1.Significance of Combined Use of Kamishoyosan and Tokishakuyakusan for General Infertility Treatment
Takeshi NAKAYAMA ; Fumiko TAWARA ; Nao MURABAYASHI ; Shuhei SO ; Wakasa YAMAGUCHI ; Naomi MIYANO ; Kensuke UETA ; Kyoko SUZUKI ; Yoshimasa HORIKOSHI ; Rui KOIZUMI ; Aki MUKAI ; Naoaki TAMURA ; Hiroaki ITOH ; Naohiro KANAYAMA
Kampo Medicine 2021;72(4):361-367
We aimed to clarify the significance of using Kampo therapy centered on kamishoyosan and tokishakuyakusan together with general infertility treatment. The subjects were 41 women who visited a Kampo outpatient clinic for infertility and received general infertility treatment with Kampo therapy (Kampo group). The control group was 781 women who received only general infertility treatment at the same time (non-Kampo group). In comparing both groups, we conducted a retrospective survey on the pregnancy rate by cycle and the pregnancy rate by prescription. The pregnancy rate in the first cycle was 24.4% in the Kampo group and 8.5% in the non-Kampo group, and the pregnancy rate was higher in the Kampo group (P = 0.003). There was no difference in pregnancy rates after the second cycle. The pregnancy rate by prescription was 26.7% for kamishoyosan, 22.2% for tokishakuyakusan, and 8.5% for the non-Kampo group. In the comparison between the first cycle pregnant group and the non-pregnant group, the qi counter flow score was clearly higher in the first cycle pregnant group (P = 0.012). It is suggested that combined use of Kampo therapy including kamishoyosan and tokishakuyakusan may be effective from an early stage. Meanwhile, if pregnancy does not occur even after the combined use of Kamp therapy, it would be an opportunity to consider stepping up as Western medical therapy.
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