A study on 537 cases of gastrotrectomy due to the cancer in Viet Duc hospital during 1993-1997 has shown that the gastric cancer that did not belong to the glandular epithelioma accounted for 23 cases (4.3%) of which malignant lymphoma (12/23), malignant peripheral neuroma (7/2) and smooth muscelar tumor (3/23). Most of them hospitalized due to the abdominal pain, 1 cases of gastric perforation and 2 cases of digestive haemorrhage, 12 cases found the abdominal tumor 7 cases had lesion in the cardiapyloric region. The treatment involved the half total gastrectomy and tumor disection, 2 cases received the left hepatic lobe disection, 3 cases of splenectomy. There were no cases treated by the combination of chemotherapy and radiation.
Stomach Neoplasms ; Neoplasms, Glandular and Epithelial ; diagnosis ; therapeutics

Diagnosis, Differential ; Humans ; Neoplasms, Glandular and Epithelial ; diagnosis ; Thymus Neoplasms ; diagnosis

Endoscopic biopsy is the most popular diagnostic procedure for gastric epithelial neoplasm. However, discrepancy between biopsy and endoscopic resection diagnosis occasionally occurs and leads to an unnecessary procedure. A negative pathologic diagnosis following endoscopic resection is particularly problematic. In this context, we reviewed factors that may be associated with a diagnostic discrepancy between endoscopic biopsy and endoscopic resection, with focus on crypt dysplasia.
Biopsy ; Diagnosis ; Neoplasms, Glandular and Epithelial ; Stomach ; Unnecessary Procedures

BACKGROUND/AIMS: Endoscopic resection (ER) is a well-established treatment modality for gastric epithelial neoplasm. However, there is a discrepancy between forceps biopsy and ER specimen pathology, including a negative pathologic diagnosis (NPD) after ER. It has been suggested that pit dysplasia (PD) is a subtype of gastric dysplasia, and the aim of this study was to assess the significance of PD in cases with NPD after ER for early gastric neoplasms. METHODS: After ER, 29 NPD lesions that had an associated pretreatment forceps biopsy specimen, were correctly targeted during ER, and had no cautery artifact on the resected specimen were included in this study. RESULTS: Sixteen lesions showed PD and 13 had no neoplastic pathology. The initial pretreatment forceps biopsy diagnoses of 29 NPD lesions were low-grade dysplasia (LGD) in 17 lesions, high-grade dysplasia (HGD) in seven lesions, and adenocarcinoma in five lesions, which after review were revised to PD in 19 lesions, LGD in four lesions, adenocarcinoma in two lesions, and no neoplastic pathology in four lesions. Overall, nine lesions (31%) were small enough to be removed by forceps biopsy, four NPD lesions (14%) were initially misinterpreted as neoplastic lesions, and 16 PD lesions (55%) were misinterpreted as NPD lesions on ER slides. CONCLUSIONS: Approximately half of the lesions initially diagnosed as LGD or HGD were subsequently classified as PD. Therefore, including PD as a subtype of gastric dysplasia could reduce the diagnostic discrepancy between initial forceps biopsy and ER specimens.
Adenocarcinoma ; Artifacts ; Biopsy ; Cautery ; Diagnosis ; Neoplasms, Glandular and Epithelial* ; Pathology* ; Stomach ; Stomach Neoplasms ; Surgical Instruments

OBJECTIVE: We were trying to identify the expression of Wnt 1 and beta-catenin in normal ovarian epithelium and epithelial ovarian tumor. METHODS: We used archival formalin-fixed and paraffin-embedded tissues from Comprehensive Gynecologic Cancer Center and the Department of Pathology at Bundang CHA Hospital from 2000 to 2005. Immunohistochemical staining for Wnt 1 and beta-catenin was performed on the ovarian epithelial tissues. Statistical analyses were performed with SPSS 10.1 for Windows and significance was defined as P<0.05. RESULTS: Of 114 cases, the cases were composed of 54 carcinomas, 40 borderline tumors, 12 benign tumors and 8 normal control ovarian tissues. Abnormal nucleocytoplasmic expression of beta-catenin was found in 4 endometrioid carcinomas. The nuclear expression of beta-catenin was found especially in the components of the endometrioid carcinoma (28.6%, P<0.05). Wnt 1 was overexpressed in all 9 clear cell carcinomas, but not frequent in the other types of malignant tumors (P<0.05). We found a statistically significant correlation between beta-catenin nuclear localization and endometrioid carcinomas. And we found a significant correlation between Wnt 1 expression and clear cell carcinomas. CONCLUSION: It does not seem that Wnt 1 over expression directly provoke the nuclear localization of beta-catenin. But, deregulation of beta-catenin and Wnt 1 may play a role in the pathogenesis of ovarian epithelial carcinogenesis of endometriod carcinoma and clear cell carcinoma. Evaluating this avenue of regulation of beta-catenin and Wnt protein in ovarian epithelial carcinoma may provide a new direction for early diagnosis and treatment in ovarian epithelial carcinoma and provide opportunities for making a certain biomarkers.
beta Catenin ; Carcinoma, Endometrioid ; Early Diagnosis ; Epithelium ; Neoplasms, Glandular and Epithelial ; Ovarian Neoplasms

