Proliferative activity of a malignant tumor is known to reflect its biological aggressiveness. Proliferating cell nuclear antigen (PCNA) is a marker of cellular proliferation, and silver-stained nucleolar organizer regions (AgNORs) have been shown to correlate with ploidy and proliferative activity of cells. In transitional cell carcinoma of the renal pelvis, the prognostic value of these markers has not been well defined. We studied PCNA expression and the AgNORs count in 22 transitional cell carcinoma of the renal pelvis to assess their prognostic significance compared with their cumulative survival rate, the stage of disease and histopathologic features of the tumors. An immunohistochemical method and a standard colloidal silver staining were used. The mean percentage of PCNA positivity (PCNA index) and the mean number of AgNORs per nucleus (AgNORs score) were determined. In a multivariable analysis, PCNA indexes were significantly associated with tumor stage (p=0.024), whereas AgNORs scores were not significantly associated with the stage or histopatholgic features of the tumors. Histologic grade was correlated to disease stage at a significant level (p=0.000). But there was a trend of low tumor PCNA-indices or AgNORs counts with survival advantage for patients, but this did not reach statistical significance. The results suggest that the fraction of PCNA positive nuclei would be useful for investigating the malignant potential of renal pelvic cancers, although their clinical use as markers of biologic behavior may be limited.
Carcinoma, Transitional Cell* ; Cell Proliferation ; Colloids ; Humans ; Kidney ; Kidney Pelvis* ; Nucleolus Organizer Region ; Pelvic Neoplasms ; Ploidies ; Proliferating Cell Nuclear Antigen* ; Silver Staining ; Survival Rate

Glycogen-rich clear cell carcinoma of the breast is very rare(l -3% of breast cancer). It is defined as a tumor composed of more than 50% of optically clear, neoplastic cells, characterized by centrally located nuclei and abundant cytoplasm, being positive for periodic acid Schiff(PAS) and negative for periodic acid Schiff after diastase(D-PAS) treatment. In the absence of intraductal or in situ lobular carcinoma component, metastatic clear cell carcinomas of other organs should be considered as diagnostic possibilities. We report a case of glycogen-rich clear cell carcinoma arisen in a 62-year-old woman. The tumor revealed both solid and papillary pattern with intraductal component. The neoplastic cells had clear cytoplasm, which were PAS positive, D-PAS negative, mucicarmine negative and oil red 0 negative. More than 90% of tumor cells exhibited moderate staining for anti-estrogen receptor monoclonal antibody. Flow cytometric DNA analysis revealed diploid DNA content.
Female ; Humans ; Neoplasm Metastasis ; Breast Neoplasms

No abstract available.
Phenylketonurias*

No abstract available.
Aneurysm* ; Arteries* ; Cardiopulmonary Bypass* ; Circulatory Arrest, Deep Hypothermia Induced*

No abstract available.
Humans ; Infant* ; Leukemia, Megakaryoblastic, Acute* ; Sarcoma, Myeloid*

OBJECTIVE: The purpose of this study was to assess the validity of CAGE (cut down, annoyed, guilty feeling, eye-opener) for older adults in community METHODS: Randomly selected alcohol drinking 182 older adults over 65 years of age in Incheon-Chungu participated in this study. We assessed alcohol use disorder by Korean Composite International Diagnostic Interview (K-CIDI) and interviewed by CAGE. The CAGE questionnaire is a brief alcohol screening questionnaire that can be interviewer or self-administered. Sensitivity, specificity, positive predictive value and receiver operating characteristics (ROC) curve for CAGE scores of 1-4 for older adults over 65 years of age was calculated. RESULTS: The mean age of 182 people was 71.3 (+/-5.2) years old and the number of male and female was 142 (78.0%) and 40 (22.0%) respectively. In 239 alcohol drinking older adults, 182 (76.2%) people answered in CAGE and CIDI. Among 182 people, 58 was Alcohol Use Disorder (AUD) and 124 was non-AUD. There was no age and educational differences between 182 people (case group) and 57 people (exclusion group). The sensitivity and specificity for a cut-off score of two was 72.5% and 85.5% respectively. The calculation of area under curve (AUC) by Receiver Operating Characteristics (ROC) was 0.806. CONCLUSION: The CAGE can easily discriminate older adults with alcohol use disorder from those without such a history. We suggest a score of '2' as the optimal cut-off score of CAGE.
Adult* ; Alcohol Drinking ; Area Under Curve ; Female ; Humans ; Male ; Mass Screening ; Surveys and Questionnaires ; ROC Curve ; Sensitivity and Specificity

