1.Roles of MicroRNAs in cancer stem cells.
Ting-ting ZHANG ; Chao-hui LU ; Jie CHEN
Acta Academiae Medicinae Sinicae 2012;34(2):174-177
Cancer stem cells are cells with stem cell characteristics within a tumor. With increased proliferative capabilities, they are able to self-renew and develop into various cell types, and thus play important roles in the formation, development, metastasis, and recurrence of tumors. MicroRNAs are a class of endogenous, small non-protein coding RNA molecules. Through regulating the expression of genes depending on the complementation between the microRNAs and their targets, microRNAs play important roles in various human cancers. This article summarizes recent research advances in the roles of microRNAs in cancer stem cells.
Humans
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MicroRNAs
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Neoplastic Stem Cells
3.Characterization of tumorspheres generated from nasopharyngeal carcinoma cell line, TW06 and chemoresistance to docetaxel and oxaliplatin
Iris Goh Wen Li ; Yip Wai Kien ; Seow Heng Fong
Malaysian Journal of Medicine and Health Sciences 2015;11(2):9-20
In this study, tumorspheres were generated from TW06 nasopharyngeal carcinoma cell line and
examined their expression of putative cancer stem-like cell surface markers and drug sensitivity. The
rate of tumorsphere expansion from dissociated late passage TW06 tumorspheres (≥ passage 15) was
higher than that from parental cells and dissociated 10-day-old (passage 0) tumorspheres. The expression
of CD24 surface marker was lost in the generation of tumorspheres and the loss was reversible after
differentiating the tumorspheres in monolayer culture conditions. Drug sensitivity assay showed that late
passage tumorspheres were resistant to docetaxel and oxaliplatin treatment. Our data suggest that serially
passaged tumorspheres possess the characteristics of CSCs that render them a suitable preclinical in
vitro model for evaluating anticancer drug efficacy and elucidating the underlying mechanisms of drug
resistance.
Neoplastic Stem Cells
;
Nasopharyngeal carcinoma
4.Application of Nanotechnology in Targeting of Cancer Stem Cells: A Review
Fatemeh ASGHARI ; Rahele KHADEMI ; Faezeh Esmaeili RANJBAR ; Ziba Veisi MALEKSHAHI ; Reza Faridi MAJIDI
International Journal of Stem Cells 2019;12(2):227-239
Cancer is increasingly apparent as a systems-level, network happening. The central tendency of malignant alteration can be described as a two-phase procedure, where an initial increase of network plasticity is followed by reducing plasticity at late stages of tumor improvement. Cancer stem cells (CSCs) are cancer cells that take characteristics associated with normal stem cells. Cancer therapy has been based on the concept that most of the cancer cells have a similar ability to separate metastasise and kill the host. In this review, we addressed the use of nanotechnology in the treatment of cancer stem cells.
Nanostructures
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Nanotechnology
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Neoplasm Metastasis
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Neoplastic Stem Cells
;
Plastics
;
Stem Cells
8.The most promising strategy targeted against cancer stem cells.
Zhi-xiong LIN ; Li-juan YANG ; Shi-ming ZHEN
Chinese Medical Journal 2011;124(24):4303-4303
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