1.Multiple primary malignant neoplasms of three early cancer lesions: a case report.
Wan-jun ZHANG ; Xiao-ping QIAN ; Yu SHI ; Wen-sheng PAN ; Xiang XU ; Zai-yuan YE ; Liang-qin WU ; Takeshi TERAI ; Nobuhiro SATO ; Sumio WATANABE
Chinese Medical Journal 2011;124(8):1278-1280
Multiple primary malignant neoplasms (MPMNs) are rarely reported and it is important to give early diagnosis and proper therapy for these patients. Here reported a case of 62-year-old man with concomitant three early stage cancer lesions in upper gastrointestinal tract, all of which were detected by endoscopy. The first one was an IIc-type lesion at angular part of stomach under endoscopy, which was histologically confirmed to be a mucosal well-differentiated adenocarcinoma. The patient underwent a standard radical gastrectomy for the lesion after the failure of endoscopic treatment. The other two neoplasms were observed during follow-up and were indicated as early stage lesions by synthesizing information from endoscopy, endoscopic ultrasonography, computed tomography and biopsy. One displayed as a hyperemic patch (3 cm×4 cm in size) located at the part of esophagus 27 cm away from the incisor teeth and was proved to be moderately differentiated squamous cancer by histopathological examination. The other was an IIc-type lesion (3.0 cm×3.5 cm in size) located at the part of esophagus 36 cm away from the incisor teeth, and the biopsy result showed a poorly differentiated squamous carcinoma. Both the two lesions were treated with radical radiation because the patient refused surgery management. No recurrence of former lesions or occurrence of novel lesions were observed during post-treatment follow-up, suggesting radical radiation might be effective for this patient.
Gastrointestinal Neoplasms
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diagnosis
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Humans
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Male
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Middle Aged
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Neoplasms, Multiple Primary
;
diagnosis
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Upper Gastrointestinal Tract
;
pathology
2.Multicentric osteosarcoma.
Shamsi HAMEED ; Sandeep VIJAYAN ; Monappa NAIK ; Sharath RAO
Singapore medical journal 2012;53(10):e214-7
Multicentric osteosarcoma is a rare type of osteosarcoma with a poor prognosis. It is usually described as the occurrence of tumorous lesions in more than one bone, but without pulmonary metastasis. It may be of a synchronous or metachronous variety. We report the case of a 12-year-old boy with a synchronous variety of multicentric osteosarcoma, although he did not have any risk factors for the disease. We also discuss the current debate on whether multicentric osteosarcoma represents multiple primary tumours or metastatic disease.
Bone Neoplasms
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diagnosis
;
pathology
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Child
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Femoral Neoplasms
;
diagnosis
;
pathology
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Humans
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Humerus
;
pathology
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Male
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Neoplasms, Multiple Primary
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diagnosis
;
pathology
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Osteosarcoma
;
diagnosis
;
pathology
;
Prognosis
3.Gastritis Cystica Profunda Accompanied by Multiple Early Gastric Cancers.
Sun You MOON ; Kyoung Oh KIM ; Sang Hoon PARK ; Kyo Sang YOO ; Cheol Hee PARK ; Jong Hyeok KIM ; Choong Kee PARK ; Sun young JUN
The Korean Journal of Gastroenterology 2010;55(5):325-330
Gastritis cystica profunda (GCP) is a rare disease which shows multiple cystic gastric glands within the submucosa of the stomach. GCP lesions mainly develop at the site of gastroenterostomy and exhibit benign behavior. However, there have been a number of debates over its malignant potential. Several reports have documented GCP accompanied by gastric carcinomas, but the relationship between the two conditions remains uncertain. Here we report two cases of GCP with dysplasia accompanied by synchronous multiple early gastric cancers without previous gastric surgery.
Aged
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Cysts/*diagnosis/pathology
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Early Detection of Cancer
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Gastric Mucosa/pathology
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Gastritis/complications/*diagnosis/pathology
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Humans
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Male
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Neoplasms, Multiple Primary/*diagnosis/pathology
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Stomach Neoplasms/complications/*diagnosis/pathology
4.Gastritis Cystica Profunda Accompanied by Multiple Early Gastric Cancers.
