1.Relationship between Cavum Septum Pellucidum and Epilepsy.
Ki Young CHOI ; Jong Pil EUN ; Ha Young CHOI
Journal of Korean Neurosurgical Society 2004;36(1):13-17
OBJECTIVE: The authors study a relationship between the presence of cavum septum pellucidum(CSP) and the development of epilepsy by comparing the presence of CSP, which has been known to be a normal variation, in normal control group and epilepsy patients. METHODS: This study included 377 patients with epilepsy and 252 controls without epilepsy. Of epilepsy patients, 168 patients underwent surgery due to intractability and 209 patients was on medication of antiepileptic drugs. Control group had only headache and no visible lesion in MRI. Of 168 surgical patients, 102 patients had temporal lobe epilepsy and 66 patients had extratemporal lobe epilepsy. Ninty five patients showed a neuronal migration disorder in histopathologic findings. Definition of "CSP" and "partial CSP" was followed by Pauling's classification. RESULTS: CSP was present 8.2% of epilepsy patients and 1.6% of control group(p<0.01). CSP was detected in 11.3% of patients with surgical treatment and in 5.7% of patients with medical treatment. CSP was noticed in 8.9% of temporal lobe epilepsy, in 15.2% of extratemporal lobe epilepsy, in 13.7% of patients with neuronal migration disorder, and in 8.2% of patients with no neuronal migration disorder. CONCLUSION: Presence of CSP is statistically higher in epilepsy patients than in control group. This results indicates that the presence of CSP may not be a simple normal variation, and it can be considered a developmental anomaly that may contribute to epileptogenesis.
Anticonvulsants
;
Classification
;
Epilepsy*
;
Epilepsy, Temporal Lobe
;
Headache
;
Humans
;
Magnetic Resonance Imaging
;
Neuronal Migration Disorders
;
Septum Pellucidum*
2.A Study of Ulegyria as Pathognomonic Aspects of Congenital Bilateral Perisylvian Syndrome.
Han Woong KIM ; Kyu Yong CHO ; Min Cheol LEE ; Hyung Ihl KIM ; Young Jong WOO ; Myeong Kyu KIM
Journal of Korean Neurosurgical Society 2005;37(2):124-128
OBJECTIVE: Congenital bilateral perisylvian syndrome (CBPS) has been defined as a characteristic malformative perisylvian polymicrogyria (PMG) in patients with clinical symptoms of pseudobulbar palsy and epileptic seizures. For the present study, we investigate clinicopathologic features of CBPS associated with timing of lesion formation. METHODS: Clinicopathologic features of CBPS from 6 patients with surgical resection of the cerebral lesions due to medically intractable seizures were studied. RESULTS: Seizure onset ranged from 1 to 10years (average 6.7years) of age, and average duration of seizure was 23years. All had complex partial seizures, and two patients had additional tonic clonic seizures. Magnetic resonance (MR) images showed polymicrogyria, atropic gyri with gliosis. In the histopathologic examination, the cortical lesions revealed features of ulegyria ; atrophic and sclerotic gyri, laminar loss of neurons, extensive lobular gliosis throughout the gray and white matter, neuronoglial nodule formation, and many amyloid bodies. Unlayered or four-layered PMG was not identified. CONCLUSION: Above data suggest that CBPS might be caused by ulegyria resulting from developmental cortical defect during early fetal stage or acquired hypoxic/ischemic injury in prenatal or postnatal life.
Amyloid
;
Epilepsy
;
Gliosis
;
Humans
;
Malformations of Cortical Development
;
Neuronal Migration Disorders
;
Neurons
;
Pseudobulbar Palsy
;
Seizures
3.A Case of Neuronal Heterotopia.
Jeong Hae JOO ; Eun Joo SEOK ; Min Jeong KIM ; Son Sang SEO
Journal of the Korean Pediatric Society 1997;40(8):1173-1177
Neuronal migrational disorders of the brain represent abnormalities in the formation of the neocortex caused by faulty migration of the subependymal neuroblasts. The neuroblasts normally migrate between the sixth and 15th gestational week and in doing so form the six-layered neocortex. When the migration does not occur in a normal fashion the resultant brain anomalies include lissencephaly, pachygyria, schizencephaly, hemimegalencephaly, heterotopia, and polymicrogyria. Neuronal heterotopia is a collection of nerve cells in abnormal locations as a result of arrest of their radial migration, improper formation, or destruction of the radial glial fiber. We reported a case of neuronal heterotopia with brief review of related literatures.
