Choon KIM ; Joong Sun KIM ; Taekyun SHIN ; Changjong MOON
Journal of Veterinary Science 2011;12(3):203-207
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy gamma-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after gamma-irradiation. Radiation-induced cytotoxicity in immature hippocampal neurons increased in a dose-dependent manner. Pre-treatments of pro-apoptotic caspase inhibitors and anti-oxidative substances significantly blocked gamma-irradiation-induced cytotoxicity in immature hippocampal neurons. The results suggest that the caspase-dependent cytotoxicity of gamma-rays in immature hippocampal cultured neurons may be caused by oxidative stress.
Amifostine/pharmacology
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Animals
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Antioxidants/pharmacology
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Caspase 3/metabolism/radiation effects
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Catechin/analogs & derivatives/pharmacology
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Cell Survival/radiation effects
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Cells, Cultured/cytology/enzymology/*radiation effects
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Dose-Response Relationship, Radiation
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Female
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*Gamma Rays
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Hippocampus/cytology/enzymology/*radiation effects
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L-Lactate Dehydrogenase/radiation effects
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Neurons/cytology/enzymology/*radiation effects
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Poly(ADP-ribose) Polymerases/drug effects
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Pregnancy
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Rats
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Rats, Sprague-Dawley