1.Chemoprevention of Mammary, Cervix and Nervous system Carcinogenesis in Animals using Cultured Panax ginseng Drugs and Preliminary Clinical Trials in Patients with Precancerous Lesions of the Esophagus and Endometrium.
Vladimir G BESPALOV ; Valeriy A ALEXANDROV ; Andrey Y LIMARENKO ; Boris O VOYTENKOV ; Valeriy B OKULOV ; Mels K KABULOV ; Alexander P PERESUNKO ; Larisa I SLEPYAN ; Viktor V DAVYDOV
Journal of Korean Medical Science 2001;16(Suppl):S42-S53
The anticarcinogenic effects and mechanisms of the biotechnological drugs of Panax ginseng C.A. Meyer cultivated in Russia, bioginseng, panaxel and panaxel- 5, were studied. Bioginseng was produced from a tissue culture of ginseng root cultured on standard medium, whereas panaxel and panaxel-5 were produced from ginseng tissue root cultures using standard mediums enriched with 2-carboxyethylgermanium sesquioxide and 1-hydroxygermatran-monohydrate respectively. All three ginseng drugs inhibited the development of mammary tumors induced by intramammary injections of N-methyl-N-nitrosourea (MNU) in rats, the development of the brain and spinal cord tumors induced by transplacental administration of N-ethyl-N-nitrosourea (ENU) in rats, and the development of uterine, cervical and vaginal tumors induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene (DMBA) in mice. The ginseng drugs induced the cytotoxic activity of macrophages in mice, enhanced T-lymphocyte rosette formation in guinea pigs exposed to cyclophosphamide, and stimulated the production of thyroid hormones in rats. These mechanisms may contribute to the anticarcinogenic action of the ginseng drugs. The organic germanium compounds present in panaxel and panaxel-5 did not potentiate the anticarcinogenic or immuno- stimulatory effects as much as biogeinseng. Preliminary clinical trials with panaxel and bioginseng were carried out in patients with precancerous lesions of the esophagus and endometrium. Panaxel was found to have a strong therapeutic effect in patients suffering from chronic erosive esophagitis. Bioginseng induced the regression of adenomatous-cystic hyperplasia of the endometrium in some patients. Thus, we conclude that the drugs of ginseng appear to hold considerable promise for future cancer chemoprevention.
Adenocarcinoma/chemically induced/prevention & control
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Adult
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Animal
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Antineoplastic Agents, Phytogenic/*therapeutic use
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Cells, Cultured
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Cervix Neoplasms/chemically induced/prevention & control
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Clinical Trials
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Cytotoxicity Tests, Immunologic
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Disease Models, Animal
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Endometrial Neoplasms/pathology/prevention & control
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Endometrium/pathology
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Esophageal Neoplasms/pathology/prevention & control
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Esophagus/pathology
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Estradiol/blood
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Female
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Fibroadenoma/chemically induced/prevention & control
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Human
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Macrophages, Peritoneal/cytology/immunology
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Male
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Mammary Neoplasms, Experimental/chemically induced/prevention & control
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Mice
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Mice, Inbred C57BL
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Neoplasms, Experimental/chemically induced/*prevention & control
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Nervous System Neoplasms/chemically induced/prevention & control
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Panax/*metabolism
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Precancerous Conditions/pathology/*prevention & control
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Rats
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Tissue Culture
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Uterine Neoplasms/chemically induced/prevention & control
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Vaginal Neoplasms/chemically induced/prevention & control
2.Clinical study of Jiawei Huangqi Guizhi Wuwu Decoction in preventing and treating peripheral neuro-sensory toxicity caused by oxaliplatin.
Yuan LI ; Hui-juan CUI ; Jin-chang HUANG ; Xiao-qin WU
Chinese journal of integrative medicine 2006;12(1):19-23
OBJECTIVETo evaluate the efficacy of Jiawei Huangqi Guizhi Wuwu Decoction (JHGWD) in treating neuro-sensory toxicity induced by oxaliplatin.
METHODSA randomized controlled self-crossover trial was performed. Thirty-one patients were randomly divided into AB and BA groups. Patients in A cycle belonged to the treated group, who were treated with chemotherapy combined with oxaliplatin plus JHGWD. Patients in B cycle belonged to the control group and were treated with chemotherapy alone. The peripheral neuro-sensory toxicity was observed and analyzed.
RESULTSThe main neurotoxicity was cold-induced paresthesia after the use of oxaliplatin, which included hyperaesthesia, chill, anaesthesia in the extremities, electrified sensation, formication, foreign body sensation and pain that might be exacerbated by exposure to cold. Twenty patients (64.5%) suffered from neuro-sensory toxicity in the treated group and 27 cases (87.1%) in the control group. Symptoms were more serious and lasted longer in the control group than those in the treated group (P < 0.01).
CONCLUSIONJHGWD could prevent and reduce the occurrence and intensity of acute peripheral neuro-sensory toxicity caused by oxaliplatin.
Adult ; Aged ; Antineoplastic Agents ; adverse effects ; therapeutic use ; Cross-Over Studies ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Gastrointestinal Neoplasms ; drug therapy ; Humans ; Male ; Middle Aged ; Organoplatinum Compounds ; adverse effects ; therapeutic use ; Paresthesia ; chemically induced ; drug therapy ; prevention & control ; Peripheral Nervous System Diseases ; chemically induced ; drug therapy ; prevention & control ; Phytotherapy