1.Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19.
Lunzhi YUAN ; Huachen ZHU ; Ming ZHOU ; Jian MA ; Rirong CHEN ; Liuqin YU ; Wenjia CHEN ; Wenshan HONG ; Jia WANG ; Yao CHEN ; Kun WU ; Wangheng HOU ; Yali ZHANG ; Shengxiang GE ; Yixin CHEN ; Quan YUAN ; Qiyi TANG ; Tong CHENG ; Yi GUAN ; Ningshao XIA
Protein & Cell 2022;13(1):72-77
Animals
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Antibodies, Neutralizing/biosynthesis*
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Antibodies, Viral/biosynthesis*
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Body Weight/immunology*
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COVID-19/virology*
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Disease Models, Animal
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Disease Progression
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Humans
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Immunohistochemistry
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Lung/virology*
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Male
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Mesocricetus
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Nasal Cavity/virology*
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RNA, Viral/immunology*
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SARS-CoV-2/pathogenicity*
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Severity of Illness Index
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Viral Load
2.Epstein-Barr virus positive anaplastic-like plasmacytoma: report of a case.
Wen-sheng LI ; Xiao-ge ZHOU ; Jian-lan XIE
Chinese Journal of Pathology 2013;42(3):203-204
ADP-ribosyl Cyclase 1
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metabolism
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Aged
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Epstein-Barr Virus Infections
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Herpesvirus 4, Human
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isolation & purification
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Humans
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Interferon Regulatory Factors
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metabolism
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Ki-67 Antigen
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metabolism
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Male
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Nasal Cavity
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Nose Neoplasms
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metabolism
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pathology
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surgery
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virology
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Plasmacytoma
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metabolism
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pathology
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surgery
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virology
3.Nasal and pharyngeal non-Hodgkin lymphomas and their relationship with Epstein-Barr virus: a report of 158 cases.
Yan-Jiao HE ; Xin-Shan JIA ; Kazuhisa HASUI ; En-Hua WANG ; An-Guang HE
Chinese Journal of Pathology 2007;36(2):94-97
OBJECTIVETo study the clinical features, immunophenotypes and the significance of Epstein-Barr virus infection in primary nasal and pharyngeal non-Hodgkin's lymphomas in Shenyang.
METHODSOne hundred and fifty eight cases of primary nasal and pharyngeal non-Hodgkin's lymphomas were included in this study. The samples were stained with haematoxylin and eosin for histological examination. Immunohistochemistry studies were performed using monoclonal antibodies, including CD3 for T-lymphocytes, CD20 for B-lymphocytes, and CD56 and CD57 for NK cells. All cases were reclassified according to the new WHO classification of lymphomas (2001). In situ hybridization detection of EBV-encoded small nuclear RNA (EBER-1) was performed in 99 cases.
RESULTSOverall, 101 (63.9%) of the 158 NHL were extranodal NK/T cell lymphomas (nasal type), 23 (14.6%) were nonspecific peripheral T cell lymphomas and the remaining 34 cases (21.5%) were B cell lymphomas. The primary sites of involvement were the nasal cavity (53.2%, 84/158), the tonsil (24.7%, 39/158) and the pharynx (22.1%, 35/158). Among 99 cases studied by EBER-1 in situ hybridization, a positive detection was seen in 70/71 cases (98.6%) of extranodal NK/T cell lymphoma (nasal type), 8/12 cases (66.7%) of T cell lymphoma, and 7/16 cases (43.8%) of B cell lymphoma.
CONCLUSIONSAmong primary nasal and pharyngeal NK lymphomas, extranodal NK/T cell lymphoma (nasal type) is the most common type and is strongly associated with EBV infection. The pathological diagnosis of nasal and pharyngeal lymphomas should take considerations of the anatomic sites and immunophenotypical features.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; CD3 Complex ; metabolism ; CD56 Antigen ; metabolism ; Child ; Female ; Herpesvirus 4, Human ; isolation & purification ; Humans ; Lymphoma, B-Cell ; metabolism ; pathology ; virology ; Lymphoma, Extranodal NK-T-Cell ; metabolism ; pathology ; virology ; Lymphoma, Non-Hodgkin ; metabolism ; pathology ; virology ; Lymphoma, T-Cell, Peripheral ; metabolism ; pathology ; virology ; Male ; Middle Aged ; Nasal Cavity ; Nose Neoplasms ; metabolism ; pathology ; virology ; Pharyngeal Neoplasms ; metabolism ; pathology ; virology ; RNA, Viral ; metabolism ; Tonsillar Neoplasms ; metabolism ; pathology ; virology ; Young Adult
4.Bone Marrow is Involved in Less than 10% of Patients with Nasal-Type NK/T Cell Lymphoma at Initial Diagnosis.
Chang Okh SUNG ; Young Hyeh KO
Journal of Korean Medical Science 2004;19(2):229-233
To evaluate the frequency of bone marrow involvement by nasal-type NK/T cell lymphoma, we retrospectively studied biopsy specimens from 40 patients by EBV in situ hybridization (ISH). Three patients had marrow involvement at initial diagnosis (7.5%). In one patient (1/40, 2.5%), the disease in bone marrow was recognized by routine morphological assessment, while two other patients had minimal involvement of lymphoma cells which was recognized only by EBV in situ hybridization (2/40, 5%). Two patients had a disseminated disease at diagnosis and died 6 days and 214 days after diagnosis. One patient had diffuse colonic lesion and died 82 days later. In conclusion, marrow involvement in nasal NK/T cell lymphoma is infrequent at initial diagnosis, and EBV ISH is a useful technique for identifying the minor subgroup of patients which have easily overlooked neoplastic involvement.
Adult
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Aged
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Aged, 80 and over
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Biopsy
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Bone Marrow/*pathology
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Epstein-Barr Virus Infections/complications/pathology
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Female
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Herpesvirus 4, Human/genetics
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Human
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Killer Cells, Natural/*pathology
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Lymphoma, T-Cell/complications/*pathology
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Male
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Middle Aged
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Nasal Cavity/*pathology/virology
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Prognosis
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RNA, Viral/analysis
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Retrospective Studies