1.Cathepsin S in pathogenesis of neurological diseases.
Da-Ming WANG ; Jian-Ren LIU ; Hao-Yu HU ; Guo-Ping SHI
Journal of Zhejiang University. Medical sciences 2008;37(4):422-426
Cathepsin S, one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. Those functions are closely associated with the pathogenesis of various neurological diseases. It would be beneficial to elucidate the role of Cathepsin S in the pathogenesis of various neurological diseases.
Alzheimer Disease
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physiopathology
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Astrocytoma
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physiopathology
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Brain Neoplasms
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physiopathology
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Cathepsins
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physiology
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Humans
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Intracranial Arteriosclerosis
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physiopathology
3.The regulatory role of autophagy in tumor process.
Acta Pharmaceutica Sinica 2016;51(1):23-28
Autophagy is a classical regulatory mechanism of energy metabolism and self-update system in the maintenance of the intracellular homeostasis and cell development. Autophagy has been recently found to play a role in tumor development. Autophagy regulates tumor formation, proliferation, metastasis, and metabolism. At the same time, the anticancer drugs formed with autophagic mediators have been used in the treatment, which suggested that improving autophagy activity to inhibit tumor has become a new way for cancer treatment of cancer patients. This article gives an overview of the regulatory mechanism of autophagy, the relationship between autophagy and tumor, and tumor therapy by targeting autophagy.
Antineoplastic Agents
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Autophagy
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Humans
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Neoplasms
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physiopathology
4.Cognitive deficits in patients with brain tumor.
Chao SHEN ; Wei-Min BAO ; Bo-Jie YANG ; Rong XIE ; Xiao-Yun CAO ; Shi-Hai LUAN ; Ying MAO
Chinese Medical Journal 2012;125(14):2610-2617
OBJECTIVETo discuss the present status and progress of clinical research on the cognitive effects caused by different types of brain tumors and common treatments.
DATA SOURCESThe data used in this review were mainly from PubMed articles published in English from 1990 to Febuary 2012. Research terms were "cognitive deficits" or "cognitive dysfunction".
STUDY SELECTIONArticals including any information about brain tumor related cognitive deficits were selected.
RESULTSIt is widely accepted that brain tumors and related treatments can impair cognitive function across many domains, and can impact on patients' quality of life. Tumor localization, lateralization, surgery, drugs, radiotherapy and chemotherapy are all thought to be important factors in this process. However, some conflicting findings regarding brain tumor-related cognitive deficits have been reported. It can be difficult to determine the mechanism of these treatments, such as chemotherapy, antibiotics, antiepileptics, and steroids. Future research is needed to clarify these potential treatment effects.
CONCLUSIONSCognitive function is important for patients with brain tumor. Much more focus has been paid on this field. It should be regarded as an important prognostic index for the patients with brain tumor, and neuropsychological tests should be used in regular examinations.
Brain Neoplasms ; physiopathology ; Cognition ; physiology ; Cognition Disorders ; physiopathology ; Glioma ; physiopathology ; Humans
7.Relevance of cancer toxin pathogenesis theory with transformation of inflammation to carcinoma.
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(2):243-246
The "Cancer Toxin" pathogenesis theory is an innovate theoretical system for cancer pathogenesis of Chinese Medicine, which was built on the basis of "Cancer Toxin" concept initially raised by Professor ZHOU Zhong-ying. The mechanism of the transformation from inflammation to carcinoma has become one of hot-points in the field of cancer research at home and abroad in recent years. We focused on discussing the relevance of the "Cancer Toxin" pathogenesis theory with the transformation mechanism from inflammation to cancer, provided evidence for using "Cancer Toxin" pathogenesis theory in intervening transformation from inflammation to cancer, hoping to guide for Chinese medical prevention and treatment of tumor.
Biomedical Research
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Carcinoma
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physiopathology
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Humans
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Inflammation
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physiopathology
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Medicine, Chinese Traditional
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Neoplasms
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physiopathology
8.Hipbone biomechanical finite element analysis and clinical study after the resection of ischiopubic tumors.
He YA-QI ; Zhang XUE-LIN ; Tang BING-HANG ; Yang ANG
Chinese Medical Sciences Journal 2012;27(3):153-160
OBJECTIVETo investigate the changes of hipbone biomechanics after the resection of ischiopubic tumors and their relationships with the complications in the convalescent stage, and directing the postoperative pelvic reconstruction.
METHODSDICOM data were used to create an intact hipbone finite element model and postoperative model. The biomechanical indices on the same region in the two models under the same boundary condition were compared. The differences of displacement, stress, and strain of the two models were analyzed with statistical methods.
RESULTSThe distribution areas of the hipbone nodes' displacement, stress, and strain were similar before and after the simulated operation. The sacroiliac joint nodes' displacement (P=0.040) and strain (P=0.000), and the acetabular roof nodes' stress (P=0.000) and strain (P=0.005) of two models had significant differences, respectively.But the sacroiliac joint nodes' stress (P=0.076) and the greater sciatic notch nodes' stress (P=0.825) and strain (P=0.506) did not have significant differences.
CONCLUSIONSThe resection of ischiopubic tumors mainly affect the biomechanical states of the homolateral sacroiliac joint and acetabular roof. The complications in the convalescent stage are due to the biomechanical changes of the sacroiliac joint and the acetabular roof and disappearances of the stabilization and connection functions of the pubic symphysis and superior ramus of pubis.
Acetabulum ; physiopathology ; Biomechanical Phenomena ; Finite Element Analysis ; Humans ; Pelvic Bones ; physiopathology ; Pelvic Neoplasms ; physiopathology ; surgery ; Sacroiliac Joint ; physiopathology
9.Tumor mass in left chest wall.
Ren-ya ZHANG ; Jing GUO ; Xi-chao SUN ; Fang-fang XU ; Hong PAN ; Chuan-tao YUAN ; Peng ZHU
Chinese Journal of Pathology 2008;37(2):139-141