We experience a case of plexiform neurofibroma in a 10-year-old girl who had unusual giant pigmentation and multiple skcletal abnormalities including pectus cariimtum. Histologic examination of the lesion taken from right upper arm permitted a diagnosis of plexiform neurofibroma.
Arm ; Child ; Diagnosis ; Female ; Humans ; Neurofibroma, Plexiform* ; Pigmentation*

We experience a case of plexiform neurofibroma in a 10-year-old girl who had unusual giant pigmentation and multiple skcletal abnormalities including pectus cariimtum. Histologic examination of the lesion taken from right upper arm permitted a diagnosis of plexiform neurofibroma.
Arm ; Child ; Diagnosis ; Female ; Humans ; Neurofibroma, Plexiform* ; Pigmentation*

Fat containing masses, except mediastinal lipomatosis, of the thorax are uncommon. In spite of uncommonoccurences, as CT can detect not only the fat content but also the presence and character of the non-fattycomponent of the mass, accurate preoperative diagnosis can usually be made in most cases of fat containingmediastinal masses. Authors report 6 cases of fat containing mediastinal masses, that were diagnosedpreoperatively by CT scan, comprising 2 cases of limpoma(combined with plexiform neurofibroma in a case), 1liposarcoma, 1 thymolipoma, and 2 cases of omental hernia through Morgagni foramen.
Diagnosis ; Hernia ; Lipomatosis ; Neurofibroma, Plexiform ; Thorax ; Tomography, X-Ray Computed

Neurogenic neoplasms of the facial nerve are uncommon. These neoplasms are usually classified into two types: schwannoma and neurofibroma. Although intraparotid facial nerve schwannomas have been documented sporadically throughout the medical literature, neurofibromas from intraparotid facial nerve are extremely rare. Neurogenic neoplasms of the intraparotid facial nerve are usually diagnosed intraoperatively by tissue biopsy. The management of neurogenic tumors associated with normal facial function is a particularly difficult problem. These benign tumors of neurogenic origin should be considered in the differential diagnosis of parotid masses. This is a case report of a solitary neurofibroma involving the main trunk of the facial nerve in the parotid gland.
Biopsy ; Diagnosis, Differential ; Facial Nerve* ; Neurilemmoma ; Neurofibroma* ; Parotid Gland

Nerve sheath tumors are not frequent in the head and neck area. They might arise from large or small units of cranial, cervical and brachial plexuses as well as the cervical symphatic nerves. Their clinical course and findings are not similar, and preoperative diagnosis are extremely difficult in some cases. We experiencd eighteen cases of extracranial nerve sheath tumors in the head and neck regions during the past six years Twelve of them were schwannomas, and six of them were neurofibromas which did not associate with Von Recklinghausen's diseases. This analysis of eighteen cases and two representative cases are reported with literature review.
Brachial Plexus ; Diagnosis ; Head* ; Neck* ; Nerve Sheath Neoplasms* ; Neurilemmoma ; Neurofibroma

BACKGROUNDNeurofibroma is a kind of benign neoplasm that derives from nervous tissues. Though this tumor is the most common types in the peripheral nervous system, it is rarely seen in the choroid and easy to be misdiagnosed of choroidal melanoma. The aim of this study was to review the clinical features of neurofibroma of the choroid in the Chinese race.

METHODSA retrospective case series design was used. Two male and one female patients diagnosed with choroidal neurofibroma in Beijing Tongren Eye Center were included in this study. The clinical histories were abstracted from the patients' medical records. Routine eye examinations including visual acuity, intraocular pressure, slit lamp and ophthalmoscope were performed. Auxiliary examinations included fluorescein fundus angiography (FFA), AB-ultrasound scan, color doppler imaging (CDI), and magnetic resonance imaging (MRI). Local resection of the tumors was performed and the specimens underwent pathological examinations.

RESULTSThe tumors were of yellow-pink color with pigmentation on the surface. CDI showed arterial blood signals in the tumor and MRI showed high-intensity in the T1-weighted image and a slightly increased intensity in the T2-weighted image. FFA and indocyaninegreen angiography demonstrated the tumors were of hypofluorescence at early stage and hyperfluorescence with prominent leakage at late stage. The pathological examination confirmed the tumors were choroidal neurofibroma. After 5 - 10-year follow-up, there were no recurrences of the tumors and the retinas were well attached.

CONCLUSIONSChoroidal neurofibroma is difficult to be diagnosed clinically and pathological confirmation is important. These tumors can be managed conservatively by local resection.

