Objective To explore the impact of individualized care on fatigue and quality of life in lung cancer patients after chemotherapy. Methods A total of 80 lung cancer patients in our hospital from August 2012 to November 2013 were selected as research subjects, and they were averagely divided into observation group and control group by the method of simple random sampling. Two groups of patients treated with conventional care in the process of conventional chemotherapy and symptomatic treatment, but the observation group were treated with individualized care for the different situation of each patient on the basic of conventional care. The fatigue, sleeping condition and quality of life had been evaluated by BFI, PSQI and EORCT QLQ-30 before and after intervention. Results Before treatment, there were no significant differences between two groups in fatigue, sleep conditions and quality of life (P>0. 05). After six weeks of nursing intervention, the patients with severe fatigue were 12 in the observation group compared with 20 in the control group (Z=1. 859, P<0. 05). The scores of PSQI and quality of life in the observation group gained better results than these in the control group (11 cases vs 21 cases)(χ2 =5. 208,P<0. 05) and (17. 6 ± 5. 6 vs 12. 6 ± 4. 8)(t=4. 287,P<0. 01). Conclusions The Individualized care, as a comprehensive care, can relieve fatigue, improve the sleep situation and quality of life to the greatest extent.