2.Diagnosis and surgical treatment of metachronous second primary lung cancer.
Fei-yue FENG ; De-chao ZHANG ; Xiang-yang LIU ; Yong-gang WANG ; You-sheng MAO
Chinese Journal of Surgery 2005;43(6):348-350
OBJECTIVETo review the experience of the diagnosis, surgical treatment and prognosis of metachronous second primary lung cancers.
METHODSBetween January 1983 and April 2004, 32 patients with metachronous second primary lung cancers were operated in our department. Clinical data of all these patients were reviewed retrospectively.
RESULTSThe initial procedures for their first primary lung cancers were lobectomy or pneumonectomy. Lobectomy or completion pneumonectomy for the second primary lung cancers were performed in 17 cases, limited pulmonary resection was done in 14 cases and exploration was in 1 case. The postoperative morbidity and mortality were 12% (4/32) and 3% (1/32), respectively. The 1-, 3-, and 5-year survival rate after second operation were 66% (19/29), 32% (9/28) and 19% (4/21), respectively.
CONCLUSIONSThe incidence of metachronous second primary lung cancers has been increasing gradually during recent years. The closely follow-up for patients undergoing resection for their first primary lung cancers is most important factor for improvement of the diagnosis of metachronous second primary lung cancers. Limited resection and incomplete lymph node dissection might be the factors contributing to the poor prognosis.
Adult ; Aged ; Female ; Humans ; Lung Neoplasms ; diagnosis ; mortality ; pathology ; surgery ; Lymph Node Excision ; Male ; Middle Aged ; Neoplasms, Second Primary ; diagnosis ; mortality ; pathology ; surgery ; Pneumonectomy ; methods ; Prognosis ; Retrospective Studies
3.Colonic Metastasis from Carcinoma of the Breast that Mimicks a Primary Intestinal Cancer.
Kazim UYGUN ; Zafer KOCAK ; Semsi ALTANER ; Irfan CICIN ; Fusun TOKATLI ; Cem UZAL
Yonsei Medical Journal 2006;47(4):578-582
Although the lung, liver, or bones are the most common location for distant metastases in breast cancer patients, metastases to the intestinal tract are very rarely recognized in the clinic. We will present an unusual case of colonic metastasis from a carcinoma of the breast that mimics a primary intestinal cancer, along with a through review of English language medical literature. Despite the fact that isolated gastrointestinal (GI) metastases are very rare and much less common than benign disease processes or second primaries of the intestinal tract in patients with a history of breast cancer, metastatic disease should be given consideration whenever a patient experiences GI symptoms.
Tomography, X-Ray Computed/methods
;
Neoplasms, Second Primary/diagnosis
;
Neoplasm Metastasis
;
Intestinal Neoplasms/*diagnosis
;
Humans
;
Female
;
Diagnosis, Differential
;
Colonic Neoplasms/*diagnosis/*secondary
;
Carcinoma/diagnosis/*pathology
;
Breast Neoplasms/diagnosis/*pathology
;
Breast/pathology
;
Adult
4.Lymphangiomatosis Involving the Inferior Vena Cava, Heart, Pulmonary Artery and Pelvic Cavity.
Dong Hun KIM ; Hye Sun SEO ; Jon SEO ; Hee Kyung KIM ; Keun HER ; Eun Ha SUK
Korean Journal of Radiology 2010;11(1):115-118
A 38-year-old woman who had undergone pelvic lymphangioma resection two months previously presented with cough and dyspnea. Transthoracic echocardiography and CT demonstrated the presence of a mixed cystic/solid component tumor involving the inferior vena cava, heart and pulmonary artery. Complete resection of the cardiac tumor was performed and lymphangioma was confirmed based on histopathologic examination. To the best of our knowledge, this is the first report of lymphangiomatosis with cardiac and pelvic involvement in the published clinical literature.
Adult
;
Female
;
Heart Neoplasms/diagnosis/*pathology
;
Humans
;
Lymphangioma/diagnosis/*pathology/surgery
;
Neoplasm Invasiveness
;
Neoplasms, Second Primary/diagnosis/*pathology
;
Pelvic Neoplasms/*pathology/surgery
;
Pulmonary Artery/*pathology
;
Vena Cava, Inferior/*pathology
5.Characteristics and Survival of Breast Cancer Patients with Multiple Synchronous or Metachronous Primary Cancers.
