Objective To investigate the status quo of specific psychological reaction in patients with cervical intraepithelial neoplasia and to analyze its influencing factors.Methods A total of 243 patients with cervical intraepithelial neoplasia selected by simple random sampling were investigated with the general data questionnaire and process outcome specific measure (POSM).Results The score of the Chinese version of the POSM was (34.60±7.464) with high scores in worrying about family planning, sexual life, cancerization and health. There were statistically significant differences in the scores of POSM among patients with different ages, ways of medical payments, marital status, and whether they had kids and diseases (P<0.05). The multiple linear regression showed that ages and disease classification were the main influencing factors of the level of specific psychological reaction of patients.Conclusions Patients with cervical intraepithelial neoplasia are with specific psychological reaction. Nursing staff in clinical nursing should pay attention to mental status in young and low grade patients with cervical intraepithelial neoplasia, provide specific nursing intervention and promote physical and mental health of patients.