Sun You MOON ; Kyoung Oh KIM ; Sang Hoon PARK ; Kyo Sang YOO ; Cheol Hee PARK ; Jong Hyeok KIM ; Choong Kee PARK ; Sun young JUN
The Korean Journal of Gastroenterology 2010;55(5):325-330
Gastritis cystica profunda (GCP) is a rare disease which shows multiple cystic gastric glands within the submucosa of the stomach. GCP lesions mainly develop at the site of gastroenterostomy and exhibit benign behavior. However, there have been a number of debates over its malignant potential. Several reports have documented GCP accompanied by gastric carcinomas, but the relationship between the two conditions remains uncertain. Here we report two cases of GCP with dysplasia accompanied by synchronous multiple early gastric cancers without previous gastric surgery.
Aged
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Cysts/*diagnosis/pathology
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Early Detection of Cancer
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Gastric Mucosa/pathology
;
Gastritis/complications/*diagnosis/pathology
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Humans
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Male
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Neoplasms, Multiple Primary/*diagnosis/pathology
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Stomach Neoplasms/complications/*diagnosis/pathology
5.A Case Report of Synchronous Double Primary Liver Cancers Combined with Early Gastric Cancer.
Jae Young CHANG ; Byung Ho KIM ; Sung Wha HONG ; Youn Wha KIM ; Joo Hyeong OH
The Korean Journal of Internal Medicine 2003;18(2):115-118
Combined hepatocellular carcinoma and cholangiocarcinoma is found at a frequency of 1.0~6.3% in resected primary hepatic tumors. However, the case of double cancers of hepatocellular carcinoma and cholangiocarcinoma that are discovered synchronously in different lobes of a liver is very rare. We experienced a case of a 74-year-old man who was found to have hepatocellular carcinoma and cholangiocarcinoma in different lobes of the liver, which were accompanied by early gastric cancer. To our knowledge, this is the first case report of double primary hepatic cancers accompanied with early gastric cancer. The pathogenesis and previous related reports of these lesions are discussed.
Adenocarcinoma/diagnosis
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Aged
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Bile Duct Neoplasms/diagnosis
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Bile Ducts, Intrahepatic/pathology
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Carcinoma, Hepatocellular/diagnosis
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Cholangiocarcinoma/diagnosis
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Human
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Liver Neoplasms/*diagnosis
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Male
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Neoplasms, Multiple Primary/*diagnosis
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Stomach Neoplasms/*diagnosis
6.An unusual collision tumour masquerading as a basal cell carcinoma on the nose.
Hwee Chyen LEE ; Ki Wei TAN ; Min Wee CHIA ; Chee Seng SIM
Singapore medical journal 2012;53(12):e267-8
When two or more cutaneous tumours coexist in a single lesion, it is known as a cutaneous collision or contiguous tumour. Various combinations of collisions have been described. Collision tumours often have misleading clinical and histological presentations, and can be a diagnostic challenge. Chondroid syringomas are mixed cutaneous tumours of dual origin, and like collision tumours, are often confused with the more commonly seen cutaneous lesions. As chondroid syringomas are rare, their involvement in collision tumours is an even more peculiar occurrence. We report an unusual case of a cutaneous collision tumour on the nose involving an intradermal naevus and chondroid syringoma. To the best of our knowledge, this is the first time such a combination is reported.
Aged
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Carcinoma, Basal Cell
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diagnosis
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Diagnosis, Differential
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Female
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Humans
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Keratosis, Seborrheic
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pathology
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Neoplasms, Multiple Primary
;
pathology
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Nevus, Pigmented
;
pathology
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Nose Neoplasms
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diagnosis
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Skin Neoplasms
;
pathology
7.Combined Hepatocellular-cholangiocarcinoma.
Joon Koo HAN ; Se Hyung KIM ; Soo Jin KIM
The Korean Journal of Hepatology 2007;13(1):112-115
8.Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma.
Yoon Jung CHOI ; Tai Seung KIM
Yonsei Medical Journal 1994;35(2):239-243
Sarcomatous transformation in chordoma (dedifferentiated chordoma) is a very rare condition and has been emphasized as a distinct entity because of its more aggressive clinical course. Here we describe a case of dedifferentiated chordoma (chordoma associated with malignant fibrous histiocytoma) arising from the sacrococcygeal region of a 55-year-old woman. The results of immunohistochemical stain in the chordoma area were strong positive for cytokeratin, epithelial membrane antigen and S-100 protein. The spindle and giant cells in the transitional areas of chordoma and malignant fibrous histiocytoma were positive for cytokeratin and epithelial membrane antigen in addition to vimentin and alpha-1-antichymotrypsin. The spindle and giant cells in the central area of malignant fibrous histiocytoma were negative for cytokeratin and epithelial membrane antigen, but positive for vimentin and alpha-1-antichymotrypsin. This supports the pathogenesis of sarcomatous transformation from chordoma.