Janghee LEE ; Seho PARK ; Sanghwa KIM ; Jeeye KIM ; Jegyu RYU ; Hyung Seok PARK ; Seung Il KIM ; Byeong Woo PARK
Yonsei Medical Journal 2015;56(5):1213-1220
PURPOSE: Newly developed extra-mammary multiple primary cancers (MPCs) are an issue of concern when considering the management of breast cancer survivors. This study aimed to investigate the prevalence of MPCs and to evaluate the implications of MPCs on the survival of breast cancer patients. MATERIALS AND METHODS: A total of 8204 patients who underwent surgery at Severance Hospital between 1990 and 2012 were retrospectively selected. Clinicopathologic features and survival over follow-up periods of < or =5 and >5 years were investigated using univariate and multivariate analyses. RESULTS: During a mean follow-up of 67.3 months, 962 MPCs in 858 patients (10.5%) were detected. Synchronous and metachronous MPCs were identified in 23.8% and 79.0% of patients, respectively. Thyroid cancer was the most prevalent, and the second most common was gynecologic cancer. At < or =5 years, patients with MPCs were older and demonstrated significantly worse survival despite a higher proportion of patients with lower-stage MPCs. Nevertheless, an increased risk of death in patients with MPCs did not reach statistical significance at >5 years. The causes of death in many of the patients with MPCs were not related to breast cancer. Stage-matched analysis revealed that the implications of MPCs on survival were more evident in the early stages of breast disease. CONCLUSION: Breast cancer patients with MPCs showed worse survival, especially when early-stage disease was identified. Therefore, it is necessary to follow screening programs in breast cancer survivors and to establish guidelines for improving prognosis and quality of life.
Adult
;
Aged
;
Breast/pathology
;
Breast Neoplasms/diagnosis/*mortality
;
Female
;
Humans
;
Middle Aged
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Neoplasm Staging
;
Neoplasms, Multiple Primary/diagnosis/*mortality
;
Neoplasms, Second Primary/diagnosis/*mortality
;
Prognosis
;
*Quality of Life
;
Republic of Korea/epidemiology
;
Retrospective Studies
;
Survival Analysis
6.Metastasis of Colon Cancer to Medullary Thyroid Carcinoma: A Case Report.
So Jung YEO ; Kyu Jin KIM ; Bo Yeon KIM ; Chan Hee JUNG ; Seung Won LEE ; Jeong Ja KWAK ; Chul Hee KIM ; Sung Koo KANG ; Ji Oh MOK
Journal of Korean Medical Science 2014;29(10):1432-1435
Metastasis to the primary thyroid carcinoma is extremely rare. We report here a case of colonic adenocarcinoma metastasis to medullary thyroid carcinoma in a 53-yr old man with a history of colon cancer. He showed a nodular lesion, suggesting malignancy in the thyroid gland, in a follow-up examination after colon cancer surgery. Fine needle aspiration biopsy (FNAB) of the thyroid gland showed tumor cell clusters, which was suspected to be medullary thyroid carcinoma (MTC). The patient underwent a total thyroidectomy. Using several specific immunohistochemical stains, the patient was diagnosed with colonic adenocarcinoma metastasis to MTC. To the best of our knowledge, the present patient is the first case of colonic adenocarcinoma metastasizing to MTC. Although tumor-tumor metastasis to primary thyroid carcinoma is very rare, we still should consider metastasis to the thyroid gland, when a patient with a history of other malignancy presents with a new thyroid finding.
Adenocarcinoma/pathology/surgery
;
Biopsy, Fine-Needle
;
Carcinoma, Medullary/diagnosis/radiography/*secondary
;
Colonic Neoplasms/*pathology/surgery
;
Humans
;
Male
;
Middle Aged
;
Neoplasms, Second Primary/*diagnosis
;
Thyroid Gland/pathology
;
Thyroid Neoplasms/diagnosis/radiography/*secondary
;
Thyroid Nodule/diagnosis
7.Role of Transpedicular Percutaneous Vertebral Biopsy for Diagnosis of Pathology in Vertebral Compression Fractures.
