Carcinoma, Neuroendocrine ; pathology ; Humans ; Nasal Cavity ; pathology ; Nasopharynx ; pathology

Adult ; Female ; Hamartoma ; Humans ; Nasopharyngeal Diseases ; Nasopharynx ; pathology

Humans ; Male ; Melanins ; metabolism ; Metaplasia ; metabolism ; pathology ; Middle Aged ; Nasopharyngeal Diseases ; metabolism ; pathology ; Nasopharynx ; metabolism ; pathology

Amyloidosis ; pathology ; Humans ; Laryngeal Diseases ; etiology ; Larynx ; pathology ; Male ; Middle Aged ; Nasopharynx ; pathology

Bronchiolitis ; diagnosis ; microbiology ; pathology ; Female ; Humans ; Infant ; Leukotriene D4 ; analysis ; Male ; Nasopharynx ; chemistry ; microbiology ; pathology

Inflammatory myofibroblastic tumor （IMT） is a rare mesenchymal soft tissue tumor characterized by borderline or low-grade malignancy. It is rare childhood tumor with an average age of onset of 10 years old. It is even rarer in infants and toddlers, and the etiology and pathogenesis of this tumor are still unclear. The clinical presentation of IMT is non-specific and are related to the location of the tumor. When the tumor compresses adjacent organs, it can cause pain and functional impairment. According to the current literature, IMT is most commonly found in the digestive and respiratory systems, but also occasionally occur in the genitourinary system, head and neck, and limbs. At present, there have been no reports of nasopharyngeal IMT involving nasal cavity of infants and toddlers at home and abroad.This article reports a case of a massive inflammatory myofibroblastic tumor involving the nasal cavity and nasopharynx in an infant. Plasma-assisted minimally invasive surgery was performed through multiple surgical approaches and achieved satisfactory therapeutic results. This case report may provide valuable reference for the treatment of similar diseases.
Humans ; Infant ; Granuloma, Plasma Cell/pathology* ; Nasopharynx/pathology* ; Neoplasms, Muscle Tissue ; Soft Tissue Neoplasms

Adult ; Choristoma ; Female ; Humans ; Nasopharynx ; pathology ; Paranasal Sinus Diseases ; Pituitary Neoplasms ; Sphenoid Sinus ; pathology

Adenoid hypertrophy is a disease that mostly occurs among children of 3-5 years old. It is caused by repeated inflammation and infection of nasopharynx and its adjoin parts, or the adenoid itself, which will finally leads to pathological hyperplasia of adenoid. With so much information we have acquired about this disease, its specific mechanism remains unknown. In recent years, some researches have indicated that adenoid hypertrophy may have something to do with extra-gastroesophageal reflux, in which pepsin plays a very important role, and pepsin will do a series of pathological damages to the upper airway as it reaches the upper respiratory tract. Based on relative domestic and foreign literature, this paper attempts to make a review about the relationship between gastroesophageal reflux and adenoid hypertrophy.
Adenoids ; pathology ; Child ; Gastroesophageal Reflux ; complications ; Humans ; Hypertrophy ; complications ; Nasopharynx ; pathology ; Pepsin A ; metabolism

OBJECTIVE: To investigate the clinicopathological features, diagnosis and treatment of giant cell granuloma outside the jaw. METHOD: The clinical and pathological datas of 3 cases in nasopharynx, temporal bone and maxillary sinus were analyzed retrospectively. The relevant literatures were also reviewed. RESULT: The patients presented with local painless mass, part of which were aggressive. Histopathological feature was, replacement of the normal bone structure with proliferating fibrous tissue containing numerous giant cells was shown. CONCLUSION Giant cell granuloma outside the jaw was a non-neoplastic lesion, and extremely rare. It was somewhat difficult to make a correct diagnosis. Combining the clinical data and pathological feature were more helpful to the diagnosis. Total surgical resection was an effective therapeutic method.
Adolescent ; Adult ; Female ; Granuloma, Giant Cell ; pathology ; Humans ; Jaw ; Male ; Maxillary Sinus ; pathology ; Nasopharynx ; pathology ; Temporal Bone ; pathology ; Young Adult

Adolescent ; Child ; Cleft Palate ; pathology ; Eustachian Tube ; anatomy & histology ; pathology ; Female ; Humans ; Male ; Nasopharynx ; anatomy & histology ; pathology ; Young Adult