Although congenital renal tumors are rare, congenital mesoblastic nephroma (CMN) is the most common renal tumor in early infancy. It is non-metastatic, well differentiated, amenable to surgical removal, and carries a good prognosis. Polyhydramnios has been detected in most of the published cases of CMN. However, we experienced a rare case of fetal CMN associated with oligohydramnios. A 28-yr old woman at 34 weeks of gestation was referred to our hospital for oligohydramnios and a fetal abdominal mass. An ultrasonography revealed a huge, well-encapsulated mass arising from the right kidney. An emergency cesarean section was performed due to fetal distress. After birth, despite intensive neonatal care, the baby died because of renal failure, disseminated intravascular coagulopathy, pulmonary edema, together with other problems.
Pregnancy ; Oligohydramnios/*diagnosis/therapy ; Nephroma, Mesoblastic/*diagnosis/therapy ; Kidney Neoplasms/*diagnosis/therapy ; Infant, Newborn ; Humans ; Fetal Diseases/etiology/prevention & control ; Female ; Fatal Outcome ; Cesarean Section ; Adult

Congenital mesoblastic nephroma is a rare renal tumor that is diagnosed during pregnancy and is associated with polyhydramnios, prematurity, and neonatal hypertension. Differential diagnoses include Wilms tumor, adrenal neuroblastoma, and other abdominal tumors. We report a case of congenital mesoblastic nephroma detected by prenatal ultrasonography as a large fetal renal mass with polyhydramnios at 32 weeks of gestation. Ultrasonography showed a 6x6-cm complex, solid, hyperechoic, round mass in the right kidney. At 35 weeks of gestation, the patient was admitted with preterm premature rupture of membranes and the baby was delivered vaginally. Postnatal ultrasonography and computed tomography showed a heterogeneous solid mass on the right kidney. At the end of the first week of life, a right nephrectomy was performed and subsequent pathological examination confirmed a cellular variant of congenital mesoblastic nephroma with a high mitotic count. Postoperative adjuvant chemotherapy was administered. The newborn was discharged in good condition.
Chemotherapy, Adjuvant ; Diagnosis, Differential ; Drug Therapy ; Humans ; Hypertension ; Infant, Newborn ; Kidney ; Membranes ; Nephrectomy ; Nephroma, Mesoblastic* ; Neuroblastoma ; Polyhydramnios ; Pregnancy ; Prenatal Diagnosis* ; Rupture ; Ultrasonography ; Ultrasonography, Prenatal ; Wilms Tumor

Recently, with the advent of prenatal ultrasonography, renal tumors in the neonatal period are diagnosed with increasing frequency. Detected most solid masses in the neonatal kidney will mostly be proven to be a congenital mesoblastic nephroma but a Wilms' tumor in the neonate is quite uncommon. We found a solid mass in the fetal left kidney at 39th week of gestation by prenatal ultrasonography. The infant, a healthy male in external appearance was delivered by Cesarean section at 40th week of gestation. At one day of age, we confirmed a left renal mass with ultrasonography and this neonate underwent left nephrectomy at nine days of age. The tumor was pathologically diagnosed as stage 1 with favorable histology of Wilms' tumor. Chemotherapy was performed postoperatively according to the EE-regimen of National Wilms' Tumor Studies (NWTS)-4 for 24 weeks. Now the patients is in good condition with no recurrence after postoperative 17 months.
Cesarean Section ; Drug Therapy ; Female ; Humans ; Infant ; Infant, Newborn* ; Kidney ; Male ; Nephrectomy ; Nephroma, Mesoblastic ; Pregnancy ; Prenatal Diagnosis ; Recurrence ; Ultrasonography ; Ultrasonography, Prenatal* ; Wilms Tumor*

The congenital mesoblastic nephroma is the most common renal neoplasm seen in the first few months of life. This tumor usually benign, but local recurrences and metastases have been reported, and treatment is total nephrectomy. This entity must be differentiated from Wilm's tumor so as to avoid unnecessary postoperative irradiation and chemotherapy. Recently, we experienced a case of congenital mesoblastic nephroma in female newborn infant. Diagnosis was made with physical examination, plain roentgenogram of the abdomen, ultrasonography of the abdomen and I.V.P. and confirmed with microscopic examination. A brief review of the related literature was made on this subject.
Abdomen ; Diagnosis ; Drug Therapy ; Female ; Humans ; Infant, Newborn ; Kidney Neoplasms ; Neoplasm Metastasis ; Nephrectomy ; Nephroma, Mesoblastic* ; Physical Examination ; Recurrence ; Ultrasonography ; Wilms Tumor

The congenital mesoblastic nephroma is the most common renal neoplasm seen in the first few months of life. This tumor usually benign, but local recurrences and metastases have been reported, and treatment is total nephrectomy. This entity must be differentiated from Wilm's tumor so as to avoid unnecessary postoperative irradiation and chemotherapy. Recently, we experienced a case of congenital mesoblastic nephroma in female newborn infant. Diagnosis was made with physical examination, plain roentgenogram of the abdomen, ultrasonography of the abdomen and I.V.P. and confirmed with microscopic examination. A brief review of the related literature was made on this subject.
Abdomen ; Diagnosis ; Drug Therapy ; Female ; Humans ; Infant, Newborn ; Kidney Neoplasms ; Neoplasm Metastasis ; Nephrectomy ; Nephroma, Mesoblastic* ; Physical Examination ; Recurrence ; Ultrasonography ; Wilms Tumor