1.Effects of a Mouthwash Containing Plant Extracts on Gingivitis and Halitosis
Koji HATTORI ; Akiko WATANABE ; Hiroshi TAKAGI ; Naokazu HOTTA ; Youichi YASHIRO ; Ryoma GOTO ; Noritaka SAWADA ; Genta YAMAMOTO ; Akio MITANI ; Seiji HASEGAWA
Japanese Journal of Complementary and Alternative Medicine 2023;20(1):1-8
Mouthwash is used to support brushing because it is distributed throughout the oral cavity. In this study, we examined the efficacy of a mixture of three hot water extracts (from Hordeum vulgare L, Apocynum venetum L, and Brasenia schreberi J. F. Gmel) for the purpose of developing an effective mouthwash. The mixture suppressed enhanced tumor necrosis factor α and matrix metalloproteinase 3 gene expression by Porphyromonas gingivalis lipopolysaccharide stimulation in human gingival fibroblasts. Furthermore, human studies using a mouthwash containing the plant extracts (MW) improved gingival index and bleeding on probing in the gum, and reduced the concentration of methyl mercaptan, which causes bad breath, in the mouth. These findings suggest that continued use of MW has positive effects on gingival inflammation and halitosis, and is useful for maintaining oral health.
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