1.A Case of Subdural Empyema Complicating Hemophilus Influenzae Meningitis.
Myung Sun OH ; Nan Kyung KIM ; Sae Yoo JUNG ; Soon Ung KANG ; Jung Kyou KIM ; Byong Kwan SON
Journal of the Korean Pediatric Society 1990;33(8):1128-1132
No abstract available.
Empyema, Subdural*
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Haemophilus influenzae*
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Haemophilus*
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Meningitis*
2.Ito Cell Activity and Hepatocyte Proliferation Activity According to Collagen Content in Liver Cirrhosis.
Kee Taek JANG ; Young Mi JUNG ; In Kyoung LIM ; Yun Sil LEE ; Nan Kyung MYUNG ; Mi Ran KIM ; Min Jae LEE ; Ja June JANG
The Korean Journal of Hepatology 1998;4(3):254-263
BACKGROUND/AIMS: Liver cirrhosis is an end-stage liver disease. Ito cell is known to have central role in fibrogenes is of liver cirrhosis. But collagen content and Ito cell activity in liver cirr hosis have received little attention. So Ito cell activity and hepatocyte proliferation activity according to collagen content was investigated. WAF-1 and c- met were studied to evaluate the effect of cell cycle. METHODS: We analyzed 56 cases of liver cirrhosis ( viral:41, biliary:11, alcoholic:2, Wilson' s disease:2). Collagen content was measured by spectrophot ometry. Ito cell activity and prolifer ation index was measured by-SMA and Ki- 67 immunohistochemistry. RESULTS: In viral cirrhosis, high collagen group showed increased Ito cell activity compared to low collagen group. There was no difference in hepatocyte prolifer ation activity bet ween high and low collagen group in viral cirrhosis. In biliary cirrhos is, high collagen group showed increased Ito cell activity in septal zones compared to low collagen group. WAF- 1and c- met were negative in most of cases. CONCLUSION: Collagen content of liver cirrhosis is closely related to increment of activated Ito cells . Ito cell activity was prominent in septal zones than in parenchymal areas of viral cirrhosis and that was only significant in septal zones of biliary cirrhosis. There is no correlation bet ween collagen content and hepatocyte proliferation activity.
Cell Cycle
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Collagen*
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Fibrosis
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Hepatic Stellate Cells
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Hepatocytes*
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Immunohistochemistry
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Liver Cirrhosis*
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Liver Cirrhosis, Biliary
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Liver Diseases
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Liver*
3.The Validity of Nursing Diagnosis in Rehabilitation Nursing.
Hyun Sook KANG ; Nan Young LIM ; Moon Ja SUH ; Kuem Soon KIM ; Kwang Hee YANG ; Myung Hwa LEE ; Bok Hee CHO ; Hye Kyung OH
Korean Journal of Rehabilitation Nursing 1999;2(1):45-60
This study was conducted to investigate the nursing diagnosis applying to rehabilitation unit. The subject of this was consisted of 101 nurses who have been working over 1 year in rehabilitation unit. The clssification of nursing diag-nosis used NANDA's system and analysis of the validity was based on Fehring's model. In summury of this study, some dirrerences were found in related factors in nursing diagnosis between rehabilitation and general unit. Major re-lated factors of nursing diagnosis were physical factors associated with neuromuscular disorder. Valid related factors in altered nutrition: more than body requirements was not found for re-habitation unit. It is helpful for the nurses who work at re-habilitation unit to apply the nursing diagnosis validated in this study. This finding can be used as the database for accomplished nursing diag-nosis appropriate for improving the rehabilitation nursing practice.
Nursing Diagnosis*
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Nursing*
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Rehabilitation Nursing*
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Rehabilitation*
4.Investigation of Espoused Theories in Nursing Practice.
