1.Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting.
Qun YANG ; Xiaoxin LIU ; Yuna JIANG ; Jinan MA
Journal of Southern Medical University 2023;43(6):1017-1022
OBJECTIVE:
To investigate the correlation between aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphisms and chemotherapy-induced nausea and vomiting (CINV).
METHODS:
A total of 90 Chinese patients with malignant tumors receiving chemotherapy for the first time were recruited in this study. The occurrence of CINV was observed within 120 h after treatment with docetaxel and cis-platinum chemotherapy (DP regimen). The data of the patients (including age, gender, tumor stage, habitual alcohol consumption, motion sickness, morning sickness, and average sleep time prior to chemotherapy) were collected through a questionnaire. ALDH2 rs671 polymorphisms of the patients were analyzed using a multiple single nucleotide polymorphism genotyping, and the Hardy-Weinberg equation was used for genetic linkage analysis. The correlations between the factors including ALDH2 rs671 polymorphisms and the occurrence of CINV were analyzed.
RESULTS:
The incidence of CINV was 48.9% among the patients receiving their first chemotherapy with DP regimen. Univariate analysis indicated that the genetic polymorphisms of ALDH2 rs671 were significantly correlated with the occurrence of CINV (P < 0.05). Multivariate logistic analysis indicated that ALDH2 rs671 mutation (OR: 3.019, 95% CI: 1.056-8.628, P < 0.05) and average sleep time prior to chemotherapy no longer than 6 h (OR: 2.807, 95% CI: 1.033-7.628, P < 0.05) were risk factors for CINV in patients with malignant tumors receiving the first chemotherapy with DP regimen.
CONCLUSION
ALDH2 gene mutation at rs671 is a risk factor contributing to the occurrence of CINV, and understanding of the underlying mechanism may help to more effectively control the occurrence of CINV.
Humans
;
Aldehyde Dehydrogenase, Mitochondrial/genetics*
;
Antineoplastic Agents/adverse effects*
;
Nausea/genetics*
;
Polymorphism, Single Nucleotide
;
Vomiting/genetics*
;
Neoplasms/drug therapy*
2.Hereditary hemorrhagic telangiectasia: a rare cause of long-lasting abdominal distension in an 8-year-old boy.
Leiling CHEN ; Shiming LANG ; Tingze HU ; Lin ZHONG ; Junjie LI
Chinese Medical Journal 2002;115(4):620-621
Abdomen, Acute
;
etiology
;
Child
;
Family Health
;
Female
;
Gastrointestinal Diseases
;
etiology
;
Genes, Dominant
;
genetics
;
Humans
;
Male
;
Nausea
;
etiology
;
Pedigree
;
Telangiectasia, Hereditary Hemorrhagic
;
complications
;
genetics
;
pathology
;
Time Factors
;
Vomiting
;
etiology
3.Association of 5-HT3B Receptor Gene Polymorphisms with the Efficacy of Ondansetron for Postoperative Nausea and Vomiting.
Min Soo KIM ; Jeong Rim LEE ; Eun Mi CHOI ; Eun Ho KIM ; Seung Ho CHOI
Yonsei Medical Journal 2015;56(5):1415-1420
PURPOSE: Postoperative nausea and vomiting (PONV) is a common problem after general anesthesia. Although 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists have significantly reduced PONV, over 35% of patients treated with ondansetron can experience PONV. In this study, we investigated whether the Y129S and -100_-102AAG deletion polymorphisms of the 5-HT3B receptor gene affect the efficacy of ondansetron in preventing PONV. MATERIALS AND METHODS: Two hundred and forty-five adult patients who underwent laparoscopic cholecystectomy were enrolled. Ondansetron 0.1 mg/kg was intravenously administered 30 minutes before the end of surgery. Genomic DNA was prepared from blood samples using a nucleic acid isolation device. Both the Y129S variant and the -100_-102AAG deletion variant were screened for using a single base primer extension assay and a DNA direct sequencing method, respectively. The relationship between genetic polymorphisms and clinical outcomes of ondansetron treatment was investigated. RESULTS: Among the 5-HT3B AAG deletion genotypes, the incidence of PONV was higher in patients with the homomutant than with other genotypes during the first 2 hours after surgery (p=0.02). There were no significant differences in the incidence of PONV among genotypes at 2-24 hours after surgery. In the Y129S variants of the 5-HT3B receptor gene, there were no significant differences in the incidence of PONV among genotypes during the first 2 hours and at 2-24 hours after surgery. CONCLUSION: The response to ondansetron for PONV was significantly influenced by the -100_-102AAG deletion polymorphisms of the 5-HT3B gene. Thus, the -100_-102AAG deletion variants may be a pharmacogenetic predictor for responsiveness to ondansetron for PONV.
Adult
;
Aged
;
Anesthesia, General
;
Antiemetics/administration & dosage/*pharmacology
;
Cholecystectomy, Laparoscopic
;
Female
;
Genome, Human
;
Genotype
;
Humans
;
Incidence
;
Injections, Intravenous
;
Male
;
Middle Aged
;
Ondansetron/administration & dosage/*pharmacology
;
Polymorphism, Genetic
;
Postoperative Nausea and Vomiting/chemically induced/*drug therapy/epidemiology
;
Receptors, Serotonin, 5-HT3/*drug effects/*genetics
;
Time Factors
4.Effects of micro-Opioid Receptor Gene Polymorphism on Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia with Remifentanil: Double Blinded Randomized Trial.
Seung Hyun LEE ; Joo Dong KIM ; Sol Ah PARK ; Chung Sik OH ; Seong Hyop KIM
Journal of Korean Medical Science 2015;30(5):651-657
Association between postoperative nausea and vomiting (PONV) and micro-opioid receptor A118G single nucleotide polymorphism (SNP) is undefined and might underlie inconsistent results of studies on PONV occurrence in patients undergoing general anesthesia with the opioid, remifentanil. Four hundred and sixteen Korean women undergoing breast surgery with general anesthesia were randomized to receive remifentanil 10 ng/mL (plasma-site, Minto model) using a target-controlled infusion device and either propofol for total intravenous anesthesia (T group) or sevoflurane for inhalation anesthesia (I group) with bispectral index values maintained between 40 and 60. Blood specimens were collected after anesthesia induction for A118G SNP analysis. PONV and postoperative pain were evaluated. A118G SNP type distribution among Korean female adults studied was AG (n=195)>AA (n=158)>GG (n=63). Regardless of anesthetic technique, patients with GG types had lower PONV scale on arrival at postoperative care unit (PACU) (P=0.002), while T group showed lower PONV scale than I group up to 6 hr after PACU discharge in AA and AG types. No differences were apparent for postoperative pain among opioid receptor polymorphism. PONV occurrence differs according to opioid receptor polymorphism and anesthetic technique in patients undergoing general anesthesia with remifentanil.
Adult
;
Analgesics, Opioid/*adverse effects
;
Anesthesia, General/*adverse effects
;
Breast Diseases/surgery
;
Demography
;
Double-Blind Method
;
Female
;
Humans
;
Methyl Ethers/adverse effects/therapeutic use
;
Pain, Postoperative/drug therapy
;
Piperidines/*adverse effects/therapeutic use
;
*Polymorphism, Single Nucleotide
;
Postoperative Nausea and Vomiting/*etiology
;
Receptors, Opioid, mu/*genetics