1.Simultaneous cochlear implantation and translabyrinthine removal of vestibular schwannoma in type 2 neurofibromatosis caused by a deletion of 22q12.1-q12.2 including NF2 gene.
Qiu Jing ZHANG ; Guo Jian WANG ; Wei Dong SHEN ; Meng Di HONG ; Fen XIONG ; Qiu Ju WANG ; Dong Yi HAN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2021;56(11):1199-1204
2.Treatment research progress on the treatment of neurofibromatosis type 2-associated vestibular schwannoma.
Yingchao ZHAO ; Qin YANG ; Yao JIANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(10):955-958
Neurofibromatosis type 2 (NF2) is a dominantly inherited genetic condition. Bilateral vestibular schwannoma, which are benign tumors, composed of neoplastic Schwann cells that arise from the eighth cranial nerve, are the hallmark of NF2. Standard approaches for treatment of growing vestibular schwannoma include observation, surgical removal and radiation therapy. Molecular targeted therapies also present great prosperity in recent years. In this review, we summarize the latest progresses on the treatment of NF2-associated vestibular schwannoma.
Humans
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Molecular Targeted Therapy
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Neurofibromatosis 2
;
radiotherapy
;
surgery
;
therapy
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Neuroma, Acoustic
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radiotherapy
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surgery
;
therapy
3.Surgical management of type II orbital neurofibromatosis.
Ming LIN ; Jin LI ; Hui-fang ZHOU ; Yao FU ; Xian-Qun FAN
Chinese Journal of Plastic Surgery 2008;24(5):347-349
OBJECTIVETo study the clinical manifestations and surgical treatment of Type II orbital neurofibromatosis.
METHODSFrom Jan, 2001, to Oct, 2006, clinical data of 16 cases with type II orbital neurofibromatosis were retrospectively analyzed in the Department of Ophthalmology, Ninth People's Hospital, Medical School of Shanghai Jiao Tong University.
RESULTSAll patients had orbito-temporal or intra-orbital neurofibromatosis, combined with periorbital deformities. After partial tumor resection, the orbital reconstruction and blepharoplasty were performed in the same stage. The patients were followed up for 6-12 months with no relapse. The vision was improved in 6 cases and kept the same in 10 cases. The cosmetic results were satisfactory in all cases. 5 cases were re-operated because of relapse of blepharoptosis.
CONCLUSIONSThe function and appearance can be markedly improved after one-stage partial tumor resection, orbital reconstruction and blepharoplasty in patients with type II orbital neurofibromatosis.
Adolescent ; Adult ; Female ; Follow-Up Studies ; Humans ; Male ; Neurofibromatosis 2 ; surgery ; Orbital Neoplasms ; surgery ; Reconstructive Surgical Procedures ; methods ; Retrospective Studies ; Young Adult
4.Neurofibromatosis type 2 and auditory brainstem implantation.
Hong-jun XIAO ; Dennis K K AU ; Hui YAU ; Chun-kuen CHOW ; Yiu-wah FAN ; William Ignace WEI
Chinese Medical Journal 2007;120(16):1456-1459
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