Studying the dynamy of immunobiological parameters after radiotherapy and estimating its prognostic values on 77 NPC patients with T1-3No-3Mo (UICC 1979) at Hanoi K hospital from 11/1994 to 12/1998. We have some results: The prognostic values have been found significantly in the quantity of leukocytes, the level of serum IgA/VCA, IgG/EBNA before radiotherapy, the frequency of HLA antigens A11, A2, B17 and the desequilibre linkage A11-B17, A2-B17. Especially, the increase of serum IgA/VCA after radiotherapy has significantly predicted recurrence of studied NPC patients
Nasopharyngeal Neoplasms ; Nasopharyngeal Diseases ; Radiotherapy

By the technique of indirect immunofluoresceine using 18 diverse markers, in the hospital K- Ha Noi, study was performed to determine the capacity of foreign antigene expression of tumor cells in the cell surface making them identified by immunology system through HLA system on NPC < 75 years old age patients. This system played an essential role in the regulation and realization of immune response.
Carcinoma ; Nasopharyngeal Neoplasms ; Nasopharyngeal Diseases ; Diagnosis

In order to investigate the changes of some cytokines in NPC patients, we have made an measure of IL-2 and IL-10 in cell culture supernatants on 22 NPC patients, at II, III, IVa, IVb stage, positive anapathological test, compare with 12 healthy age-matched controls. The obtained results showed that: IL-2 production was significantly depressed in cell culture supernatants of NPC patients compare with control group. The production of IL-10 was increased in cell culture supernatants of NPC patients at late stages. It suggested that, IL-10 may be an prognostic factor in severe NPC patients and may prove valuable in selecting with NPC who are candidates for aggressive therapy
Nasopharyngeal Neoplasms ; Nasopharyngeal Diseases ; Cell Culture Techniques ; Culture

Nasopharyngeal Neoplasms ; Carcinoma ; Lymph Nodes ; Asymptomatic Diseases

Low grade nasopharyngeal papillary adenocarcinoma (LGNPPA) is an extremely rare variant of nasopharyngeal cancer, which exhibits distinct clinicopathological characteristics. Surgical resection has been regarded as the principal treatment. For this, transpalatal or transfacial approach has been classically used for exposure of the field. Up for now, there has been no report on applying endoscopic approach for this disease, which could be an effective alternative to minimize possible morbidities of palatotomy or maxillotomy. Endoscopic approach can be justified considering narrow extent and indolent behavior of LGNPPA. We report a patient with LGNPPA, which was successfully resected exclusively by endoscopic visualization. Our case exhibited narrow-based exophytic features with compatible immunopathologic profiles of LGNPPA. Exclusive endoscopic resection can be effective and less-morbid modality for this rare disease as in this case.
Adenocarcinoma, Papillary ; Endoscopy ; Humans ; Immunohistochemistry ; Nasopharyngeal Neoplasms ; Rare Diseases