Case Report
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Chordoma/diagnosis/*pathology
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Female
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Histiocytoma, Fibrous/diagnosis/*pathology
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Human
;
Immunohistochemistry
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Middle Age
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Neoplasms, Multiple Primary/*pathology
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Pelvic Neoplasms/diagnosis/*pathology
9.A Case of Synchronous Colonic Laterally Spreading Tumors Treated by Sequential Endoscopic Submucosal Dissection Performed on Two Consecutive Days.
Min Jung KIM ; Jung Eun LEE ; Sung Jae KIM ; Kyung Hoon KIM ; Eun Soo KIM ; Kwang Bum CHO ; Kyung Sik PARK
The Korean Journal of Gastroenterology 2010;56(3):196-200
Endoscopic submucosal dissection (ESD) is an useful therapeutic technique for large gastrointestinal epithelial tumors that it provides an en bloc resection. Although there is some controversy about the role of ESD for colorectal lesions, for large lesions in the distal rectum, ESD has the advantage of preserving anal function. However, the large amount of insufflating gas used during the procedure can cause severe abdominal pain and discomfort. Moreover, high intra-luminal pressure caused by a by large amount of gas can cause a micro-perforation. There is no consensus as to whether ESD is the optimal treatment for synchronous large colorectal laterally spreading tumors (LSTs) that cannot be removed en-bloc by conventional endoscopic mucosal resection. Here, a case with two neighboring synchronous large LSTs, one located in the rectum and the other in the distal sigmoid colon, were sequentially removed by separate ESD procedures performed on two consecutive days in a patient who could not tolerate a long procedure.
Adenoma, Villous/diagnosis
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Colonoscopy
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Colorectal Neoplasms/*diagnosis/pathology/surgery
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*Dissection
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Humans
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Intestinal Mucosa/pathology/surgery
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Male
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Middle Aged
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Neoplasms, Multiple Primary/*diagnosis/pathology/surgery
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Rectum/pathology
10.Is Gastric Cancer a New Indication for Surveillance Colonoscopy? Colon Cancer is Increased in Gastric Cancer Patients.
Se Yong OH ; Dong Il PARK ; Tae Woo YOO ; Mun Su KANG ; Sang Hoon KIM ; Jung Ho PARK ; Hong Joo KIM ; Yong Kyun CHO ; Chong Il SOHN ; Woo Kyu JEON ; Byung Ik KIM ; Byung Ho SON ; Chang Hak YOO
The Korean Journal of Gastroenterology 2006;47(3):191-197
BACKGROUND/AIMS: It has been reported that the risk of gastric polyp is increased in various colonic polyposis syndromes or in series of patients with sporadic colonic polyps. However, there are only a few large case controlled studies of colon cancer incidence in gastric cancer patients who underwent colonoscopy. The aims of this study were to determine the incidence of colorectal neoplasm and to evaluate the necessity of colonoscopic surveillance in patients with gastric cancer. METHODS: We performed colonoscopy in 105 patients with gastric cancer who agreed to undergo colonoscopy before or after 6 months from gastric resection between January 2002 and December 2004 in Kangbuk Samsung hospital. As a control group, 269 consecutive, age and sex matched patients without gastric neoplasm on gastroscopy who underwent colonoscopy within 6 months for the evaluation of various gastrointestinal symptoms during the year 2004 were included. Endoscopic reports and pathological results were reviewed retrospectively. RESULTS: In the patient group, adenomatous polyps were diagnosed in 24/105 patients (22.9%) and colorectal adenocarcinoma in 10/105 patients (9.5%). In the control group, adenomatous polyps were diagnosed in 78/269 patients (29.0%) and colorectal adenocarcinoma in 2/269 patients (0.7%). The incidence of colorectal adenocarcinoma between the patient group and control group showed significant differences (odds ratio 11.04, p=0.003). CONCLUSIONS: The risk of colorectal adenocarcinoma increases significantly in patients with gastric cancer. We suggest that the patients with gastric cancer might carry a high risk for colorectal cancer whom require surveillance colonoscopy.
Adenocarcinoma/*diagnosis/*secondary
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Adenomatous Polyps/diagnosis
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Colonic Polyps/diagnosis
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*Colonoscopy
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Colorectal Neoplasms/*diagnosis/*secondary
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Female
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Humans
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Male
;
Middle Aged
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Neoplasms, Multiple Primary/*diagnosis
;
Stomach Neoplasms/*pathology