2.Cerebral venous thrombosis in an adult patient with nephrotic syndrome.
Luhua WEI ; Yang LIU ; Yining HUANG
Chinese Medical Journal 2014;127(18):3354-3355
3.Sympathetic nervous system level and ambulatory blood pressure in children with primary nephrotic syndrome.
Zhiquan XU ; Zhuwen YI ; Xiqiang DANG ; Xiaochuan WU ; Yan CAO ; Danlin HUANG ; Shuanghong MO ; Xiaojie HE
Journal of Central South University(Medical Sciences) 2010;35(7):693-698
OBJECTIVE:
To explore the change in ambulatory blood pressure monitoring (ABPM) value and the sympathetic nervous system (SNS) level in children with primary nephrotic syndrome(PNS) and their relationship.
METHODS:
ABPM and casual blood pressure(CBP) were tested in 114 children with PNS and 12 normal children as a control group. The 24-h urine noradrenaline(NA), adrenaline(A) and dopamine(DA) content were detected through high-performance liquid chromatography with electrochemical luminescence and the correlation with ABP was analyzed.
RESULTS:
Among 114 children with PNS, 101 had elevated blood pressure (88.6%), 45 showed high incidence of masked hypertension (39.5%), and 80 non-dipper blood pressure (70.2%). Systolic blood pressure level and blood pressure load were greater than diastolic blood pressure. NA, A, and DA levels of the PNS group were significantly higher than those of the control group, while those of the elevated blood pressure group were significantly higher than those of the normal blood pressure group in PNS children. SNS levels were positively correlated with blood pressure levels and blood pressure load, and negatively correlated with night BP decreasing rates.
CONCLUSION
Children with PNS have high incidence of hypertension with large proportion of masked hypertension and non-dipper blood pressure. Severe masked hypertension classification should be set up. In PNS children, SNS activity is elevated that might evaluate the blood pressure level and decrease blood pressure circadian rhythm.
Adolescent
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Blood Pressure
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physiology
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Blood Pressure Monitoring, Ambulatory
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Case-Control Studies
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Child
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Child, Preschool
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Female
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Humans
;
Hypertension
;
diagnosis
;
etiology
;
Male
;
Nephrotic Syndrome
;
complications
;
physiopathology
;
Sympathetic Nervous System
;
physiopathology
4.A case of Tsutsugamushi disease presenting with nephrotic syndrome.
Ju Hyun LEE ; Mi Jung LEE ; Dong Ho SHIN ; Shin Wook KANG ; Kyu Hun CHOI ; Tae Hyun YOO
The Korean Journal of Internal Medicine 2013;28(6):728-731
Nephrotic syndrome associated with Tsutsugamushi disease has not been previously reported. We are describing a case of Tsutsugamuchi disease presenting with nephrotic syndrome. A 72-year-old woman presented with fever and generalized edema. Laboratory studies revealed a leukocytosis, hypoalbuminemia, and hypercholesterolemia. Her urine protein excretion was 5.4 g/day. The anti-Tsutsugamushi antibody test was strongly positive (1:2,560). A renal biopsy was performed, and pathologic findings revealed membranous glomerulonephritis. The patient's clinical symptoms improved markedly after treatment with doxycycline.
Aged
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Anti-Bacterial Agents/therapeutic use
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Antibodies, Bacterial/blood
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Biopsy
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Doxycycline/therapeutic use
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Female
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Glomerulonephritis, Membranous/diagnosis/*etiology
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Humans
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Nephrotic Syndrome/diagnosis/*etiology
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Orientia tsutsugamushi/immunology
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Scrub Typhus/*complications/diagnosis/drug therapy/microbiology
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Treatment Outcome
5.Idiopathic collapsing glomerulopathy in children: report of two cases.
Ren-gui WEI ; Shu-mei CHEN ; Tang JIANG ; Xiao-yun JIANG ; Yu ZENG ; Ying MO
Chinese Journal of Pediatrics 2004;42(10):731-733
OBJECTIVEIdiopathic collapsing glomerulopathy (ICG) is a clinically and pathologically distinct variant of focal segmental glomerulosclerosis, which is characterized by proteinuria (often nephrotic range) and rapid progression to end-stage renal failure. The typical pathological changes are global/segmental glomerular collapse, hypertrophy and hyperplasia of podocytes and severe tubulointerstitial lesions. Most ICG patients who have been reported in previous published papers are adults. ICG in children is rare. The study aimed to analyze and investigate clinical manifestations, renal histopathological findings, treatment and outcomes of ICG in children.
METHODSData of two cases of ICG, a 7-year-old boy and a 12-year-old girl, were analyzed. Both of them were Chinese and Han. Clinical characteristics, results of laboratory tests, renal histopathological findings, treatment, outcomes and prognosis of the two children with ICG were retrospectively analyzed. Results were compared with published data.
RESULTSThese two children presented typical clinical features of nephrotic syndrome. The quantity of 24 hr urine protein was 7.6 g/d (0.47 g/kg x d for boy) and 10.67 g/d (0.35 g/kg x d for girl). Both of them had hypertension (blood pressure ranged from 130/90 to 150/110 mmHg) and hypercholesterolemia (15.4 mmol/L for the boy and 11.3 mmol/L for the girl). The serum albumin was 12 g/L for girl and 23 g/L for boy. The creatinine clearance rate gradually decreased from normal range to 30 ml/min for the girl. The histopathological changes in renal biopsy of them were focal segmental or global glomerular collapse, hypertrophy and hyperplasia of podocytes and severe tubulointerstitial lesions. These two cases were steroid-resistant and were treated with pulse intravenous methylprednisolone and pulse intravenous cyclphosphamade in one case, who rapidly progressed to end-stage renal failure and died half a year later. Another one was treated with cyclosporine. He showed continuous hypertention and heavy proteinuria for eight months.
CONCLUSIONICG in the 2 children was a severe disease which presented steroid-resistant nephrotic syndrome and rapidly progressive renal failure. The pathological characteristics was global/segmental glomerular collapse, hypertrophy and hyperplasia of podocytes and severe tubulointerstitial lesions. In children with ICG treatment was difficult and the prognosis was poor.
Child ; Disease Progression ; Female ; Glomerulosclerosis, Focal Segmental ; complications ; diagnosis ; pathology ; therapy ; Glucosinolates ; Humans ; Kidney ; pathology ; Kidney Failure, Chronic ; etiology ; Kidney Glomerulus ; pathology ; Male ; Nephrotic Syndrome ; etiology ; Proteinuria ; etiology ; Treatment Outcome
6.A case report: congenital syphilis-induced multiple organ dysfunction.
Chinese Journal of Pediatrics 2014;52(3):229-230
Biomarkers
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analysis
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Delayed Diagnosis
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Diagnosis, Differential
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Female
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Humans
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Infant, Newborn
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Liver Diseases
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diagnosis
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drug therapy
;
etiology
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Liver Function Tests
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Nephrotic Syndrome
;
diagnosis
;
drug therapy
;
etiology
;
Penicillin G
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administration & dosage
;
therapeutic use
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Skin Diseases
;
diagnosis
;
drug therapy
;
etiology
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Syphilis, Congenital
;
complications
;
diagnosis
;
drug therapy