Humans ; Lung Neoplasms/pathology* ; Neoplasms, Multiple Primary/pathology*

Aged ; Female ; Humans ; Neoplasms, Multiple Primary ; pathology ; physiopathology ; Neoplasms, Second Primary ; pathology ; physiopathology

Angiomyolipoma ; pathology ; Humans ; Kidney Neoplasms ; pathology ; Lung Neoplasms ; pathology ; Lymphangioleiomyomatosis ; pathology ; Neoplasms, Multiple Primary ; pathology

Adult ; Breast Neoplasms ; pathology ; Female ; Humans ; Neoplasms, Multiple Primary ; pathology ; Sarcoma, Myeloid ; pathology ; Spinal Neoplasms ; pathology

A carcinoid tumor of the thymus combined with thymoma in a 62-year-old man is described. The mediastinal tumor had been present for 13 years and was associated with pure red cell aplasia. Carcinoid tumor occupied the central two-thirds of the tumor, consisting of nests and trabeculae of monotonous round cells, which ultrastructurally showed many intracytoplasmic dense-core granules. Typical spindle cell type thymoma surrounded the carcinoid area. Clinico-pathologic findings of this unique case suggested that the carcinoid tumor developed within a preexisting thymoma, illustrating a possibility of neuroendocrine differentiation of thymic epithelial cells.
Carcinoid Tumor/*pathology ; Humans ; Male ; Middle Aged ; Neoplasms, Multiple Primary/*pathology ; Thymoma/*pathology ; Thymus Neoplasms/*pathology

Carcinoid tumors show variety of pathological features and some of them are admixed with adenocarcinoma. The carcinoma-carcinoid spectrum is a concept of classifying tumors based on the tumor mass differentiation which is composed of tissues of both endocrine and nonendocrine functions. When two types of tissues exist within one tumor intermingled with each other in a similar proportion, it is called composite tumor. On the other hand, collision tumor is characterized by the presence of two localized tissue types adjacently together. Gastric composite tumors are relatively rare. According to the reports on the Korean literature, there are several collision tumors, but only one case of gastric composite tumor has been cited. Reports of multiple synchronous or metachronous cancers have increased steadily during the last decades. Multiple gastric carcinoids or carcinoid tumors developed in association with gastric adenocarcinoma contribute to this trend. We report one case of gastric composite tumor simultaneously occurring with a early gastric adenocarcinoma with review of the literature.
Adenocarcinoma/*pathology ; Carcinoid Tumor/*pathology ; Humans ; Male ; Middle Aged ; Neoplasms, Multiple Primary/*pathology ; Stomach Neoplasms/*pathology

No abstract available.
Carcinoma, Hepatocellular/*pathology ; Cholangiocarcinoma/*pathology ; Female ; Human ; Liver Neoplasms/*pathology ; Middle Aged ; Neoplasms, Multiple Primary/*pathology

Female ; Humans ; Melanoma/surgery* ; Neoplasms, Multiple Primary/pathology* ; Ovarian Neoplasms/pathology* ; Skin Neoplasms ; Teratoma/surgery*

Female ; Heart Atria ; pathology ; Heart Neoplasms ; pathology ; Humans ; Middle Aged ; Neoplasms, Multiple Primary ; pathology ; Sarcoma ; pathology ; Tonsillar Neoplasms ; pathology

Carcinoma ; pathology ; Endometrial Neoplasms ; pathology ; Female ; Humans ; Neoplasms, Multiple Primary ; pathology ; Ovarian Neoplasms ; pathology ; Sex Cord-Gonadal Stromal Tumors ; pathology