Agenesis of Corpus Callosum
;
Brain
;
Lissencephaly
;
Malformations of Cortical Development
;
Neocortex
;
Neuronal Migration Disorders
;
Neurons*
4.Neurofilament Protein Subtype Expression in Neuronal Migration Disorders.
Hyun Sik OH ; Yoo Duk CHOI ; Hyun Joong KIM ; Kyung Hwa LEE ; Myoung Kyu KIM ; Young Jong WOO ; Jae Hyu KIM ; Min Cheol LEE
Korean Journal of Pathology 2003;37(6):413-420
BACKGROUND: Neuronal migration disorder (NMD) is one of the causes of medically intractable epilepsy. As neurosurgical treatments for medically intractable epilepsy have expanded recently, precise histopathologic diagnosis is required. Histopathologic grading of NMD is important due to its association with neocortical development and expectation of prognosis. Many studies revealed abnormalities of neuronal cytoskeletal protein in abnormal neuronal cells of NMD. METHODS: We performed immunohistochemical staining for neurofilament protein (NF) subtypes, one of the neuronal cytoskeletal proteins, and investigated the staining pattern of specific cells in each grade of NMD. RESULTS: NF-L was more intensely labeled in perikarya, dendrites, and axons of normal or small sized dysplastic neurons, cytomegalic neurons, and balloon cells than of normal-looking neurons. Furthermore, positive reaction was more intense in high-grade lesion. NF-H and NF-M were mainly positive in the axons of gray and white matter and weakly positive in a few cytomegalic neurons and some balloon cells. CONCLUSION: NF-L is a better marker than NF-H and NF-M for the detection of normal or small sized dysplastic neurons, cytomegalic neurons, and balloon cells and for grading of NMD.
Axons
;
Cerebral Cortex
;
Cytoskeletal Proteins
;
Dendrites
;
Diagnosis
;
Epilepsy
;
Nervous System Malformations
;
Neurofilament Proteins
;
Neuronal Migration Disorders*
;
Neurons*
;
Prognosis
5.Preliminary Result of Epilepsy Surgery in Patients with Neuronal Migration Disorder.
Sung Kyun HWANG ; Chun Kee CHUNG ; Chang Wan OH ; Sang Keon LEE ; Je G CHI ; Hyun Jib KIM ; Dae Hee HAN
Journal of Korean Neurosurgical Society 1996;25(3):627-634
Neuronal migration disorders (NMD's) are a rare group of developmental structural lesions characterized by disorganization of cortical architecture with aberrant columnar and laminar arrangement, often causing intractable seizures. During September 1994 to February 1995, we operated on six patients with NMD to treat intractable seizures, Male female ratio of these 6 patients was 2:4 and mean age at seizure onset was 14 years old(range 6-28 years), indicating early onset of epilepsy. Mean age at seizure surgery was 29 years old(range 23-41 years), and mean follow-up duration after operation was 4 months(range 3-6 months). In their past medical history, three patients had experienced febrile seizure at pediatric age, and one of them had a history of anoxic damage during delivery. Following preoperative localization, the lesion was removed completely in five patients. In the other one patient part of the lesion was located the speech and motor area, leading to partial removal. On histologic examination, two of them showed cortical dysplasia and the other four revealed microdysgenesis. During follow-up for six months, five patients were free of seizure and in the other one patient, whose lesion was removed incompletely, the frequency of seizure decreased by 95%.
Epilepsy*
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Malformations of Cortical Development
;
Neuronal Migration Disorders*
;
Neurons*
;
Seizures
;
Seizures, Febrile
6.Effects of Ethosuximide on the Pilocarpine Induced Seizure in Rat Model of Neuronal Migration Disorder.