Saurabh Shrinivas PAGDAL ; Sunil NADKARNI ; Sharad Moreshwar HARDIKAR ; Madan Sharad HARDIKAR
Asian Spine Journal 2016;10(5):925-929
STUDY DESIGN: Retrospective observational study. PURPOSE: To identify the role of percutaneous vertebral biopsy in histopathological diagnosis of vertebral compression fractures and to identify the frequency of unexpected malignancy in vertebral compression fractures. OVERVIEW OF LITERATURE: Vertebral compression fractures are common in the Indian population. Magnetic resonance imaging and nuclear imaging have some limitations in the diagnosis of definitive pathology of vertebral compression fractures. Therefore, histological confirmation is necessary for definitive diagnosis and to plan appropriate management for patient. METHODS: A retrospective observational study was conducted involving 84 patients who underwent percutaneous vertebral biopsy between 2010 and 2014. We performed C-arm guided percutaneous transpedicular core vertebral biopsy of vertebral compression fractures under combination of local anesthesia and intravenous conscious sedation. RESULTS: Sufficient biopsy material was obtained in 79 of the 84 cases. In the other five cases, biopsy material was not sufficient for reporting. Out of the 79 cases, osteoporotic pathology was detected in 69 patients, malignancy was detected in 8 patients and no pathology was found in 2 patients. Two patients with distant metastases to vertebra were identified. Primary spinal malignancy was detected in 6 patients (1 unsuspected plasmacytoma, 5 diagnosed malignancy preoperatively). So, the frequency of unsuspected malignancy of this study was 1.19% (1/84). None of the patients had any complications. CONCLUSIONS: C-arm guided percutaneous transpedicular vertebral biopsy is useful in obtaining definitive histopathological diagnosis of vertebral compression fractures, especially in differentiating malignant and non-malignant vertebral compression fractures and helping plan appropriate management of patients. The rate of unexpected malignancy in vertebral compression fracture was 1.19%.
Anesthesia, Local
;
Biopsy*
;
Biopsy, Needle
;
Conscious Sedation
;
Diagnosis*
;
Fractures, Compression*
;
Humans
;
Magnetic Resonance Imaging
;
Neoplasm Metastasis
;
Neoplasms, Second Primary
;
Observational Study
;
Osteoporosis
;
Pathology*
;
Plasmacytoma
;
Retrospective Studies
;
Spine
8.Metachronous Gastric MALT Lymphoma and Early Gastric Cancer: A Case Report.
Dong Beom SEO ; Kye Sook KWON ; Hyun Shin PARK ; Don Haeng LEE ; Hyung Gil KIM ; Yong Woon SHIN ; Young Soo KIM ; Joon Mi KIM
The Korean Journal of Gastroenterology 2007;49(4):245-250
Metachronous association between gastric lymphoma and early gastric cancer is a rare event. Recent studies have suggested that a relationship exists between gastric mucosa-associated lymphoid tissue (MALT) lymphoma and gastric carcinoma although the mechanism is unknown. Herein, we report a 53-year-old man who visited to our hospital due to melena. Esophagogastroduodenoscopy (EGD) revealed a MALT lymphoma on the greater curvature of lower body. The patient received anti-Helicobacter pylori eradication therapy, followed by 6 cycles of chemotherapy and radiation therapy, and achieved complete remission 12 months after the therapy. Three years later, he revisited our hospital with epigastric pain. EGD revealed an early gastric cancer on the anterior wall of proximal antrum, nearly opposite to the previous lymphoma site, and a partial gastrectomy was performed. To the best of our knowledge, this is the first case report of metachronous MALT lymphoma and subsequent gastric carcinoma in Korea.
Anti-Bacterial Agents/therapeutic use
;
Endoscopy, Digestive System
;
Gastric Mucosa/*pathology
;
Helicobacter Infections/drug therapy
;
Helicobacter pylori
;
Humans
;
Lymphoma, B-Cell, Marginal Zone/*diagnosis/pathology/radiotherapy
;
Male
;
Middle Aged
;
Neoplasms, Second Primary/*diagnosis/etiology
;
Stomach Neoplasms/*diagnosis/pathology
9.Metachronous Four Primary Malignancies in Gastro-intestinal Tract.
