1. Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial
Morteza SHAKHSI NIAEE ; Fatemeh CHERAGHI ; Peyman NAMDAR ; Abbas ALLAMI ; Amin KARAMPOUR ; Leila ZOLGHADR ; Amir JAVADI ; Mehran VARNASERI ; Masoumeh KARAMYAN ; Mohammad YADYAD ; Ramin JAMSHIDIAN ; Behzad BIJANI ; Yazdan NADERI ; Nematollah GHEIBI ; Fatemeh AMINI
Asian Pacific Journal of Tropical Medicine 2021;14(6):266-273
Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical consequences. Methods: A randomized, double-blind, placebo-controlled, multicenter clinical trial was performed at five hospitals. A total of 180 mild hospitalized patients with COVID-19 confirmed by PCR or chest image tests were enrolled and allocated to six arms including hydroxychloroquine 200 mg twice per day, placebo plus hydroxychloroquine 200 mg twice per day, single dose ivermectin (200 μg/kg), three low interval doses of ivermectin (200, 200, 200 μg/kg), single dose ivermectin (400 μg/kg), and three high interval doses of ivermectin (400, 200, 200 μg/kg). The primary endpoint of this trial was all-cause of mortality or clinical recovery. The radiographic findings, hospitalization and low O
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