From the perspective of complementary and alternative medicine, we searched for human clinical research reports on functional foods and nutrients that aimed at maintaining and improving brain function. Specifically, we comprehensively investigated the clinical reports that examined the efficacy of functional ingredients in terms of the maintenance and improvement of brain function, memory, and cognition in healthy individuals. Moreover, we examined the summary of intervention and test results of articles extracted from the Ichushi-Web and J Dream III databases.

We comprehensively investigated the clinical reports that examined the efficacy of functional ingredients in healthy individuals. As a result, of the 25 literature articles ultimately reviewed, one intervention trial each on reduced coenzyme Q10, black soybean seeds, inulin, rosemary extract, theanine, fermented ginseng, arctigenin, sulforaphane, curcumin and Vitamin E, tongkat ali, Apocynum venetum Leaf Extract, matured Red ginseng txtract, hotrienol, vitamin C, soy protein enzyme hydrolysate, 3,5-dihydroxy-4-methoxybenzyl alcohol, chlorogenic acid, succulent plant caralluma fimbriata extract, and L-ornithine, two on fish oil, two on citric acid, and two on enzyme-treated asparagus extract were reported.