Cluster of differentiation 147(CD147)/extracellular matrix metalloproteinase inducer (EMMPRIN) is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells. A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells. CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al. This review focuses on the structural and biological characteristics of CD147 as well as recent advances in its multiple functions in malignant tumours and underlining mechanisms.
Basigin ; metabolism ; Fibroblasts ; Humans ; Neoplasms ; metabolism ; Neovascularization, Pathologic

The occurrence and development of many tumors all relate with abnormal expression of the Notch receptor. The role of different Notch receptors may be different, even contrary in different tissues at different stages of tumor development, as well as in the same system tumors. Notch signaling pathway plays an important role in cell proliferation, differentiation, apoptosis and tumor angiogenesis, and is as a meeting point for many important cell signaling pathway. Angiogenesis is regulated by complex interactions of multiple activators and inhibitors. Vascular endothelial growth factor (VEGF) and Notch signaling pathway are involved in such process. Many studies have confirmed that Notch signaling pathway plays a key role in the embryonic development and tumour angiogenesis. Recent studies have also revealed that Notch signaling pathway has many potential drug targets. Based on study of Notch signaling pathway and its molecular mechanism of leukemia, to design drugs effecting these targets to block and activate Notch signaling pathway for therapy of leukemia and angiogenesis diseases has a broad application prospects. This review summarises the components of Notch signaling pathway and the role of Notch signaling pathway in occurrence of leukemia and angiogenesis.
Animals ; Humans ; Leukemia ; metabolism ; pathology ; Neovascularization, Pathologic ; metabolism ; pathology ; Receptors, Notch ; metabolism ; Signal Transduction

The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on.
Chemokine CXCL12 ; metabolism ; physiology ; Humans ; Leukemia ; metabolism ; Neovascularization, Pathologic ; Receptors, CXCR4 ; metabolism ; physiology

Animals ; Humans ; Hypoxia ; metabolism ; Hypoxia-Inducible Factor 1 ; genetics ; metabolism ; Neovascularization, Pathologic ; metabolism

OBJECTIVETo study the expression of vascular endothelial growth factor (VEGF) and transcription factor E26 transformation-specific-1 (ETS-1) in breast carcinoma and its effect on angiogenesis, tumor invasion and metastasis.

METHODSIn situ hybridization and immunohistochemistry (streptomycin avidin-biotin-peroxidase complex, SP) were used to detect the mRNA and protein expression of VEGF and ETS-1 in breast carcinoma.

RESULTSVEGF mRNA and its protein were highly expressed in tumor cells of breast carcinoma. The positive rate was 75% (36/48) and 70.8% (34/48) respectively. There was almost no expression of VEGF in vascular endothelial cells. Over expression of ETS-1 was seen in both breast carcinoma and endothelial cells. The positive rate of ETS-1 mRNA and protein in carcinoma cells was 85.4% (41/48) and 79.2% (38/48) respectively. The microvessel density was significantly higher in VEGF and ETS-1 highly expressed groups than that in the low expressed groups (P < 0.01). Both VEGF and ETS-1 expressions were well correlated with the histological grade and lymph node metastasis.

CONCLUSIONSVEGF and ETS-1 can promote angiogenesis in breast carcinoma and correlate with tumor invasion and lymph node metastasis. The expression of VEGF and ETS-1 might be considered to be a reference indicator for determining the angiogenesis and invasion of breast carcinoma.

Breast Neoplasms ; Humans ; In Situ Hybridization ; Lymphatic Metastasis ; Neovascularization, Pathologic ; metabolism ; Vascular Endothelial Growth Factor A ; metabolism

Special emphasis about cancer metastasis was concentrated on tumor cells themselves, and we usually considered the ability of migration and invasion was the final decider. Recently, bewaring of tumor microenvironment is a fundamental determinant in metastasis has become the most outstanding breakthrough. Considerable "microbes" in the microenvironment are closely linked with tumor metastatic behaviors, and the major proportion of them is tumor-associated macrophages (TAMs). Actually, TAMs conserve immediate "cross-talk" with cancer cells throughout tumor development. It is generally accepted that TAMs have mostly pro-tumoral functions and play an important role in several stages of tumor progression. This progression involves a series of events that leads from the primary site to the metastatic site, including tumor cell growth, angiogenesis, migration, invasion, intravasation and finally extravasation at distant site where the process begins again (metastasis). Thereby, TAMs has attracted substantial attentions in recent years and could become a promising therapeutic strategy. In this review, we focus on the multi-functions of TAMs in cancer and certain drugs targeting TAMs for cancer treatment those are under experimental research procedures or have even been entered human clinical tests.
Animals ; Gene Expression Regulation, Neoplastic ; Humans ; Macrophages ; metabolism ; Neoplasms ; pathology ; Neovascularization, Pathologic ; metabolism ; pathology

OBJECTIVETo observe the expression of vascular endothelial growth factor(VEGF)in deep second-degree scald wounds,with an attempt to further explore the role of VEGF in burn wound healing.

METHODSTotally 36 adult Wistar rats were randomized into two groups: the scald group(30 rats)and the control group(6 rats). In the scald group,rat models of deep second-degree scald wounds were established. Full-thickness tissues of the wounds were collected respectively 1,3,7,14,and 21 days after the modeling. The expressions of the VEGF mRNA and protein were detected with real-time quantitative PCR and Western blot,respectively. In the control group,the same procedures were performed but without modeling.

RESULTSCompared with the control group,the expressions of VEGF mRNA and proteins were significantly higher in the scald group(P<0.05). The expression levels reached the peak on day 1,gradually decreased on day 3,reached the lowest points on day 14,but increased again on day 21.

CONCLUSIONSVEGF is involved in the healing of scald burns. The expression of VEGF during the wound healing is closely correlated with the wound angiogenesis.

Animals ; Burns ; metabolism ; Neovascularization, Pathologic ; Rats ; Rats, Wistar ; Vascular Endothelial Growth Factor A ; metabolism ; Wound Healing ; physiology

OBJECTIVE: To study the expression of vascular endothelial growth factor(VEGF) and microvessel density (MVD), in nasal polyps and its significance. METHOD: The expression of VEGF, in nasal polyps from 50 patients and inferior turbinates from 10 patients were studied with immunohistochemical methods, measuring their grey score, the relations between expression microvessel density were analyzed. RESULT: (1) The differences between the VEGF expression in nasal polyp gland and vascular were significant (P < 0.05). (2) The differences between the microvessel quantities in nasal polyps and inferior turbinates were significant (P < 0.05). (3) The association between VEGF expression in vascular of nasal polyps and microvessel density was significant (r = -0.664 (< 0. 05). CONCLUSION In nasal polyps, VEGF, expression increased. Those results show that the abnormal expression of VEGF and MVD may play an impotent role in the development of nasal polyps. There was an important value for proper treatment and prediction of nasal polyps.
Humans ; Microvessels ; pathology ; Nasal Polyps ; metabolism ; pathology ; Neovascularization, Pathologic ; Vascular Endothelial Growth Factor A ; metabolism

Humans ; Phosphorylation ; Serine/metabolism* ; Protein Serine-Threonine Kinases/metabolism* ; Signal Transduction ; Neovascularization, Pathologic

Anemia ; metabolism ; physiopathology ; Animals ; Cell Hypoxia ; Genetic Therapy ; Humans ; Hypoxia-Inducible Factor 1 ; genetics ; metabolism ; physiology ; Neovascularization, Pathologic ; metabolism ; pathology ; Neovascularization, Physiologic ; Osteogenesis ; RNA, Messenger ; metabolism