Jung Min BAE ; Se Won KIM ; Sang Woon KIM ; Sun Kyo SONG
The Korean Journal of Gastroenterology 2009;53(6):373-377
Multiple primary malignancy was reported firstly by Billroth in 1889. Recently, multiple primary malignancies are considered to increase due to improved survival rate of cancer patients, advanced diagnostic tools, and increased use of chemotherapy and radiotherapy. In Korea, several cases of triple primary malignancies were reported. However, four primary malignancies in gastro-intestinal tract was rarely reported. Recently, we experienced a 70 year-old male who was diagnosed with metachronous four primary malignancies in rectum, ascending colon, stomach, and ampulla of Vater. We report this rare case of metachronous four primary malignancies with a review of literature.
Adenocarcinoma/*diagnosis/pathology/surgery
;
Adenocarcinoma, Mucinous/diagnosis/surgery
;
Aged
;
Ampulla of Vater/*pathology
;
Colonic Neoplasms/diagnosis/surgery
;
Common Bile Duct Neoplasms/*diagnosis/pathology/surgery
;
Gastrointestinal Neoplasms/*diagnosis/pathology/radiography
;
Humans
;
Male
;
Neoplasms, Second Primary/*diagnosis/pathology
;
Rectal Neoplasms/diagnosis/surgery
;
Stomach Neoplasms/diagnosis/pathology/surgery
;
Tomography, X-Ray Computed
10.Extrapancreatic Tumors in Intraductal Papillary Mucinous Neoplasm of the Pancreas.
Seok Jin OH ; Se Joon LEE ; Hwal Youn LEE ; Yong Han PAIK ; Dong Ki LEE ; Kwan Sik LEE ; Jae Bock CHUNG ; Jeong Sik YU ; Dong Sup YOON
The Korean Journal of Gastroenterology 2009;54(3):162-166
BACKGROUND/AIMS: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas has a favorable prognosis, but seems to be associated with a high incidence of extrapancreatic tumors. The purpose of this study was to evaluate the incidence and clinicopathological features of extrapancreatic tumors associated with IPMN. METHODS: Thirty-seven patients with IPMN of the pancreas, confirmed by surgical resection and typical findings of endoscopic ultrasonography and CT imaging between October 1, 1998 and August 31, 2006 were included. Seventeen patients were diagnosed with surgical resection and biopsy, and others by typical imaging findings of IPMN. These patients were examined for the development of extrapancreatic tumors. RESULTS: Of 37 patients with IPMN, 14 (38%) had 18 extrapancreatic tumors, and 10 (27%) had 13 extrapancreatic malignancies. Five, six, and two extrapancreatic malignancies had diagnosed before during, and after the diagnosis of IPMN. Gastric adenocarcinoma (3 patients, 23%) and colorectal carcinoma (3 patients, 23%) were the most common neoplasms. Other extrapancreatic tumors included lung cancer (n=2), prostatic cancer (n=1), renal cell carcinoma (n=1), cholangiocelluar carcinoma (n=1), urinary bladder cancer (n=1), and gallbladder cancer (n=1), respectively. As benign tumor, there were two gallbladder adenoma, one gastric adenoma, one colonic adenoma and one benign ovarian cystic neoplasm, respectively. CONCLUSIONS: IPMN is associated with high incidence of extrapancreatic tumors, particularly gastric and colorectal neoplasms. Upper gastrointestinal endoscopy and colonoscopy should be done, and systemic surveillance for the possible occurrence of other tumors may allow early detection of extrapancreatic tumor in patients with IPMN.
Adenocarcinoma, Mucinous/*diagnosis/pathology/ultrasonography
;
Adult
;
Aged
;
Aged, 80 and over
;
Carcinoma, Pancreatic Ductal/*diagnosis/pathology/ultrasonography
;
Carcinoma, Papillary/*diagnosis/pathology/ultrasonography
;
Female
;
Humans
;
Incidence
;
Male
;
Middle Aged
;
Neoplasms, Multiple Primary/diagnosis/*epidemiology
;
Neoplasms, Second Primary/diagnosis/*epidemiology
;
Pancreatectomy
;
Pancreatic Neoplasms/*diagnosis/pathology/ultrasonography
;
Retrospective Studies
;
Tomography, X-Ray Computed