Objective:To compare the clinical effects and complications of surgery + chemotherapy and radiotherapy + chemotherapy in patients with nasopharyngeal carcinoma recurrence, so as to compare the safety and efficacy of two different therapeutic methods. Methods:A retrospective analysis was performed on 40 patients with recurrent nasopharyngeal carcinoma after radiotherapy and chemotherapy admitted to our hospital from January 2016 to June 2020. Among them, 26 patients were treated with surgery. The recurrent tumor was removed under nasal endoscope, and the frozen resection margin was negative during the operation. Chemotherapy was continued for stage Ⅲ and Ⅳ patients from 3 to 5 weeks after surgery. Fourteen patients received secondary radiotherapy and chemotherapy. Postoperative complications and survival rate were observed. Results:There were 14 patients in the secondary chemoradiotherapy group（control group） and 26 patients in the nasal endoscopic surgery group（observation group）. Among the 26 patients, 19 patients underwent nasal septal mucosal repair, 5 patients underwent temporal muscle flap repair, 2 patients underwent submental flap repair, 2 patients had nasal septal mucosal flap necrosis and cerebrospinal fluid leakage, and the temporal muscle flap was used for secondary repair in the second stage operation, and 8 patients needed cervical lymph node dissection. The patients recovered well after surgery, and the patients in stage Ⅲ and Ⅳ were treated with chemotherapy after 3 weeks to 5 weeks according to the patient's wound condition. There were significant differences in the incidence of complications and 1-, 2-, and 3-year survival rates between the two groups（P<0.05）. Conclusion:Patients with recurrent nasopharyngeal carcinoma can be treated by nasal endoscopic surgery to remove the tumor, and the use of pedicled nasal septal mucosal flap or temporal muscle flap for skull base reconstruction, The operation can effectively prevent major complications such as internal carotid artery rupture and hemorrhage, and improve the survival rate and quality of life of patients. It provides a safe and effective treatment for patients with recurrent nasopharyngeal carcinoma.
Humans ; Plastic Surgery Procedures ; Nasopharyngeal Carcinoma/surgery* ; Retrospective Studies ; Quality of Life ; Skull Base/surgery* ; Nose Diseases/pathology* ; Nasopharyngeal Neoplasms/pathology*

BACKGROUND AND OBJECTIVES: The nasopharyngeal cancer (NPC) of nasopharyngeal neoplasms is a rare disease with a relatively poor prognosis, because they tend to be diagnosed in the far advanced stage. Therefore, radiotherapy had been the treatment of choice. Angiogenesis is a crucial step in the tumor growth and progression. The authors attempted to investigate the prognostic value of the microvessel density in NPC. SUBJECTS AND METHOD: We analyzed tumor tissues from 57 cases of paraffin block specimens which had been diagnosed with NPC and treated at Chonnam National University Hospital. The anti-human von Willebrand factor antibody was used to determine the microvessel density (MVD). RESULTS: The MVD was 48.5 in the early stage (stage I and II) and 51.2 in the advanced stage (stage III and IV), which were not statistically significant (p=0.057). The MVD was 55.3 in type I, 54.4 in type II, and 41.8 in type III, and there were no statistical significance between these values (p=0.36). The MVD was not statistically significant between T and N stages (p=0.26, 0.42). There was no significance between the MVD and the survival rates (p>0.05). CONCLUSION: The results suggest that the MVD was not a prognostic significance in NPC.
Jeollanam-do ; Microvessels* ; Nasopharyngeal Neoplasms ; Paraffin ; Prognosis ; Radiotherapy ; Rare Diseases ; Survival Rate ; von Willebrand Factor

Abscess ; diagnosis ; Diagnostic Errors ; Female ; Humans ; Middle Aged ; Nasopharyngeal Neoplasms ; diagnosis ; Pharyngeal Diseases ; diagnosis

OBJECTIVE: To observe the effect of hypothermia plasma radiofrequency ablation to the adhesion of nasal cavity after radiotherapy of nasopharyngeal carcinoma. METHOD: The subjective score combined with nasal ventilation function test were used to reflect the degree of patients with nasal adhesion. RESULT: There is a significant improvement in subjective feeling after treatment. Nasal cavity volume began to increase and nasal expiratory resistance decrease obviously 3M later. CONCLUSION Hypothermia plasma radiofrequency ablation technology can improve the nasal cavity adhesion in patients with nasopharyngeal carcinoma after radiotherapy, and also the patients quality of life.
Carcinoma ; Catheter Ablation ; methods ; Female ; Humans ; Hypothermia, Induced ; Male ; Nasal Cavity ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms ; radiotherapy ; Nose ; Nose Diseases ; surgery ; Quality of Life ; Tissue Adhesions ; surgery

Aneurysm, False ; etiology ; surgery ; Blood Loss, Surgical ; Carcinoma ; Carotid Arteries ; Carotid Artery Diseases ; etiology ; surgery ; Humans ; Nasopharyngeal Neoplasms ; radiotherapy ; Rupture