Byung Kon KIM ; In Sun CHOI ; Jin Hwa CHO ; Il Sung JANG ; Maan Gee LEE ; Byung Ju CHOI
The Korean Journal of Physiology and Pharmacology 2006;10(5):235-242
Cortical malformation-associated epileptic seizures are resistant to conventional anticonvulsant drugs. Relatively little research has been conducted on the effects of antiepileptic drugs (AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of ethosuximide (ETX) in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injected control animals. Field potential recordings were used to monitor the amplitude and number of population spikes, and paired pulse inhibition in response to stimulation of the commissural pathway. Pharmaco-resistance was tested by measuring seizure latencies after pilocarpine administration (320 mg/kg, i.p.) with and without pre-treatment with ETX. Pre-treatment with 300 mg of ETX significantly prolonged the latency to the status epilepticus (SE) in both control and MAM-treated groups. Pre-treatment with ETX 100mg and ETX 200 mg had little effect in MAM-exposed rats. However, ETX 200 mg prolonged the latency to the SE in control groups. Spontaneous field potential and secondary after-discharges were higher for MAM-treated rat in comparison with control rats injects with ETX. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard ETX assessed in vivo. These data suggest that ETX do not prolong seizure latencies in MAM-rats exposed to pilocarpine.
Animals
;
Anticonvulsants
;
Brain
;
Epilepsy
;
Ethosuximide*
;
Methylazoxymethanol Acetate
;
Models, Animal*
;
Neuronal Migration Disorders*
;
Neurons*
;
Pilocarpine*
;
Rats*
;
Seizures*
;
Status Epilepticus
7.Brain Magnetic Resonance Imaging Findings in Children with Cerebral Palsy: Compared between Preterm and Term Groups.
Chang Hyun YOO ; Dae Young YOON ; Hyun Sang CHO ; Ki Sik MIN ; Jong Wan KIM ; Ki Yang RYOO
Journal of the Korean Child Neurology Society 1999;6(2):332-339
PURPOSE: We used MRI to retrospectively analyze the brain of patients suffering from cerebral palsy. Our aim is to determine MRI's role in the assessment of brain damage, the relationship of gestational age. METHODS: A total of 66 patients (29 preterm group and 37 term group), who visited Kang-Dong Sacred Heart Hospital from January, 1994 to July, 1998, were enrolled in this study. RESULTS: Among the 29 in the preterm group, 13 patients showed MR images of hypoxic ischemic injury in which periventricular leukomalacia (PVL) and multifocal ischemic necrosis in 12 (41.3%) and 1 (3.4%) respectively. Neuronal migration disorders were 6 (20.8%), other congenital malformations 5 (17%) and normal MR images 5 (17%) in this preterm group. Among the 37 in the term group, 22 patients showed MR images of hypoxic ischemic injury in which selective neuronal necrosis were 11 (29.7%), PVL 4 (10.8%), focal and multifocal ischemic necrosis 4 (10.8%) and status marmoratus 3 (8.1%). Neuronal migration disorders were 4 (10.8%), other congenital malformations 5 (13.5%) and normal MR images 6 (16.2%) in the term group. CONCLUSION: MRI provided useful information in a majority of children with cerebral palsy. Hypoxic ischemic injury was significantly different in preterm and term groups. PVL was frequent in the preterm group and selective neuronal necrosis was statistically common in the term group.
Brain*
;
Cerebral Palsy*
;
Child*
;
Gestational Age
;
Heart
;
Humans
;
Infant, Newborn
;
Leukomalacia, Periventricular
;
Magnetic Resonance Imaging*
;
Movement Disorders
;
Necrosis
;
Neuronal Migration Disorders
;
Neurons
;
Retrospective Studies
8.Brain Magnetic Resonance Imaging Findings in Children withCerebral Palsy: Compared between Preterm and Term Groups.
Hang Hyun YOO ; Dae Young YOON ; Hyun Sang CHO ; Ki Sik MIN ; Jong Wan KIM ; Ki Yang RYOO
Journal of the Korean Child Neurology Society 1999;6(2):322-331
PURPOSE: We used MRI to retrospectively analyze the brain of patients suffering from cerebral palsy. Our aim is to determine MRI's role in the assessment of brain damage, the relationship of gestational age. METHODS: A total of 66 patients(29 preform group and 37 term group), who visited Kang-Dong Sacred Heart Hospital from January, 1994 to July, 1998, were enrolled in this study. RESULTS: Among the 29 in the preform group, 13 patients showed MR images of hypoxic ischemic injury in which periventricular leukomalacid(PVL) and multifocal ischemic necrosis in 12(41.3%) and 1(3.4%) respectively. Neuronal migration disorders were 6(20.8%), other congenital malformations 5(17%) and normal MR images 5(17%) in this preform group. Among the 37 in the term group, 22 patients showed MR images of hypoxic ischemic injury in which selective neuronal necrosis were 11(29.7%), PVL 4(10.8%), focal and multifocal ischemic necrosis 4(10.8%) and status marmoratus 3(8.1%). Neuronal migration disorders were 4(10.8%), other congenital malformations 5(13.5%) and normal MR images 6(16.2%) in the term group. CONCLUSION: MRI provided useful information in a majority of children with cerebral palsy. Hypoxic ischemic injury was significantly different in preform and term groups. PVL was frequent in the preterm group and selective neuronal necrosis was statistically common in the term group.