No abstract available.
Female ; Pregnancy ; Pregnancy, Ectopic*

OBJECTIVES:The purpose of this study is to evaluate the diagnostic validity of the three published short Geriatric Depression Scales and to identify a valid and reliable alternative to the Korean version of the Geriatric Depression Scale (GDS-K) and short form Geriatric Depression Scales (SGDS-K). METHODS:All subjects were registered elderly psychiatric patients who first visited the Geriatric Psychiatry Clinic of Seoul National University Hospital in Seoul between April 1996 and May 1999. The GDS-K, SGDS-K, Hoyl GDS-5, D'Ath GDS-4, van Marwijk GDS-4 were administered. Receiver operating characteristics (ROC) curve analysis performed to investigate the diagnostic validity of the Hoyl GDS-5, D'Ath GDS-4, and van Marwijk GDS-4. RESULTS:The best trade-off between sensitivity and specificity was achieved with a Hoyl GDS-5 score of 3 (sensitivity:0.7258, specificity:0.7717), a D'Ath GDS-4 score of 3 (sensitivity:0.5968, specificity:0.7391), and a van Marwijk GDS-4 score of 3 (sensitivity:0.6613, specificity:0.7391). The area under the ROC curves of each diagnostic tool were calculated into the Hoyl GDS-5 of 0.8198, the D'Ath GDS-4 of 0.7525, and the van Marwijk GDS-4 of 0.7528. CONCLUSION:The Hoyl GDS-5 may be utilized in screening for major depression among the elderly psychiatric patients in Korea.
Aged ; Depression ; Geriatric Psychiatry ; Humans ; Korea ; Mass Screening ; ROC Curve ; Sensitivity and Specificity ; Weights and Measures

Several tests have been used for assessing color vision but most of them are nonspecific, expensive, complicated or too time consuming to perform. We have developed a new computerized color vision test named Seohan computerized 85-hue test[SCHT/85]that has many advantages compared to Farnsworth Munsell[FM]100-hue test.SCHT/85 has 85 color caps which can be displayed based on a model of FM 100-hue test using Multimedia toolbook 4.0.Selected color caps in the lower random area can be moved and inserted to the upper result area by a mouse.At the end of the test, error scores and ring graph can be displayed in monitor and can be also printed out. Total 15 subjects performed with SCHT/85 and FM 100-hue test twice who have been showed 10 normal and 5 abnormal color vision reported with other color vision tests and the results of two tests were analysed to compare the total error scores[TES]and reproducibility. All ten normal subjects showed lower TES in SCHT/85 than FM 100-hue test and the mean TES were 31.5 and 43.6 with SCHT/85 and FM 100-hue test.The coefficients of variation [CV]were 4.3%and 22.7%with SCHT/85 and FM 100-hue test.The two tests were highly correlated[r=0.92].Five abnormal subjects showed higher TES in SCHT/85 than FM 100-hue test and the mean TES were 169.8 and 157.3 with SCHT/85 and FM 100-hue test.The coefficients of variation were 9.1%and 21.2%with SCHT/85 and FM 100-hue test.These two tests were also highly correlated[r=0.965]. In conclusion, SCHT/85 which was newly developed by authors is a highly useful test for color vision.
Color Vision* ; Multimedia ; Pilot Projects*

OBJECTIVE: It is postulated that since aripiprazole is a dopamine partial agonist and serotonin 2A receptor antagonist, aripiprazole may be effective in Tourette syndrome with few of extrapyramidal side effects. This open label study assessed the effectiveness of aripiprazole in children with Tourette syndrome (TS). METHOD: Nineteen children, aged 6 to 13 years, diagnosed with TS were participated in a 8-week open label trial. Efficacy assessments included Korean form of Yale Global Tic Severity Scale (K-YGTSS) and Clinical Global Impression scores. Safety and tolerability evaluations included extrapyramidal symptoms and effects on weight, prolactin, and corrected QT (QTc) interval. RESULTS: A significant decrease in TS symptoms, on all scales measured, appeared in 2 weeks. Adverse effects were mild and not significant. The most frequent side effects were somnolence, light headedness and headache. CONCLUSIONS: The results of current open label trial suggests the effectiveness of aripiprazole and few of side effects in the treatment of children with TS. Double-blind, placebo-, and active comparator-controlled studies are indicated to rigorously test of the efficacy of aripiprazole in TS.
Child* ; Dizziness ; Dopamine ; Headache ; Humans ; Prolactin ; Prospective Studies* ; Receptor, Serotonin, 5-HT2A ; Tics ; Tourette Syndrome* ; Treatment Outcome* ; Weights and Measures ; Aripiprazole