Moon Ja SUH ; Hae Sook KIM ; Eun Hee LEE ; Young Sook PARK ; Kyung Sook CHO ; Hyun Sook KANG ; Nan Young IM ; Joo Hyun KIM ; So Woo LEE ; Bok Hee CHO ; Myung Hwa LEE ; Sung Ai CHI ; Yang Sook HAH ; Young Hee SON ; Sung Bok KWON ; Hee Jin KIM ; Jin A CHOO
Journal of Korean Academy of Adult Nursing 2001;13(1):53-69
As a nursing practice involves nurses'actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives. Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal); excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, accountability and commitment(4 theories of nursing ethics); human respect, partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences, positive perspectives(4 theories of nurse), role of intervention, rewarding, peer relationship(3 theories of situations). The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore, it is recommended to review the theories-in-use in order to find any discrepancies between the espoused theories and the reality of nursing actions.
Data Collection
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Delivery of Health Care
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Education, Nursing
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Humans
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Nursing*
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Reward
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Social Responsibility
5.Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model
Dae Sung PARK ; Seok OH ; Yu Jeong JIN ; Mi Hyang NA ; Munki KIM ; Jeong Ha KIM ; Dae Young HYUN ; Kyung Hoon CHO ; Young Joon HONG ; Ju Han KIM ; Youngkeun AHN ; Manuel HERMIDA-PRIETO ; José Manuel VÁZQUEZ-RODRIGUEZ ; Juan Luis GUTIÉRREZ- CHICO ; Luis MARINÃS-PARDO ; Kyung Seob LIM ; Jun-Kyu PARK ; Dae-Heung BYEON ; Young-Nan CHO ; Seung-Jung KEE ; Doo Sun SIM ; Myung Ho JEONG
Tissue Engineering and Regenerative Medicine 2024;21(1):53-64
BACKGROUND:
Current polymer-based drug-eluting stents (DESs) have fundamental issues about inflammation and delayed re-endothelializaton of the vessel wall. Substance-P (SP), which plays an important role in inflammation and endothelial cells, has not yet been applied to coronary stents. Therefore, this study compares poly lactic-co-glycolic acid (PLGA)-based everolimus-eluting stents (PLGA-EESs) versus 2-methacryloyloxyethyl phosphorylcholine (MPC)-based SP-eluting stents (MPC-SPs) in in-vitro and in-vivo models.
METHODS:
The morphology of the stent surface and peptide/drug release kinetics from stents were evaluated. The invitro proliferative effect of SP released from MPC-SP is evaluated using human umbilical vein endothelial cell. Finally, the safety and efficacy of the stent are evaluated after inserting it into a pig’s coronary artery.
RESULTS:
Similar to PLGA-EES, MPC-SP had a uniform surface morphology with very thin coating layer thickness (2.074 lm). MPC-SP showed sustained drug release of SP for over 2 weeks. Endothelial cell proliferation was significantly increased in groups treated with SP (n = 3) compared with the control (n = 3) and those with everolimus (n = 3) (SP:118.9 ± 7.61% vs. everolimus: 64.3 ± 12.37% vs. the control: 100 ± 6.64%, p < 0.05). In the animal study, the percent stenosis was higher in MPC-SP group (n = 7) compared to PLGA-EES group (n = 7) (MPC-SP: 28.6 ± 10.7% vs. PLGAEES: 16.7 ± 6.3%, p < 0.05). MPC-SP group showed, however, lower inflammation (MPC-SP: 0.3 ± 0.26 vs. PLGAEES: 1.2 ± 0.48, p < 0.05) and fibrin deposition (MPC-SP: 1.0 ± 0.73 vs. PLGA-EES: 1.5 ± 0.59, p < 0.05) around the stent strut. MPC-SP showed more increased expression of cluster of differentiation 31, suggesting enhanced reendothelialization.
CONCLUSION
Compared to PLGA-EES, MPC-SP demonstrated more decreased inflammation of the vascular wall and enhanced re-endothelialization and stent coverage. Hence, MPC-SP has the potential therapeutic benefits for the treatment of coronary artery disease by solving limitations of currently available DESs.