PURPOSE: We examined the extent of anterior capsular constriction after continuous curvilinear capsulorhexis according to the initial area of opening, the postoperative period, and the material of optics of intraocular lens(IOL). PATIENTS AND METHODS: We measured the area of anterior capsular opening 1 day, 1, 2, 3, 6, and 12 months postoperatively. Sixty five eyes of 50 patients with poly "methyl methacrylate "(PMMA), foldable silicone, and foldable acrylic IOLs were included. RESULTS: There was no significant correlation between the initial area and the extent of anterior capsular constriction(r=0.090, p=0.476). There was significant reduction during the postoperative 3 months but, thereafter, the changes of the area was insignificant. The mean reduction size was larger in order of foldable silicone, PMMA, and foldable acrylic IOL. The difference between foldable silicone and acrylic IOLs was statistically significant(p=0.009). Those between foldable silicone and PMMA IOLs(p=0.580) or between PMMA and foldable acrylic IOLs(p=0.135) was not significant. CONCLUSIONS: The appropriate choice of IOL should be considered as the strategy to reduce the contraction of anterior capsular opening after continuous curvilinear capsulorhexis.
Capsulorhexis ; Constriction ; Humans ; Lenses, Intraocular* ; Polymethyl Methacrylate ; Postoperative Period ; Silicones

Dendritic cells (DCs) play a key role in activating the immune response against invading pathogens as well as dying cells or tumors. Although the immune response can be initiated by the phagocytic activity by DCs, the molecular mechanism involved in this process has not been fully investigated. Trp-Lys-Tyr-Met-Val-Met-NH2 (WKYMVM) stimulates the activation of phospholipase D (PLD) via Ca2+ increase and protein kinase C activation in mouse DC cell line, DC2.4. WKYMVM stimulates the phagocytic activity, which is inhibited in the presence of N-butanol but not t-butanol in DC2.4 cells. Furthermore, the addition of phosphatidic acid, an enzymatic product of PLD activity, enhanced the phagocytic activity in DC2.4 cells. Since at least two of formyl peptide receptor (FPR) family (FPR1 and FPR2) are expressed in DC2.4 as well as in mouse bone marrow-derived dendritic cells, this study suggests that the activation of FPR family by WKYMVM stimulates the PLD activity resulting in phagocytic activity in DC2.4 cells.
1-Butanol/pharmacology ; Animals ; Bone Marrow Cells/cytology/metabolism ; Calcium Signaling/*drug effects ; Cell Death/immunology ; Cell Line ; Communicable Diseases/immunology ; Dendritic Cells/immunology/*metabolism ; Mice ; Neoplasms/immunology ; Oligopeptides/*pharmacology ; Phagocytosis/*drug effects ; Phosphatidic Acids/pharmacology ; Phospholipase D/*metabolism ; Receptors, Formyl Peptide/*metabolism ; Research Support, Non-U.S. Gov't ; tert-Butyl Alcohol/pharmacology