No abstract available.
Neural Tube Defects* ; Neural Tube* ; Prenatal Diagnosis*

No abstract available.
Neural Tube Defects*

We report the case of a 33-week-old female fetus born with craniorachischisis to a gravida 5, para 4 (3104) mother with no previous history of conceiving a child with a neural tube defect. Craniorachischisis is characterized by anencephaly and an open defect extending from the brain to the spine and is the most severe and fatal type of neural tube defect. Although the cause of neural tube defects is hypothesized to be multifactorial and is usually sporadic, the risk is increased in neonates born to mothers with a family history or a previous pregnancy with neural tube defect, both of which are not present in the index case. This case is unique in that only during the fifth pregnancy did the couple conceive a child with a neural tube defect, emphasizing that folic acid supplementation, the sole preventive measure proven to decrease the risk of neural tube defects, remains to be important in the periconceptual period for all women of childbearing age.
Autopsy ; Congenital Abnormalities ; Neural Tube Defects ; Neural Tube Defects

No abstract available.
Neural Tube Defects* ; Spinal Canal*

No abstract available.
Child ; Humans ; Neural Tube Defects

A sex determination method has been developed using the polymerase chain reaction (PCR) which involved the amplification of sex determining region Y (SRY) gene and the amplification of the HLA-DQ gene as an internal control, in the one PCR reaction using two sex of the primers. The PCR products were sort ADN of 139 bp for SRY and 239/242 bp for HLA-DQ region spectively. The amplification of this method in prenatal diagnosis to prevent genetic diseases, in forensic science.
Fetus ; Neural Tube Defects ; Aneuploidy

In this study, serum samples collected from 48 high-risk pregnant women were screened for three markers: alpha-feto protein (AFP), beta-human chorionic gonadotropin (b-HCG) and conjugated estriol (UE3) to define the risk of congenital aneuploidy and neural tube defect...The result showed the serum AFP level raised in two cases (more than 2.5MoM - Multiple of Median). One case has decrease in AFP (less than 0.06MoM) combined with decrease in UE3. Once has decrease in AFP (less than 0.06mOM) combined with increase in b-HCG. One case has decrease in AFP (less than 0.06MoM) combined with decrease in UE3 and increase in b-HCG level. One case has decrease in AFP alone (less than 0.06MoM). Fetal neural tube defect was identified in one case. Other four cases have increase in b-HCG only. these pregnancies should be referred to genetic study and further tests.
Fetus ; Neural Tube Defects ; Aneuploidy

A case of neurenteric cyst within the cervical canal is reported. He has been suffered from gradual aggravated quardriparesis since 4 months. On spine C-T scan and cervical myelographic examination, intradural extramedullary mass was detected. And so total laminectomy of C4, C5 and C6 was performed. We could diagnose by the pathological findings.
Laminectomy ; Neural Tube Defects* ; Spinal Canal* ; Spine

To clarify the prognostic factors influencing clinical outcome, the authors retrospectively analyzed 50 cases of thoracolumbar vertebral junction fracture treated at our hospital between September 1989 and October 1992. The age of the patients ranged from 23 to 75 years(median 49 years) and the male-to-female ratio was 33:17. Falling was the major mode of injury(m=27). The kyphotic angle between fractured vertebrae and the ratio of neural canal encroachment was measured in a simple X-ray and a computed tomography(CT) of the thoracic spine. An ANOVA test was performed to evaluate the predicting factors to determine the final outcome. The kyphotic angle and loss of height of vertebral body were not significantly correlated with the neurological status of the patients. However, the ratio of the compromised area of the neural canal was closely correlated with the neurological outcome(p value<0.05). The worst prognosis was found in patients with fracture-dislocation. In conclusion, it is suggested that early surgical intervention must be considered in the neurologically compromised patients whose CT demonstrates neural canal encroachment by bony fragments.
Humans ; Neural Tube ; Prognosis ; Retrospective Studies ; Spine

To clarify the prognostic factors influencing clinical outcome, the authors retrospectively analyzed 50 cases of thoracolumbar vertebral junction fracture treated at our hospital between September 1989 and October 1992. The age of the patients ranged from 23 to 75 years(median 49 years) and the male-to-female ratio was 33:17. Falling was the major mode of injury(m=27). The kyphotic angle between fractured vertebrae and the ratio of neural canal encroachment was measured in a simple X-ray and a computed tomography(CT) of the thoracic spine. An ANOVA test was performed to evaluate the predicting factors to determine the final outcome. The kyphotic angle and loss of height of vertebral body were not significantly correlated with the neurological status of the patients. However, the ratio of the compromised area of the neural canal was closely correlated with the neurological outcome(p value<0.05). The worst prognosis was found in patients with fracture-dislocation. In conclusion, it is suggested that early surgical intervention must be considered in the neurologically compromised patients whose CT demonstrates neural canal encroachment by bony fragments.
Humans ; Neural Tube ; Prognosis ; Retrospective Studies ; Spine