Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by the presence of eosinophilic nuclear inclusions in neurons and somatic cells. It clinically manifests as cognitive decline, seizures, and autonomic dysfunction. A 44-year-old man presented with a transient visual field defect and hemiparesis. Based on characteristic imaging findings and pathological findings, NIID was suspected and diagnosed through genetic testing. This case emphasizes the importance of comprehensive clinical phenotype analysis and accurate genetic diagnosis.

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by the presence of eosinophilic nuclear inclusions in neurons and somatic cells. It clinically manifests as cognitive decline, seizures, and autonomic dysfunction. A 44-year-old man presented with a transient visual field defect and hemiparesis. Based on characteristic imaging findings and pathological findings, NIID was suspected and diagnosed through genetic testing. This case emphasizes the importance of comprehensive clinical phenotype analysis and accurate genetic diagnosis.

Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by the presence of eosinophilic nuclear inclusions in neurons and somatic cells. It clinically manifests as cognitive decline, seizures, and autonomic dysfunction. A 44-year-old man presented with a transient visual field defect and hemiparesis. Based on characteristic imaging findings and pathological findings, NIID was suspected and diagnosed through genetic testing. This case emphasizes the importance of comprehensive clinical phenotype analysis and accurate genetic diagnosis.

Background and objectives: The number of workers taking temporary leave due to clinical depression is increasing, and the probability that these workers will take such leave again after returning to work is high. In response to this dilemma, institutions involved in psychiatric care across Japan now implement “rework programmes,” aiming to help employees resume work without relapsing to depression. Methods: This programme has several forms. Between May 2017 and June 2019, 32 patients on temporary leave due to a depressed mood participated in group psychotherapy at our clinic. Of these patients, 21 patients who were able to return to work without a recurrence of symptoms, evaluated upon reinstatement, and followed up for 1 year were analysed in this study. The participants were divided into two groups: a continued employment group (n=16) consisting of patients who were still working one year after reinstatement and a repeat leave group (n=5) consisting of those who took temporary leave again within the first year. Differences in psychiatric symptoms, social function, cognitive function, readiness to return to work, and other factors were compared between the two groups. Results: The continued employment group was likely to have better social function, cognitive flexibility, and executive function when returning to work. Conclusion These preliminary results indicate that social functions and cognitive functions might be associated with continued employment.