Matrix Metalloproteinases ; Neovascularization, Pathologic ; Neovascularization, Physiologic

Humans ; Microvessels ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Plaque, Atherosclerotic ; pathology

Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Neovascularization, Physiologic ; Osteogenesis

Cells, Cultured ; Humans ; Neovascularization, Physiologic ; immunology ; Pericytes ; metabolism ; physiology

Endothelial colony-forming cells (ECFCs), different from classical endothelial progenitor cells, are late endothelial progenitor cells with the capability to promote angiogenesis. Recent studies showed that ECFCs have a huge angiogenesis potential in the restoration of ischemic hearts, lungs or brains. They are also able to induce the expression of vascular related factor to promote angiogenesis in repair of limb ischemia or bone injury. Furthermore, ECFCs possess a strong homing effect for tumor, which is closely related to tumor occurrence, development and prognosis. Thus, ECFCs are a novel direction for vascular regeneration study, and may lead to ground-breaking progresses in fields of tissue regeneration and tumor.
Endothelial Cells ; cytology ; Humans ; Ischemia ; Neovascularization, Physiologic ; Stem Cells ; cytology

Collagen ; Drug Combinations ; Flow Cytometry ; methods ; Humans ; Laminin ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Proteoglycans

Angiogenin, as a member of the ribonuclease superfamily, is an angiogenic protein. The angiogenic ability of angiogenin plays an important role in many physical and pathological processes. Angiogenin can induce endothelial cell migration, proliferation, tubulation, as well as inhibition of cellular apoptosis. Angiogenin can be used to modulate the angiogenetic process of tissue engineered constructions via local delivery. Furthermore, angiogenin can also be regarded as a biomarker for diagnostic evaluation of malignancy, or as a target for cancer therapy. This paper presents a comprehensive overview of the angiogenic mechanisms of angiogenin, as well as its potential application in the process of wound healing and treatment of ischemic diseases and malignancy.
Cell Movement ; Humans ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Ribonuclease, Pancreatic ; therapeutic use

Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels though sprouting or other ways. It plays an important role in both physiological and pathological processes. Researches have found that platelets may contribute to angiogenesis as well. In this paper, we review the role of platelet in angiogenesis, especially the relationship with tumor angiogenesis, and discuss clinical implications of these findings.
Blood Platelets ; physiology ; Humans ; Neoplasms ; blood supply ; Neovascularization, Pathologic ; physiopathology ; Neovascularization, Physiologic ; physiology ; Vascular Endothelial Growth Factor A ; physiology

Mesenchymal stem cells (MSC) have the potential of multi-directional differentiation, and can recruit endothelial cells, promote their proliferation, migration and angiogenesis, improve blood perfusion and oxygen suppliment, and repair damaged tissue. Exosome secreted by MSC contain mother cell-specific proteins, lipids and nucleic acids, and acts as signaling molecule, playing an important role in cell communication, thereby altering target cell function. In this review, the biological characteristics of MSC and its exosome, the mechanism of promoting vascular regeneration in patients with ischemic diseases, and the mechanism of hypoxia-inducible factor-1α（HIF-1α） in the vascular ischemia of ischemic diseases are all summarized briefly.
Cell Differentiation ; Exosomes ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Mesenchymal Stem Cells ; Neovascularization, Pathologic ; Neovascularization, Physiologic

Rapid angiogenesis is one of the major issues in the field of tissue engineering, and it is an urgent problem to be solved. The process and related mechanism of angiogenesis have been deeply researched. Meanwhile, various methods or strategies for promoting angiogenesis, involving the application of stem cells and growth factors, and construction and modification of biomaterial scaffolds, have also been reported. On one hand, many remarkable advances in the field of promoting angiogenesis have been achieved; on the other hand, the complexity of mechanism and regulation of angiogenesis have gradually been recognized and emphasized. This paper presents a comprehensive overview of advances in research of the strategies for promoting angiogenesis in the field of tissue engineering.
Animals ; Biocompatible Materials ; Humans ; Neovascularization, Physiologic ; Stem Cells ; Tissue Engineering ; Tissue Scaffolds