The descriptive term "mixed epithelial and stromal tumor of the kidney" was recently proposed for a group of renal tumors characterized histologically by a mixture of stromal and epithelial proliferation. It is a rare benign neoplasm of the kidney which has been reported under various names such as adult type mesoblastic nephroma or others. We report a case of mixed epithelial and stromal tumor in a 47 yr old female patient presenting as a partly cystic and partly solid renal mass. Microscopically, the tumor exhibited spindle cell component in solid portion and epithelial proliferation around microcystic areas. Immunoreactive profiles and ultrastructural examination suggested myofibroblastic nature of the stromal cells. We believe this case exemplifies a unique adult renal tumor displaying both epithelial and stromal neoplastic component and has a few unusual features worthy of attention.
Nephroma, Mesoblastic/pathology ; Neoplasms, Glandular and Epithelial/*pathology ; Middle Aged ; Kidney Neoplasms/*pathology ; Humans ; Female ; Diagnosis, Differential

Primary fallopian tube carcinoma (PFTC) is a rare tumor that histologically and clinically resembles epithelial ovarian cancer. PFTC has a worse prognosis than ovarian cancer as it is not routinely suspected and so treatment may be delayed. The early clinical manifestations and a prompt investigation can often lead to a correct diagnosis at an early stage. The preoperative diagnosis is usually difficult, and most patients with PFTC undergo laparotomy with the presumed diagnosis of ovarian carcinoma according to the presence of an adnexal mass. PFTC can present preoperatively as a tubo-ovarian abscess and it should be considered in the differential diagnosis of acute pelvic peritonitis. PFTC should be suspected by clinicians even if the presenting symptoms are atypical. We report here on two cases of PFTC along with a brief review of the literature.
Abscess ; Diagnosis, Differential ; Fallopian Tubes ; Female ; Humans ; Laparotomy ; Neoplasms, Glandular and Epithelial ; Ovarian Neoplasms ; Peritonitis ; Prognosis

BACKGROUND: Solid and papillary neoplasms of the pancreas are very rare tumors that occur predominantly in young women. Most of them are diagnosed because of their large sizes and because they are present with an asymptomatic abdominal mass. Most reports indicate that these large palpable, abdominal masses occur in females in their second and third decades of life. Only a few cases of solid and papillary epithelial neoplasms of the pancreas have been reported. METHOD: Here in, eight cases were reviewed which were treated at the Department of Surgery, Catholic University Medical College affiliated hospital from 1988 to 1996. RESULT: The diagnosis is often implied by radiologic examination with ultrasonography, UGI, ERCP, and computed tomography. Most cases showed well-encapsulated, round, or lobulated masses consisting of both cystic and solid areas. The hallmark histologic pattern of this tumor is a solid and papillary epithelial pattern in a pancreatic neoplasm. There is no specific marker for this neoplasm which could elucidate the obscure histogenetic origin and the phenotypic differentiation. Concluion: Therefore, surgical excision is the primary form of treatment and has favorable results.
Cholangiopancreatography, Endoscopic Retrograde ; Diagnosis ; Female ; Humans ; Neoplasms, Glandular and Epithelial* ; Pancreas* ; Pancreatic Neoplasms ; Ultrasonography

Solid and papillary epithelial neoplasm (SPEN) of the pancreas is a rare tumor with low malignant potentiality that usually occurs in young females. Preoperative evaluation, especially radiologic tests, including ultrasonography and CT scan, is helpful in the diagnosis. These studies demonstrate a well-demarcated large mass with solid and cystic portions, frequently in the tail or body of the pancreas. Complete resection is usually curative, however local invasion and/or metastasis may occur. The authors report a case of a solid and papillary epithelial neoplasm of the pancreatic body in a 14-year old child at St. Benedict Hospital and review the literature.
Adolescent ; Child* ; Diagnosis ; Female ; Humans ; Neoplasm Metastasis ; Neoplasms, Glandular and Epithelial* ; Pancreas* ; Tomography, X-Ray Computed ; Ultrasonography

BACKGROUND: Primary thymic epithelial neoplasm is a type of mediastinal tumors that have various biologic and morphologic features. In this study, we reclassified 59 cases of thymic epithelial tumors by the new WHO classification. We inquired whether the new WHO classification has independent prognostic relevance by analyzing clinical characteristics of thymic epithelial tumors including Masaoka's clinical stage. MATERIAL AND METHOD: From December 1986 to August 2003, 59 patients who underwent surgery in the Keimyung University Dongsan Medical Center with definite diagnosis of thymic epithelial tumor were studied. We analyzed the histologic subtype (WHO classification), clinical stage (Masaoka's clinical stage) and patient's characteristics (sex, age, myasthenia gravis, tumor size, invasion, recurrence, metastasis) as prognostic factors. We analyzed the relationship between histologic subtype and clinical stage. RESULT: 32 patients were male and 27 were female. Mean age was 50.1+/-14.2. From WHO A to C, all thymic epithelial tumors were reclassified by the new WHO classification. Six patients (10.2%) had Type A, 7 (11.9%) had Type AB, 7 (11.9%) had Type B1, 10 (16.9%) had Type B2 and 7 (11.9%) had Type B3, 22 (37.3%) had Type C. Two factors were shown by multivariate analysis to be associated with a favorable prognosis: completeness of resection (p=0.003) and non-invasiveness (p=0.001). The overall 5-year survival of the 59 patients was 53%, subtype A and AB were 92.3%, B1 and B2 were 70.2%, and B3 and C were 26.1%. The association between histologic subtype and invasive behavior (stage) was statistically significant (p<0.001). CONCLUSION: The WHO classfication is not only a histologic classfication of the thymic epithelial tumors but also a significant prognostic factor that influence the survival of thymic epithelial tumors.
Classification* ; Diagnosis ; Female ; Humans ; Male ; Multivariate Analysis ; Myasthenia Gravis ; Neoplasms, Glandular and Epithelial ; Prognosis ; Recurrence ; Thymoma