Brain*
;
Cerebral Palsy
;
Child*
;
Gestational Age
;
Heart
;
Humans
;
Magnetic Resonance Imaging*
;
Movement Disorders
;
Necrosis
;
Neuronal Migration Disorders
;
Neurons
;
Paralysis*
;
Retrospective Studies
9.Surgery of Intractable Epilepsy Associated with Cortical Dysplasia.
Journal of Korean Neurosurgical Society 1999;28(7):942-948
Cortical dysplasia(CD) is recently known as a cause of intractable partial epilepsies that are amenable to surgical treatment. The development of new neuroimaging has facilitated the recognition of these neuronal migration disorders. Here we examine some clinical features that permit early suspicion of focal cortical dysplasia and better surgical results. From a consecutive surgical series of 239 patients with intractable epilepsy since 1992, pathologically verified 31 CD including 6 CD with dysembryoplastic neuroepithelial tumor(DNT) were selected for this study. The location and extent of resection were determined by both epileptogenic zones and the structural lesion, according to presurgical evaluation(neuroimaging, EEG, intracranial recording), intraoperative electrocorticography(ECoG) and functional brain mapping. The series consisted of 21 men and 10 women with ages at seizure onset ranging from 1 to 26 years(mean 11.1year). The duration of the epilepsy prior to surgery ranged from 3 to 30 years(mean 14.3). The CD was verified in 17(11.1%) of 153 cases with temporal lobe epilepsy and 8(16.6%) of 48 cases with extratemporal epilepsy, mainly peri-Rolandic area. The lesion location of CD with DNT were temporal(4 cases) and extratemporal(2 cases). The histology of the surgical specimens showed cortical dyslamination in 26 patients, additional dysplastic neurons in 2 patients, and additional balloon cells in 3 patients. Excellent and good clinical results were achieved in 29 cases. CD should be suspected when intractable partial epilepsy occur in children. Careful investigation of neuroimaging techniques with high resolution MRI and sophisticated presurgical and intraoperative tailoring is essential for better outcome with identification of CD.
Brain Mapping
;
Child
;
Electroencephalography
;
Epilepsies, Partial
;
Epilepsy*
;
Epilepsy, Temporal Lobe
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Malformations of Cortical Development*
;
Neuroimaging
;
Neuronal Migration Disorders
;
Neurons
;
Seizures
10.Bilateral Frontal Polymicrogyria: An Autopsy Case Report.
Yi Kyeong CHUN ; Jong Sun CHOI ; Je G CHI
Korean Journal of Pathology 2011;45(Suppl 1):S62-S65
Bilateral frontal polymicrogyria is a recently recognized syndrome characterized by symmetric polymicrogyria of both frontal lobes that presents with delayed motor and language development, spastic quadriparesis, and variable mental retardation. However, the postmortem findings of this syndrome are not fully elaborated. Here we describe an autopsy case of bilateral frontal polymicrogyria in a male fetus delivered at 22 weeks gestation due to extensive chorioamnionitis. The microscopic findings included a thinned cortical plate with fair neuronal maturation. There were no signs of neuronal damage and the white matter was unremarkable.
Autopsy
;
Chorioamnionitis
;
European Continental Ancestry Group
;
Female
;
Fetus
;
Frontal Lobe
;
Humans
;
Intellectual Disability
;
Language Development
;
Male
;
Malformations of Cortical Development
;
Muscle Spasticity
;
Neuronal Migration Disorders
;
Neurons
;
Pregnancy
;
Quadriplegia