No abstract available.
Neoplasm, Residual*

No abstract available.
Leukemia* ; Neoplasm, Residual*

No abstract available.
Gallium* ; Neoplasm, Residual* ; Wounds and Injuries*

BACKGROUND: The principle of Mohs micrographic surgery is to examine microscopically the entire peripheral margin of an excised tissue specimen to precisely localize the site of any residual tumor and enable its subsequent removal. In processing in the tissue for frozen horizontal sections, a technical difficulty arises in manipulating the deep and lateral margins into the same flat plane. OBJECTIVE: Our aim was to develop a new method allowing the optimal tissue preperation for Mohs micrographic smgery and to evaluate the usefulness of this methad. METHODS: The technique involves conversion of a non-planar surgical margin to a planar surface by applying and freezing the specimen against a flat glass surface. We compared this modified method used in our laboratory with standard methods for tissue preparation of Mohs micrographic surgery.
Freezing ; Glass ; Mohs Surgery ; Neoplasm, Residual

Interpretation of the pathologic margin of a specimen from a resected tumor is important because local recurrence can be predicted by the presence of tumor cells in the resection margin. Although a sufficient resection margin is recommended in the resection of gastrointestinal adenocarcinoma, it is not usually regarded strictly in cases of mesenchymal tumor, especially gastrointestinal stromal tumor (GIST), because the tumor is usually encapsulated or well demarcated, and not infiltrative. Therefore, margin positivity is not rare in the pathological evaluation of surgically or endoscopically resected GIST, and does not always indicate incomplete resection. Although a GIST may have a tumor-positive pathologic margin, complete resection may be achieved if no residual tumor is visible, and long-term survival can be predicted as in the cases with a negative pathologic margin.
Adenocarcinoma ; Gastrointestinal Stromal Tumors* ; Neoplasm, Residual ; Recurrence

This report describes the usefulness of positron emission tomography-computed tomography (PET-CT) for evaluating recurrent or residual tumors following surgery. CT and 18F-fluorodeoxyglucose PET-CT were pre- and post-operatively applied to multiple masses in a dog with hemangiosarcoma. The distinction between the left subcutaneous mass and the peritoneum was clarified on pre-operative CT examination, and malignancy was suspected based on PET-CT. A recurrent or residual tumor in the left subcutaneous region was suspected on post-operative PET-CT, and confirmed through histopathologic examination.
Animals ; Dogs ; Electrons* ; Hemangiosarcoma* ; Neoplasm, Residual ; Peritoneum

In prostate cancer patients without local invasion and metastasis, radical prostatectomy is performed as a rule for the resection of residual cancer. In a few cases, little amount of cancer volume is identified in radical prostatectomy specimens. This finding has been described as 'minimal residual cancer' or 'vanishing cancer phenomenon' and some reports have demonstrated an increase in the incidence of minimal residual prostate cancer. However, only few cases with 'minimal residual cancer' or 'no residual cancer' despite efforts searching for other possibilites have been reported. We report a case of no residual cancer in radical prostatectomy specimens of biopsy-proven prostate cancer.
Humans ; Incidence ; Neoplasm Metastasis ; Neoplasm, Residual* ; Prostate* ; Prostatectomy* ; Prostatic Neoplasms*

OBJECTIVE: To evaluate the significance of the expression of HER-2/neu oncoprotein as a prognostic factor, we retrospectively examined its overexpression rates in epithelial ovarian cancer and their relationships with prognostic factors. METHODS: Immunohistochemistry for Her-2/neu oncoprotein was performed on formalin-fixed, paraffin-embedded tissues from 45 epithelial ovarian cancer operated between 1999 and 2002. We analyzed relationships between the overexpression of HER-2/neu oncoprotein and prognostic factors including age, histologic type, surgical stage, residual tumor > or =2 cm, and recurrence. RESULTS: The rate of overexpression of HER-2/neu oncoprotein in epithelial ovarian cancer was 31.1% (14/47). The overexpression of HER-2/ neu oncoprotein showed associations with residual tumor > or =2 cm (p=0.049) and recurrence (p=0.029) in univariate analysis. But, there were no associations between the overexpression of HER-2/neu oncoprotein and overall survival. CONCLUSION: The overexpression of HER-2/neu oncoprotein was associated with residual tumor and recurrence in univariate analysis, but appeared to have no prognostic significance for overall survival of epithelial ovarian cancer. Further and larger prospective studies using multivariate analysis are necessary to establish the clinical applicability of these observations.
Immunohistochemistry ; Multivariate Analysis ; Neoplasm, Residual ; Ovarian Neoplasms* ; Recurrence ; Retrospective Studies

Parathyroid carcinoma is a rare endocrine malignancy accounting for 0.5% to 4.0% of all cases of hyperparathyroidism and commonly present as hypercalcemia and parathyroid hormone (PTH) elevation. Nonfunctional parathyroid carcinoma does not show symptoms of hyperparathyroidism and only showed a vague indication of being pathologic, even when detected late. The optimal treatment is en bloc resection of the cancer, but frequent local recurrence after surgery has been reported. Adjuvant local treatment such as radiotherapy may improve the likelihood local control in cases with incompletely resected or microscopic residual tumor. The results of this study point to a case of nonfunctional parathyroid carcinoma treated by external beam radiotherapy after en-bloc resection of cancer.
Accounting ; Hypercalcemia ; Hyperparathyroidism ; Neoplasm, Residual ; Parathyroid Hormone ; Parathyroid Neoplasms ; Recurrence

To determine the clinical target volumes considering vascularity and cellularity of tumors, the software was developed for mapping of the analyzed biological clinical target volumes on anatomical images using regional cerebral blood volume (rCBV) maps and apparent diffusion coefficient (ADC) maps. The program provides the functions for integrated registrations using mutual information, affine transform and non-rigid registration. The registration accuracy is evaluated by the calculation of the overlapped ratio of segmented bone regions and average distance difference of contours between reference and registered images. The performance of the developed software was tested using multimodal images of a patient who has the residual tumor of high grade gliomas. Registration accuracy of about 74% and average 2.3 mm distance difference were calculated by the evaluation method of bone segmentation and contour extraction. The registration accuracy can be improved as higher as 4% by the manual adjustment functions. Advanced MR images are analyzed using color maps for rCBV maps and quantitative calculation based on region of interest (ROI) for ADC maps. Then, multi-parameters on the same voxels are plotted on plane and constitute the multi-functional parametric maps of which x and y axis representing rCBV and ADC values. According to the distributions of functional parameters, tumor regions showing the higher vascularity and cellularity are categorized according to the criteria corresponding malignant gliomas. Determined volumes reflecting pathological and physiological characteristics of tumors are marked on anatomical images. By applying the multi-functional images, errors arising from using one type of image would be reduced and local regions representing higher probability as tumor cells would be determined for radiation treatment plan. Biological tumor characteristics can be expressed using image registration and multi-functional parametric maps in the developed software. The software can be considered to delineate clinical target volumes using advanced MR images with anatomical images.
Axis, Cervical Vertebra ; Blood Volume ; Diffusion ; Glioma ; Humans ; Neoplasm, Residual