Adult ; Choroid Neoplasms ; diagnosis ; surgery ; Female ; Humans ; Male ; Middle Aged ; Neurofibroma ; diagnosis ; surgery ; Retrospective Studies

35 neurogenic tumors of the thorax were analyzed with plain film and CT scan. Radiological analysis emphasizedshape, location calcification, bone change, pleural change in plain film and calcification, cystic change, bonechange, pleural change, presence of contrast enhancement in CT scan. The results were as follows; 1. Age may bethe most important clinical factor for differential diagnosis. 2. Plain film findings(35 cases); 1) The mostcommon shape in the ganglion series tumor (ganglioneuroma, ganglioneuroblastoma, neuroblastoma), was elongation(80%) and these tumors generally had tapered borders(50%). In contrast with those of the genglion series, nervesheath tumors(schwannoma, neurofibroma, malignant Schwannoma) showed a definite tendency to be roudn (95%) and thesulcus effect was more frequetnly seen(67.5%). Most of the masses were smooth. The lobulated masses were commonlymalignant ganglion series tumors. 2) Though overall incidence of calcification was low(8.6%), it was observed morefrequently in ganglion series tumors(20%). 3) Associated bony abnormality were generally observed in large tumorsabove 5cm in long axis, especially in neuroblastoma and ganglioneuroblastoma. 4) Tumors showed pleural effusionwere all malignant. 3. CT findings (17 cases); 1) The overall incidence of cystic change of the mass was 23.6%. Itwas most common in Schwannoma(60%). 2) The contrast enhancement was noted in 64.7%. It's degree was variable andshowed no predilection to any specific tumors. 3) The incidence of calcification, associated bony abnormality andpleural effusion were similiar to plain film. Confident specific diagnosis can be made in most of the neurogenictumors of the thorax by shape of the mass in plain film and internal architecture in CT combined with patient'sage as clinical information.
Diagnosis ; Diagnosis, Differential ; Ganglion Cysts ; Ganglioneuroblastoma ; Incidence ; Neuroblastoma ; Neurofibroma ; Thorax ; Tomography, X-Ray Computed

A neurofibroma of the gastrointestinal tract is frequently associated with type 1 neurofibromatosis. A solitary neurofibroma, which refers to a localized neurofibroma occurring in patients without stigmata of neurofibromatosis, can rarely occur in the stomach. The majority of neurofibromas of the stomach remain small and asymptomatic, and are usually found incidentally. Surgical resection is required for symptomatic relief and for confirmation of the diagnosis. Herein, the case of a 68-year-old woman found to have a solitary neurofibroma in the angle of stomach is reported. The patient underwent a laparoscopy assisted distal gastrectomy, with a gastroduodenostomy. The gross, microscopic and immunohistochemical findings were consistent with the diagnosis of a neurofibroma of the stomach.
Aged ; Christianity ; Diagnosis ; Female ; Gastrectomy ; Gastrointestinal Tract ; Humans ; Laparoscopy ; Neurofibroma* ; Neurofibromatoses ; Neurofibromatosis 1 ; Stomach*

Twenty-three patients with mass in parotid gland were examined with magnetic resonance (MR) imaging. The confirmed diagnoses were pleomorphic adenoma (9 cases), primary malignant tumor (3 cases), vascular malformation (3 cases), post operative scar (3 cases), parotid glandular lymphadenopathy (2 cases), lipoma (1 case), neurofibroma (1 cases), and chronic organizing abscess (1 case). Pleomorphic adenomas appeared as well-marginated lobulating masses with multi-compartment by internal fibrous septa. Most pleomorphic adenomas showed low signal intensity on T1-weighted images, and high signal intensity on T2-weighted images. Malignant tumors showed slightly high signal intensity on T2-weighted images but were less intense in signal intensity compared with that of benign tumors. One case of chronic abscess showed MR signal intensity similar to the malignant tumor. The lesions were clearly delineated on pre-contrast T1-weighted images in all cases. Gd-DTPA enhancement was helpful in characterizing the nature of the mass, but had limited diagnostic value in delineating the lesion from the surrounding normal tissue.
Abscess ; Adenoma, Pleomorphic ; Cicatrix ; Diagnosis ; Gadolinium DTPA ; Humans ; Lipoma ; Lymphatic Diseases ; Neurofibroma ; Parotid Gland ; Vascular Malformations

Lacrimal sac tumors are relatively rare and epithelial origin, mostly. The clinical menifestations of lacrimal sac tumors include epiphora, chronic dacrtocystitis, or lacrimal mass. Primary neurofibroma of lacrimal sac is benign nature and malignant transformation is rare. But malignant lacrimal sac tumors can be life-threatening; Therefore, the early diagnosis and treatment are important. We reported an experience of a 37-year-old female who had epiphora, pruritis, lacrimal mass, and facial asymmetry. The patient was finally diagnosed with pigmented neurofibroma of lacrimal sac that was proven by dacryocystogram, CT scan, and histophthologic finding.
Adult ; Early Diagnosis ; Facial Asymmetry ; Female ; Humans ; Lacrimal Apparatus Diseases ; Neurofibroma* ; Pruritus ; Tomography, X-Ray Computed